Zobrazeno 1 - 10
of 527
pro vyhledávání: '"Frederic D, Bushman"'
Autor:
Máire A. Conrad, Kyle Bittinger, Yue Ren, Kelly Kachelries, Jennifer Vales, Hongzhe Li, Gary D. Wu, Frederic D. Bushman, Marcella Devoto, Robert N Baldassano, Judith R. Kelsen
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTDysbiosis is associated with pediatric and adult-onset inflammatory bowel disease (IBD), but the role of dysbiosis and the microbiome in very early onset IBD (VEO-IBD) has not yet been described. Here, we aimed to demonstrate the impact of ag
Externí odkaz:
https://doaj.org/article/75bceb6e38a04628a5628960e23be4f7
Autor:
Nikhila S. Tanneti, Anant K. Patel, Li Hui Tan, Andrew D. Marques, Ranawaka A. P. M. Perera, Scott Sherrill-Mix, Brendan J. Kelly, David M. Renner, Ronald G. Collman, Kyle Rodino, Carole Lee, Frederic D. Bushman, Noam A. Cohen, Susan R. Weiss
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTThe SARS-CoV-2 pandemic was marked with emerging viral variants, some of which were designated as variants of concern (VOCs) due to selection and rapid circulation in the human population. Here, we elucidate functional features of each VOC li
Externí odkaz:
https://doaj.org/article/e12a02be8811459fa37a898b62fa7cfe
Autor:
Andrew D. Marques, Jevon Graham-Wooten, Ayannah S. Fitzgerald, Ashley Sobel Leonard, Emma J. Cook, John K. Everett, Kyle G. Rodino, Louise H. Moncla, Brendan J. Kelly, Ronald G. Collman, Frederic D. Bushman
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in immunocompromised patients provides an opportunity for viral evolution, potentially leading to the generation of new pathogenic variants. To investigate
Externí odkaz:
https://doaj.org/article/e8eba7dc67e744768c3e726f093b56ee
Autor:
Lucas Van Gorder, Bhavya S. Doshi, Elinor Willis, Timothy C. Nichols, Emma Cook, John K. Everett, Elizabeth P. Merricks, Valder R. Arruda, Frederic D. Bushman, Mary Beth Callan, Benjamin J. Samelson-Jones
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101159- (2023)
Adeno-associated viral (AAV) vectors have traditionally been viewed as predominantly nonintegrating, with limited concerns for oncogenesis. However, accumulating preclinical data have shown that AAV vectors integrate more often than previously apprec
Externí odkaz:
https://doaj.org/article/c962f9d134214b5e82348ed40acae6dc
Autor:
Filippo Dragoni, Abena K. Kwaa, Caroline C. Traut, Rebecca T. Veenhuis, Bezawit A. Woldemeskel, Angelica Camilo-Contreras, Hayley E. Raymond, Arbor G. Dykema, Eileen P. Scully, Amanda M. Rosecrans, Kellie N. Smith, Frederic D. Bushman, Francesco R. Simonetti, Joel N. Blankson
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by proliferating while avoiding immune recognition. Integration features of intact proviruses in elite controllers (ECs) and people on long-term therapy suggest that
Externí odkaz:
https://doaj.org/article/0cd68afa11b94c088efb07fe63747793
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract SARS-CoV-2 infection causes COVID-19 disease, which can result in consequences ranging from undetectable to fatal, focusing attention on the modulators of outcomes. The respiratory tract microbiome is thought to modulate the outcomes of infe
Externí odkaz:
https://doaj.org/article/6cf50a1bb07e411ea711e08992a8e4a0
Autor:
Grant Eilers, Kushol Gupta, Audrey Allen, Saira Montermoso, Hemma Murali, Robert Sharp, Young Hwang, Frederic D Bushman, Gregory Van Duyne
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011097 (2023)
HIV integrase (IN) inserts viral DNA into the host genome and is the target of the strand transfer inhibitors (STIs), a class of small molecules currently in clinical use. Another potent class of antivirals is the allosteric inhibitors of integrase,
Externí odkaz:
https://doaj.org/article/28bca840f72647ef9ea07ae7c3a99bd6
Autor:
Christopher H Gu, Layla A Khatib, Ayannah S Fitzgerald, Jevon Graham-Wooten, Caroline A Ittner, Scott Sherrill-Mix, YuChung Chuang, Laurel J Glaser, Nuala J Meyer, Frederic D Bushman, Ronald G Collman
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0289923 (2023)
BackgroundThe gut microbiome is believed to contribute to bloodstream infection (BSI) via translocation of dominant gut bacteria in vulnerable patient populations. However, conclusively linking gut and blood organisms requires stringent approaches to
Externí odkaz:
https://doaj.org/article/ae39e855920246ee9b732456a41a8b9f
Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania
Autor:
Andrew D. Marques, Scott Sherrill-Mix, John K. Everett, Hriju Adhikari, Shantan Reddy, Julie C. Ellis, Haley Zeliff, Sabrina S. Greening, Carolyn C. Cannuscio, Katherine M. Strelau, Ronald G. Collman, Brendan J. Kelly, Kyle G. Rodino, Frederic D. Bushman, Roderick B. Gagne, Eman Anis
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT The SARS-CoV-2 pandemic began by viral spillover from animals to humans; today multiple animal species are known to be susceptible to infection. White-tailed deer, Odocoileus virginianus, are infected in North America at substantial levels,
Externí odkaz:
https://doaj.org/article/5a0d2fb8079e43c4b81568ab22a969ae
Autor:
Carter Merenstein, Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor, Abigail Glascock, Kyle Bittinger, Ceylan Tanes, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Shantan Reddy, Amy E. Baxter, Josephine R. Giles, Derek A. Oldridge, Nuala J. Meyer, E. John Wherry, John E. McGinniss, Frederic D. Bushman, Ronald G. Collman
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/4210de6591cd4fcdb3d6cb3838f991b6