Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Frederic Delouvroy"'
Autor:
Geneviève Vandercruyssen, Origène Nyanguile, Leen Vijgen, Frederik Pauwels, Pascale Dehertogh, Koen Dockx, Hendrik L. De Bondt, Wendy Mostmans, Benoit Devogelaere, Gregory Fanning, Vendeville Sandrine Marie Hele, Pierre Raboisson, Oliver Lenz, Frederic Delouvroy, Ann Vos, Koen Vandyck, Katrien Vermeiren, Erna Cleiren, Walter Van den Broeck, Jan Martin Berke, Kenneth Simmen, Maxwell D. Cummings
Publikováno v:
Journal of Virology. 84:2923-2934
The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7fe42c112a586f3f503effe1181796
https://doi.org/10.1128/jvi.01980-09
https://doi.org/10.1128/jvi.01980-09
Autor:
Pierre Raboisson, Tse-I Lin, Bertil Samuelsson, Frederic Delouvroy, Katrien Vermeiren, Lotta Vrang, Oliver Lenz, Kenneth Simmen, Piet Wigerinck, Michael Edlund, Annick Scholliers, Thierry Verbinnen, Herman de Kock, Åsa Rosenquist, Gregory Fanning
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1377-1385
The hepatitis C virus (HCV) NS3/4A serine protease has been explored as a target for the inhibition of viral replication in preclinical models and in HCV-infected patients. TMC435350 is a highly specific and potent inhibitor of NS3/4A protease select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47c0107cd6e60ff3a55647377fe4721
https://doi.org/10.1128/aac.01058-08
https://doi.org/10.1128/aac.01058-08
Autor:
Kenneth Simmen, Pierre Raboisson, Frederic Delouvroy, Maxwell D. Cummings, Wendy Mostmans, Tania Ivens, Pascale Dehertogh, Liesbet van der Helm, Geneviève Vandercruyssen, Origène Nyanguile, Walter Van den Broeck, Carlo Boutton, Jean Francois Bonfanti, Frederik Pauwels, Ludo Maria Marcel Quirynen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4420-4431
The exogenous control of hepatitis C virus (HCV) replication can be mediated through the inhibition of the RNA-dependent RNA polymerase (RdRp) activity of NS5B. Small-molecule inhibitors of NS5B include nucleoside and nonnucleoside analogs. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bd3cdba00a3b0ff19a49c2c9c34293
https://doi.org/10.1128/aac.00669-08
https://doi.org/10.1128/aac.00669-08
Autor:
Michael Edlund, Oliver Lenz, Pia Cecilia Kahnberg, Stefan Lindström, Frederic Delouvroy, Dominique Louis Nestor Ghislain Surleraux, Magnus Nilsson, Dmitry Antonov, Anders Eneroth, Wim Van De Vreken, Kristina Wikström, Tse-I Lin, Piet Wigerinck, Kenneth Simmen, Vladimir Ivanov, Marleen Van Dooren, Susana Ayesa, Hu Lili, Abdellah Tahri, Åsa Rosenquist, Lotta Vrang, Per-Ola Johansson, Vendeville Sandrine Marie Hele, Herman de Kock, Pierre Raboisson, Bertil Samuelsson, Björn Classon, Natalie Maria Francisca Kindermans, David McGowan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6189-6193
A novel series of P3-truncated macrocyclic HCV NS3/4A protease inhibitors containing a P2 proline-urea or carbamate scaffold was synthesized. Very potent inhibitors were obtained through the optimization of the macrocycle size, urea and proline subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ca19d51213a5c97bb70d21813a4cd8
https://doi.org/10.1016/j.bmcl.2008.10.004
https://doi.org/10.1016/j.bmcl.2008.10.004
Autor:
Frederic Delouvroy, Dominique Louis Nestor Ghislain Surleraux, Herman de Kock, Oliver Lenz, David McGowan, Pierre Raboisson, Magnus Nilsson, Åsa Rosenquist, Wim Van De Vreken, Hu Lili, Piet Wigerinck, Tse-I Lin, Bertil Samuelsson, Abdellah Tahri, Vendeville Sandrine Marie Hele, Kenneth Simmen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5095-5100
Starting from the previously reported HCV NS3/4A protease inhibitor BILN 2061, we have used a fast-follower approach to identify a novel series of HCV NS3/4A protease inhibitors in which (i) the P3 amino moiety and its capping group have been truncat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6f8a40abb2762c4fdcc63d737b45d0
https://doi.org/10.1016/j.bmcl.2008.07.124
https://doi.org/10.1016/j.bmcl.2008.07.124
Autor:
Frederic Delouvroy, Katrien Vermeiren, Dominique Louis Nestor Ghislain Surleraux, Sarvajit Chakravarty, Annick Scholliers, Pierre Raboisson, Tse-I Lin, Thierry Verbinnen, Kenneth Simmen, Oliver Lenz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1843-1849
Screening of a focused library of TGF beta kinase inhibitors in the cellular HCV replicon model with luciferase read out yielded a number of low micromolar HCV inhibitors. Medicinal chemistry driven optimization resulted in the discovery of 4-[2-(5-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eb3120dae021934f30b785bf78efee
https://doi.org/10.1016/j.bmcl.2007.01.046
https://doi.org/10.1016/j.bmcl.2007.01.046
Autor:
Lotta Vrang, Kristina Wickström, Magnus Nilsson, Pierre Raboisson, Carlo Boutton, Lourdes Salvador-Oden, Frederic Delouvroy, Natalie Roue, Bertil Samuelsson, Dominique Louis Nestor Ghislain Surleraux, Herman de Kock, David McGowan, Michael Edlund, Hu Lili, Horst Wähling, Oliver Lenz, Wim Van De Vreken, Piet Wigerinck, Abdellah Tahri, Vendeville Sandrine Marie Hele, Kenneth Simmen, Geert Pille, Elizabeth Hamelink, Åsa Rosenquist, Tse-I Lin, Vladimir Ivanov
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(17)
SAR analysis performed with a limited set of cyclopentane-containing macrocycles led to the identification of N-[17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo [13.3.0.0(4,6)]octadec-7-ene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5184fab462c9009bcdd6cee11b295151
https://pubmed.ncbi.nlm.nih.gov/18678486
https://pubmed.ncbi.nlm.nih.gov/18678486