Výsledky vyhledávání - "Freddy van Goethem"

Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy

Autor: Ilse Van den Wyngaert, Willem Talloen, Bie Verbist, Steffen Jaensch, Freddy Van Goethem, Geert R. Verheyen, Marjolein Crabbe, Liesbet Vervoort, Steven Osselaer, D. Beerens, Hinrich W. H. Göhlmann, Cindy Bosmans, Geert Van Hecke, Dirk Wuyts

Publikováno v: Chemical Research in Toxicology. 28:1914-1925

During drug discovery and development, the early identification of adverse effects is expected to reduce costly late-stage failures of candidate drugs. As risk/safety assessment takes place rather late during the development process and due to the li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73edfa52b246d16f884a9ba1022a8c1c
https://doi.org/10.1021/acs.chemrestox.5b00103

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Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

Autor: Erik Hansen, Freddy Van Goethem, Natalie Mesens, Peter de Witte, Camila V. Esguerra, Jacky Van Gompel, Rik Nuyts, Alexander D. Crawford, Pham Duc Hung, Andre Wolterbeek, Aswin Menke

Publikováno v: Journal of Applied Toxicology. 35:1017-1029

Drug-induced liver injury (DILI) is poorly predicted by single-cell-based assays, probably because of the lack of physiological interactions with other cells within the liver. An intact whole liver system such as one present in zebrafish larvae could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2dad8b5133a0708172f7e3f79ee8694
https://doi.org/10.1002/jat.3091

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Analysis of negative historical control group data from the in vitro micronucleus assay using TK6 cells

Autor: Sawako Kasamoto, Maik Schuler, James Whitwell, Véronique Thybaud, Ozaki Masayasu, Jennifer Y. Tanir, Freddy Van Goethem, Robert Smith, Francesco Marchetti, Martha M. Moore, Joan Christiansen, Leon F. Stankowski, Yan Li, Jin Tanaka, Mick D. Fellows, Kiyohiro Hashimoto, Azeddine Elhajouji, David P. Lovell

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis. 825

The recent revisions of the Organisation for Economic Co-operation and Development (OECD) genetic toxicology test guidelines emphasize the importance of historical negative controls both for data quality and interpretation. The goal of a HESI Genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bc5009039d3bda60624b9a79f82d52
https://pubmed.ncbi.nlm.nih.gov/29307374

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Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: Protocol optimization and transferability assessment

Autor: Marlies De Boeck, Svetlana L. Avlasevich, Azeddine Elhajouji, Freddy Van Goethem, Matthew Tate, Kris Van Dijck, Jeffrey C. Bemis, Frédéric Saad, Richard M. Walmsley, Steven M. Bryce, Magdalena Lukamowicz-Rajska, Stephen D. Dertinger

Publikováno v: Environmental and Molecular Mutagenesis. 54:180-194

An automated approach for scoring in vitro micronuclei (MN) has been described in which flow cytometric analysis is combined with compound exposure, processing, and sampling in a single 96-well plate (Bryce SM et al. [2010]: Mutat Res 703:191-199). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48ec5d06666b8cdfafff1e3a512142e7
https://doi.org/10.1002/em.21760

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Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future

Autor: Svetlana L. Avlasevich, Stephen D. Dertinger, Anthony M. Lynch, Azeddine Elhajouji, Steven M. Bryce, Marlies De Boeck, John Nicolette, Freddy Van Goethem, Jing Shi

Publikováno v: Mutagenesis. 26:147-152

The relative simplicity of the in vitro micronucleus (MNvit) endpoint has made it amenable to several automated scoring approaches. Flow cytometry is one such scoring platform that has been successfully employed. This review describes the origins of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd7275f820fe75ac97ea3a9d3c7de9
https://doi.org/10.1093/mutage/geq058

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Follow-up actions from positive results of in vitro genetic toxicity testing

Publikováno v: Environmental and Molecular Mutagenesis. 52:177-204

Appropriate follow-up actions and decisions are needed when evaluating and interpreting clear positive results obtained in the in vitro assays used in the initial genotoxicity screening battery (i.e., the battery of tests generally required by regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63ae4d2b7d7d4a81d32d1609a101535
https://doi.org/10.1002/em.20617

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Development of a new opacitometer for the bovine corneal opacity and permeability (BCOP) assay

Autor: Ann De Smedt, Philippe Vanparys, Erik Hansen, Jacky Van Gompel, Marc Sysmans, Freddy Van Goethem

Publikováno v: Toxicology in Vitro. 24:1854-1861

The bovine corneal opacity and permeability (BCOP) assay is an in vitro eye irritation test that relies on the measurement of induced opacity and permeability evaluated in isolated bovine corneas. Routinely, opacity is measured by an OP-KIT opacitome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbac360801ade165a6a588302f559b6
https://doi.org/10.1016/j.tiv.2010.04.012

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Screening for phospholipidosis induced by central nervous drugs: Comparing the predictivity of an in vitro assay to high throughput in silico assays

Autor: Erik Hansen, Geert R. Verheyen, Freddy Van Goethem, Jaques Van Gompel, Margino Steemans, Natalie Mesens

Publikováno v: Toxicology in Vitro. 24:1417-1425

Drug-induced phospholipidosis is a side effect for which drug candidates can be screened in the drug discovery phase. The numerous in silico models that have been developed as a first line of screening are based on the characteristic physicochemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b0a9774fb703277dd40cc489fd5a5a
https://doi.org/10.1016/j.tiv.2010.04.007

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