Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Frederic Bard"'
Autor:
Jeremy C Yeo, Felicia P Tay, Rebecca Bennion, Omar Loss, Jacquie Maignel, Laurent Pons, Keith Foster, Matthew Beard, Frederic Bard
Publikováno v:
eLife, Vol 12 (2024)
Botulinum neurotoxin A (BoNT/A) is a highly potent proteolytic toxin specific for neurons with numerous clinical and cosmetic uses. After uptake at the synapse, the protein is proposed to translocate from synaptic vesicles to the cytosol through a se
Externí odkaz:
https://doaj.org/article/fe90455008ae4419983b2985a8d0c38a
Autor:
Mona Nazemi, Bian Yanes, Montserrat Llanses Martinez, Heather J Walker, Khoa Pham, Mark O Collins, Frederic Bard, Elena Rainero
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002406 (2024)
Breast tumours are embedded in a collagen I-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumour growth. Metabolic adaptation is required for cancer cells to endure these conditions. Here,
Externí odkaz:
https://doaj.org/article/73bd8338597b4be8864562ecae43c95e
Autor:
Yew Chung Tang, Szu-Chi Ho, Elisabeth Tan, Alvin Wei Tian Ng, John R. McPherson, Germaine Yen Lin Goh, Bin Tean Teh, Frederic Bard, Steven G. Rozen
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-16 (2018)
Abstract Background Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or synthetic-lethal (PTEN-SSL) genes a
Externí odkaz:
https://doaj.org/article/d5206bb396b84eb29668b60694b3e136
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214118 (2019)
The enzymes GALNTs add GalNAc sugar to Ser and Thr residues, forming the Tn glycan. GALNTs are activated by trafficking from Golgi to ER, a process driven by the Src kinase and negatively regulated by ERK8. This GALNTs activation (aka GALA) pathway i
Externí odkaz:
https://doaj.org/article/ec053ce163434cfc866fb2f9c383b961
Autor:
Kan Xing Wu, Patchara Phuektes, Pankaj Kumar, Germaine Yen Lin Goh, Dimitri Moreau, Vincent Tak Kwong Chow, Frederic Bard, Justin Jang Hann Chu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Enterovirus 71 (EV71) infection causes a spectrum of symptoms including neurological disease. To improve our understanding of EV71-host interactions, Wu et al. here perform a genome-wide RNAi screen, which implicates cell cycle regulation and ER-asso
Externí odkaz:
https://doaj.org/article/b570f2103dc44d409e3bad0d44e49be7
Autor:
David E Gordon, Joanne Chia, Kamburpola Jayawardena, Robin Antrobus, Frederic Bard, Andrew A Peden
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006698 (2017)
The cellular machinery required for the fusion of constitutive secretory vesicles with the plasma membrane in metazoans remains poorly defined. To address this problem we have developed a powerful, quantitative assay for measuring secretion and used
Externí odkaz:
https://doaj.org/article/92d90e1a7dd54c66888c6701d7f5eb15
Autor:
Frederic Bard, Joanne Chia
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180005 (2017)
Externí odkaz:
https://doaj.org/article/a7d3a2f391d24690bf5e3f189354492a
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-20 (2012)
Abstract The Golgi apparatus has many important physiological functions, including sorting of secretory cargo and biosynthesis of complex glycans. These functions depend on the intricate and compartmentalized organization of the Golgi apparatus. To i
Externí odkaz:
https://doaj.org/article/bdf1f810015a467094c48832992670a6
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138789 (2015)
The Golgi apparatus plays a pivotal role in the sorting and post-translational modifications of secreted and membrane proteins. In mammalian cells, the Golgi is organized in stacks of cisternae linked together to form a network with a ribbon shape. R
Externí odkaz:
https://doaj.org/article/07e5aac796024bcea29470a63248b2f5
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
Externí odkaz:
https://doaj.org/article/dd480491a7684d97acbca42c582e5bfd