Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

Autor: Madhusudhan, Srinivasan, Naomi J, Petela, Johanna C, Scheinost, James, Collier, Menelaos, Voulgaris, Maurici, B Roig, Frederic, Beckouët, Bin, Hu, Kim A, Nasmyth

Publikováno v: eLife

Cohesin’s association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbfe675396bc9ea520344a1c89f85e51
https://pubmed.ncbi.nlm.nih.gov/31225797

Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I

Autor: Christophe Dez, Carlos Fernández-Tornero, Isabelle Léger-Silvestre, Marie-Kerguelen Sarthou, Michael Pilsl, Anthony K. Henras, Olga Calvo, Olivier Gadal, Marta Kwapisz, Christophe Normand, Sylvain Audibert, Titouan Genty, Adrien Chauvier, Tommy Darrière, Herbert Tschochner

Publikováno v: GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)
PLoS Genetics, Vol 15, Iss 5, p e1008157 (2019)
PLoS Genetics
PLoS Genetics, Public Library of Science, 2019, 15 (5), pp.e1008157. ⟨10.1371/journal.pgen.1008157⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
GREDOS. Repositorio Institucional de la Universidad de Salamanca

Most transcriptional activity of exponentially growing cells is carried out by the RNA Polymerase I (Pol I), which produces a ribosomal RNA (rRNA) precursor. In budding yeast, Pol I is a multimeric enzyme with 14 subunits. Among them, Rpa49 forms wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c564b76503aadd7249daff34c1b9d296
http://hdl.handle.net/10261/179881