Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Frederic D. Sigoillot"'
Autor:
Nicole M. Wong, Elizabeth Frias, Frederic D. Sigoillot, Justin H. Letendre, Marc Hild, Wilson W. Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cell-based transcriptional reporters are an invaluable part of highthroughput screening, but many such reporters have weak or transient responses. Here, the authors describe a digitizer circuit for amplifying reporter activity, increasing sensitivity
Externí odkaz:
https://doaj.org/article/9460ce096673477daa5cef61a0252db3
Autor:
Darrin D. Stuart, Mariela Jaskelioff, Jeffrey A. Engelman, Alyson K. Freeman, Daniel P. Rakiec, David A. Ruddy, Matthew D. Shirley, Felipe C. Geyer, Frederic D. Sigoillot, Tianshu Feng, Grace P. Leung
The most frequent genetic alterations in melanoma are gain-of-function (GOF) mutations in BRAF, which result in RAF–MEK–ERK signaling pathway addiction. Despite therapeutic success of RAF and MEK inhibitors in treating BRAFV600-mutant tumors, a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ff887f10d18c65cb8cab29c0716d78
https://doi.org/10.1158/1541-7786.c.6541189
https://doi.org/10.1158/1541-7786.c.6541189
Autor:
Darrin D. Stuart, Mariela Jaskelioff, Jeffrey A. Engelman, Alyson K. Freeman, Daniel P. Rakiec, David A. Ruddy, Matthew D. Shirley, Felipe C. Geyer, Frederic D. Sigoillot, Tianshu Feng, Grace P. Leung
Figure S1. Cellular phenotypes observed in response to ERK2 overexpression in A-375 cells. Figure S2. No paracrine effect was produced by cells dying due to knockdown of the essential gene PSMA3. Figure S3. A-375 xenograft tumors with ERK2 overexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51f0971ae04461a87e039b93d72942c
https://doi.org/10.1158/1541-7786.22515802.v1
https://doi.org/10.1158/1541-7786.22515802.v1
Autor:
Jingyao Li, Daniel J. Ho, Martin Henault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic D. Sigoillot, Robert J. Ihry
Publikováno v:
ACS chemical biology. 17(6)
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84df92c55bb23f5e3de70243ffd28703
https://pubmed.ncbi.nlm.nih.gov/35508359
https://pubmed.ncbi.nlm.nih.gov/35508359
Autor:
Frederic D Sigoillot, Jeremy F Huckins, Fuhai Li, Xiaobo Zhou, Stephen T C Wong, Randall W King
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25511 (2011)
Automated time-lapse microscopy can visualize proliferation of large numbers of individual cells, enabling accurate measurement of the frequency of cell division and the duration of interphase and mitosis. However, extraction of quantitative informat
Externí odkaz:
https://doaj.org/article/2c06f9aa100a4e00a6d485fbf64706f2
Publikováno v:
International Journal of Cancer; 4/20/2004, Vol. 109 Issue 4, p491-498, 8p