Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Frederic B. Thalheimer"'
Autor:
Laura Kapitza, Naphang Ho, Thomas Kerzel, Annika M. Frank, Frederic B. Thalheimer, Arezoo Jamali, Thomas Schaser, Christian J. Buchholz, Jessica Hartmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Chimeric antigen receptor (CAR)-expressing T cells are a complex and heterogeneous gene therapy product with variable phenotype compositions. A higher proportion of less differentiated CAR T cells is usually associated with improved antitumoral funct
Externí odkaz:
https://doaj.org/article/d16778f7ed9243059db65c4e58de6741
Autor:
Naphang Ho, Shiwani Agarwal, Michela Milani, Alessio Cantore, Christian J. Buchholz, Frederic B. Thalheimer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 144-156 (2022)
Pre-clinical humanized mouse models are a powerful tool to evaluate immunotherapies. NSG-SGM3 mice reconstituted with human stem cells (huSGM3) develop pronounced human myeloid cells due to transgenic expression of stem cell factor, granulocyte-macro
Externí odkaz:
https://doaj.org/article/e78a0da4c10e4bfabac0ead54b2a2f99
Autor:
Filippos T. Charitidis, Elham Adabi, Frederic B. Thalheimer, Colin Clarke, Christian J. Buchholz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 359-369 (2021)
Quantifying gene expression in individual cells can substantially improve our understanding about complex genetically engineered cell products such as chimeric antigen receptor (CAR) T cells. Here we designed a single-cell RNA sequencing (scRNA-seq)
Externí odkaz:
https://doaj.org/article/1ddaed49aea24261abd1f8f44017b01a
Autor:
Filippos T. Charitidis, Elham Adabi, Frederic B. Thalheimer, Colin Clarke, Christian J. Buchholz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 207-209 (2022)
Externí odkaz:
https://doaj.org/article/595471b9f54c423581688e346b7d7a3a
Autor:
Arezoo Jamali, Jamshid Hadjati, Zahra Madjd, Hamid Reza Mirzaei, Frederic B. Thalheimer, Shiwani Agarwal, Halvard Bonig, Evelyn Ullrich, Jessica Hartmann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Natural killer (NK) cells are a noteworthy lymphocyte subset in cancer adoptive cell therapy. NK cells initiate innate immune responses against infections and malignancies with natural cytotoxicity, which is independent of foreign antigen recognition
Externí odkaz:
https://doaj.org/article/f66f202bf8af479cb72f581f3d8fcb1a
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
Chimeric antigen receptor (CAR) T cells are in prime focus of current research in cancer immunotherapy. Facilitating CAR T cell generation is among the top goals. We have recently demonstrated direct in vivo generation of human CD19-CAR T cells by ta
Externí odkaz:
https://doaj.org/article/a54ffa6b658d4c4997a6875352cc2e76
Autor:
Johanna Reul, Janina Frisch, Christine E. Engeland, Frederic B. Thalheimer, Jessica Hartmann, Guy Ungerechts, Christian J. Buchholz
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Immune checkpoint inhibitors (ICIs) can block distinct receptors on T cells or tumor cells thus preventing T cell inactivation and tumor immune escape. While the clinical response to treatment with ICIs in cancer patients is impressive, this therapy
Externí odkaz:
https://doaj.org/article/c9b2651adab048cc8ecea4b5e41846c3
Autor:
Uta Rabenhorst, Frederic B. Thalheimer, Katharina Gerlach, Marek Kijonka, Stefanie Böhm, Daniela S. Krause, Franz Vauti, Hans-Henning Arnold, Timm Schroeder, Frank Schnütgen, Harald von Melchner, Michael A. Rieger, Martin Zörnig
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1847-1855 (2015)
The ability of hematopoietic stem cells (HSCs) to self-renew is a prerequisite for the establishment of definitive hematopoiesis and life-long blood regeneration. Here, we report the single-stranded DNA-binding transcriptional regulator far upstream
Externí odkaz:
https://doaj.org/article/c1163f6eebe147a3bd1e930b1679b3f9
Cytokine-Regulated GADD45G Induces Differentiation and Lineage Selection in Hematopoietic Stem Cells
Autor:
Frederic B. Thalheimer, Susanne Wingert, Pangrazio De Giacomo, Nadine Haetscher, Maike Rehage, Boris Brill, Fabian J. Theis, Lothar Hennighausen, Timm Schroeder, Michael A. Rieger
Publikováno v:
Stem Cell Reports, Vol 3, Iss 1, Pp 34-43 (2014)
The balance of self-renewal and differentiation in long-term repopulating hematopoietic stem cells (LT-HSC) must be strictly controlled to maintain blood homeostasis and to prevent leukemogenesis. Hematopoietic cytokines can induce differentiation in
Externí odkaz:
https://doaj.org/article/18b566a963ac46ad93e8085acba22083
Autor:
Arezoo Jamali, Naphang Ho, Angela Braun, Elham Adabi, Frederic B Thalheimer, Christian J Buchholz
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 784-804 (2024)
Abstract Cytokine release syndrome (CRS) is a significant side-effect of conventional chimeric antigen receptor (CAR) T-cell therapy. To facilitate patient accessibility, short-term (st) CAR T cells, which are administered to patients only 24 h after
Externí odkaz:
https://doaj.org/article/3e9529b73a504bd2bc8f86fd1a55c755