Výsledky vyhledávání - "Frede W. Jacobsen"

Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis

Autor: Lars Slørdal, Frede W. Jacobsen, Erlend B. Smeland, O. P. Veiby, David V. Goeddel, Mike Rothe, Leiv S. Rusten, Sten Eirik W. Jacobsen

Publikováno v: Proceedings of the National Academy of Sciences. 91:10695-10699

Biological effects of tumor necrosis factor alpha (TNF-alpha) are mediated through two cell surface receptors, the 55-kDa TNF receptor and the 75-kDa TNF receptor. The present study investigated the relative roles of the two TNF receptors in normal h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733844c436b29fab9138d0df6a78839e
https://doi.org/10.1073/pnas.91.22.10695

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Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors

Autor: Ian McNiece, Cecilia Fahlman, Sten Eirik W. Jacobsen, O. P. Veiby, Heidi Kiil Blomhoff, Frede W. Jacobsen

Publikováno v: Blood. 84:1528-1533

Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac48f32d7199c00ede52b25a32dfdc01
https://doi.org/10.1182/blood.v84.5.1528.1528

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Direct synergistic effects of interleukin-7 on in vitro myelopoiesis of human CD34+ bone marrow progenitors

Autor: Sten Eirik W. Jacobsen, Frede W. Jacobsen, Leiv S. Rusten

Publikováno v: Blood. 84:775-779

Interleukin-7 (IL-7) is an important growth factor in B and T lymphopoiesis in mouse and human, whereas IL-7 has been regarded to lack proliferative effects on cells within the myeloid lineage. However, we have recently reported that IL-7 potently ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41e370a2d4fc94f6289382023342b8ab
https://doi.org/10.1182/blood.v84.3.775.775

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Tumor necrosis factor-alpha inhibits stem cell factor-induced proliferation of human bone marrow progenitor cells in vitro. Role of p55 and p75 tumor necrosis factor receptors

Autor: E. Lien, Leiv S. Rusten, Frede W. Jacobsen, Erlend B. Smeland, Werner Lesslauer, Claire M. Dubois, Hansruedi Loetscher, Sten Eirik W. Jacobsen

Publikováno v: Journal of Clinical Investigation. 94:165-172

Stem cell factor (SCF), a key regulator of hematopoiesis, potently synergizes with a number of hematopoietic growth factors. However, little is known about growth factors capable of inhibiting the actions of SCF. TNF-alpha has been shown to act as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6feb5870d047d9d3f34bf7ded51e4ab6
https://doi.org/10.1172/jci117303

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Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors

Autor: Hansruedi Loetscher, Werner Lesslauer, Sten Eirik W. Jacobsen, Erlend B. Smeland, Frede W. Jacobsen, Leiv S. Rusten

Publikováno v: Blood. 83:3152-3159

Tumor necrosis factor alpha (TNF alpha) has previously been reported to have both inhibitory and stimulatory effects on hematopoietic progenitor cells. Specifically, TNF alpha has been proposed to stimulate early hematopoiesis in humans. In the prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dcb28c1acf5b18becfc3e5cd57401cc
https://doi.org/10.1182/blood.v83.11.3152.3152

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Novel role of interleukin 7 in myelopoiesis: stimulation of primitive murine hematopoietic progenitor cells

Autor: Frede W. Jacobsen, C. Skjønsberg, O. P. Veiby, Sten Eirik W. Jacobsen

Publikováno v: The Journal of Experimental Medicine

Interleukin 7 (IL-7) has been demonstrated to be an important regulator of the growth of B and T cell precursors as well as mature T cells, whereas IL-7 has been reported to have no direct myeloproliferative effects. Here we show that IL-7 potently a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95daa61d0429d4becbd60af1d75ea837
https://doi.org/10.1084/jem.178.5.1777

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8-bromo-cAMP and 8-CPT-cAMP increase the density of beta-adrenoceptors in hepatocytes by a mechanism not mimicking the effect of cAMP

Autor: Magne Refsnes, Dagny Sandnes, Thoralf Christoffersen, Frede W. Jacobsen

Publikováno v: Pharmacologytoxicology. 79(1)

Addition of 8-bromo-adenosine 3',5'-cyclic monophosphate (8-bromo-cAMP) or 8-(4-chlorophenylthio)-adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP) to hepatocytes at the time of plating enhanced the acquisition of beta-adrenoceptors that occurs spont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0560ccd986201b1f0f233449cc7b2
https://pubmed.ncbi.nlm.nih.gov/8841091

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Long-term inhibitory effect of cAMP on beta-adrenoceptor acquisition and nonselective attenuation of adenylyl cyclase in hepatocytes

Autor: Frede W. Jacobsen, Magne Refsnes, Thoralf Christoffersen, Dagny Sandnes

Publikováno v: European journal of pharmacology. 246(2)

Long-term effects of cAMP on the surface expression of beta-adrenoceptors and adenylyl cyclase activity were investigated in primary cultures of rat hepatocytes. beta-Adrenoceptor density and catecholamine-responsive adenylyl cyclase activity increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cd72f3d7fd7c52d18e4a87e0fbf877
https://pubmed.ncbi.nlm.nih.gov/8397096

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Modes of Determining β-Adrenoceptor Number in Human Mononuclear Leucocytes

Autor: S. Jacobsen, Dagny Sandnes, Frede W. Jacobsen

Publikováno v: Pharmacology & Toxicology. 61:265-270

Inhibition of total 125I-ICYP binding to intact human mononuclear leucocytes at 32 degrees by propranolol and (+/-) CGP-12177 was biphasic. The high affinity component of 125I-ICYP binding, representing approximately 30% of total, was stereospecific,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aa90aaa17972a1cfbbd95bf48cd14b
https://doi.org/10.1111/j.1600-0773.1987.tb01816.x

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