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In contrast with the extensively characterized effects of transforming growth factor-beta (TGF-beta) on proliferation and differentiation of hematopoietic progenitors, little is known about the effects of TGF-beta on viability of normal hematopoietic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60ca35a47485f897db87d3563506705a
https://doi.org/10.1182/blood.v86.8.2957.2957

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Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis

Autor: Lars Slørdal, Frede W. Jacobsen, Erlend B. Smeland, O. P. Veiby, David V. Goeddel, Mike Rothe, Leiv S. Rusten, Sten Eirik W. Jacobsen

Publikováno v: Proceedings of the National Academy of Sciences. 91:10695-10699

Biological effects of tumor necrosis factor alpha (TNF-alpha) are mediated through two cell surface receptors, the 55-kDa TNF receptor and the 75-kDa TNF receptor. The present study investigated the relative roles of the two TNF receptors in normal h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733844c436b29fab9138d0df6a78839e
https://doi.org/10.1073/pnas.91.22.10695

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Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors

Autor: Ian McNiece, Cecilia Fahlman, Sten Eirik W. Jacobsen, O. P. Veiby, Heidi Kiil Blomhoff, Frede W. Jacobsen

Publikováno v: Blood. 84:1528-1533

Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac48f32d7199c00ede52b25a32dfdc01
https://doi.org/10.1182/blood.v84.5.1528.1528

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Direct synergistic effects of interleukin-7 on in vitro myelopoiesis of human CD34+ bone marrow progenitors

Autor: Sten Eirik W. Jacobsen, Frede W. Jacobsen, Leiv S. Rusten

Publikováno v: Blood. 84:775-779

Interleukin-7 (IL-7) is an important growth factor in B and T lymphopoiesis in mouse and human, whereas IL-7 has been regarded to lack proliferative effects on cells within the myeloid lineage. However, we have recently reported that IL-7 potently ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41e370a2d4fc94f6289382023342b8ab
https://doi.org/10.1182/blood.v84.3.775.775

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Tumor necrosis factor-alpha inhibits stem cell factor-induced proliferation of human bone marrow progenitor cells in vitro. Role of p55 and p75 tumor necrosis factor receptors

Autor: E. Lien, Leiv S. Rusten, Frede W. Jacobsen, Erlend B. Smeland, Werner Lesslauer, Claire M. Dubois, Hansruedi Loetscher, Sten Eirik W. Jacobsen

Publikováno v: Journal of Clinical Investigation. 94:165-172

Stem cell factor (SCF), a key regulator of hematopoiesis, potently synergizes with a number of hematopoietic growth factors. However, little is known about growth factors capable of inhibiting the actions of SCF. TNF-alpha has been shown to act as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6feb5870d047d9d3f34bf7ded51e4ab6
https://doi.org/10.1172/jci117303

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