Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Frederic Depreux"'
Autor:
Fatih Semerci, William Tin-Shing Choi, Aleksandar Bajic, Aarohi Thakkar, Juan Manuel Encinas, Frederic Depreux, Neil Segil, Andrew K Groves, Mirjana Maletic-Savatic
Publikováno v:
eLife, Vol 6 (2017)
Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor,
Externí odkaz:
https://doaj.org/article/37cf9c79636245ebb92a61c96e350631
Autor:
Martin L Basch, Rogers M Brown II, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 5 (2016)
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate
Externí odkaz:
https://doaj.org/article/ef349eec4d0042e7ac246fa6ab85e782
Autor:
Hamilton E. Farris, Abhilash Ponnath, Michelle L. Hastings, Jennifer J Lentz, Frank Rigo, Francine M. Jodelka, Frederic Depreux
Publikováno v:
JARO: Journal of the Association for Research in Otolaryngology
The absence of functional outer hair cells is a component of several forms of hereditary hearing impairment, including Usher syndrome, the most common cause of concurrent hearing and vision loss. Antisense oligonucleotide (ASO) treatment of mice with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f9db133f8d86c95c7cef3b42199af1
https://doi.org/10.1007/s10162-017-0640-x
https://doi.org/10.1007/s10162-017-0640-x
Autor:
Frederic Depreux, Lucia A. Cherep, Francine M. Jodelka, Michelle L. Hastings, Tia N. Donaldson, Douglas G. Wallace, Kelsey T. Jennings, Adam M. McNeela
Publikováno v:
Behavioural brain research. 338
Usher syndrome, Type 1C (USH1C) is an autosomal recessive inherited disorder in which a mutation in the gene encoding harmonin is associated with multi-sensory deficits (i.e., auditory, vestibular, and visual). USH1C (Usher) mice, engineered with a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6764dcd3dc69a4d959179912af318a23
https://pubmed.ncbi.nlm.nih.gov/29037661
https://pubmed.ncbi.nlm.nih.gov/29037661
Autor:
Frederic Depreux, Andrew K. Groves, Aarohi Thakkar, William T. Choi, Aleksandar Bajić, Neil Segil, Mirjana Maletic-Savatic, Fatih Semerci, Juan Manuel Encinas
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0620c17140e36a93e2002cdb19092f01
http://europepmc.org/articles/PMC5531831
http://europepmc.org/articles/PMC5531831
Autor:
Mirjana Maletic-Savatic, Andrew K. Groves, William T. Choi, Aarohi Thakkar, Aleksandar Bajić, Neil Segil, Juan Manuel Encinas, Fatih Semerci, Frederic Depreux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b7c0449beffe02c03b4c1c1c47fc20
https://doi.org/10.7554/elife.24660.016
https://doi.org/10.7554/elife.24660.016
Autor:
Michelle L. Hastings, Frank Rigo, Sarath Vijayakumar, Timothy A. Jones, Francine M. Jodelka, Frederic Depreux, Jennifer J Lentz
Publikováno v:
Human molecular genetics. 26(18)
Usher syndrome type 1C (USH1C/harmonin) is associated with profound retinal, auditory and vestibular dysfunction. We have previously reported on an antisense oligonucleotide (ASO-29) that dramatically improves auditory function and balance behavior i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d1ef5d74758db3d31e3ff31169e062
https://pubmed.ncbi.nlm.nih.gov/28633508
https://pubmed.ncbi.nlm.nih.gov/28633508
Autor:
Fatih Semerci, Hsin-I Jen, Christine R. Norton, Hongyuan Zhang, Rogers M. Brown, Mirjana Maletic-Savatic, Thomas Gridley, Neil Segil, Renée K. Edlund, Martin L. Basch, Angelika Doetzlhofer, Susan E. Cole, Frederic Depreux, Andrew K. Groves
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91c8ae758cce5e3390d2231bdda91bf
https://doi.org/10.7554/elife.19921
https://doi.org/10.7554/elife.19921
Autor:
Hongyuan Zhang, Neil Segil, Renée K. Edlund, Fatih Semerci, Hsin-I Jen, Christine R. Norton, Frederic Depreux, Angelika Doetzlhofer, Rogers M. Brown, Susan E. Cole, Mirjana Maletic-Savatic, Thomas Gridley, Martin L. Basch, Andrew K. Groves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a915da6e44f04dd49a8deb28bda0521
https://doi.org/10.7554/elife.19921.015
https://doi.org/10.7554/elife.19921.015
Autor:
Frédéric Dépreux, Lyubov Czech, Hunter Young, Claus-Peter Richter, Yingjie Zhou, Donna S. Whitlon
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114674- (2023)
No medical interventions for noise induced hearing loss (NIHL) are approved by the Food and Drug Administration (USA). Here, we evaluate statins in CBA/CaJ mice as potential drugs for hearing loss. Direct delivery of fluvastatin to the cochlea and or
Externí odkaz:
https://doaj.org/article/fab080154d424861bc652b6245d22b75