Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Freddy Zhang"'
Autor:
Freddy Zhang, Benjamin Rein, Ping Zhong, Treefa Shwani, Megan Conrow-Graham, Zi-Jun Wang, Zhen Yan
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Autism spectrum disorder (ASD) is a lifelong developmental disorder characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications and chromatin remodeling, have been
Externí odkaz:
https://doaj.org/article/374688eb5f174c60957cfb58562ca848
Publikováno v:
International Journal of Neuropsychopharmacology. 25:877-889
Background Microdeletion of the human 16p11.2 gene locus confers risk for autism spectrum disorders and intellectual disability. How 16p11.2 deletion is linked to these neurodevelopmental disorders and whether there are treatment avenues for the mani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5fdb0e242dc2cdb69c7a2877d469ac
https://doi.org/10.1093/ijnp/pyac048
https://doi.org/10.1093/ijnp/pyac048
Autor:
Ben Rein, Ping Zhong, Freddy Zhang, Kaijie Ma, Fengwei Yang, Zi-Jun Wang, Qing Cao, Jamal B Williams, Zhen Yan
Publikováno v:
Neuropsychopharmacology
Large-scale genetic screening has identified KMT5B (SUV420H1), which encodes a histone H4 K20 di- and tri-methyltransferase highly expressed in prefrontal cortex (PFC), as a top-ranking high-risk gene for autism. However, the biological function of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedb9e2f35655bd2d9c6c318be1e0683
https://doi.org/10.1038/s41386-021-01029-y
https://doi.org/10.1038/s41386-021-01029-y
Autor:
Benjamin Rein, Zi-Jun Wang, Ping Zhong, Zhen Yan, Freddy Zhang, Megan Conrow-Graham, Treefa Shwani
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Autism spectrum disorder (ASD) is a lifelong developmental disorder characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications and chromatin remodeling, have been implicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282e75424a9c4e31a38a70ee190a614a
https://doaj.org/article/374688eb5f174c60957cfb58562ca848
https://doaj.org/article/374688eb5f174c60957cfb58562ca848
Autor:
Zi-Jun Wang, Treefa Shwani, Junting Liu, Ping Zhong, Fengwei Yang, Kelcie Schatz, Freddy Zhang, Arnd Pralle, Zhen Yan
Publikováno v:
Mol Psychiatry
Chronic social isolation stress during adolescence induces susceptibility for neuropsychiatric disorders. Here we show that 5-week post-weaning isolation stress induces sex-specific behavioral abnormalities and neuronal activity changes in the prefro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36e369a049374dc31924a81b3941aa9
https://pubmed.ncbi.nlm.nih.gov/35449296
https://pubmed.ncbi.nlm.nih.gov/35449296
Autor:
Freddy Zhang, Kaijie Ma, Wei Wang, Zhen Yan, Emmanuel Matas, Jing Wei, Qing Cao, Jia Cheng, Yan Zheng, Lin Lin, Guojun Chen, Aiyi Liu, Zi-Jun Wang, Xiaomin Wang
Publikováno v:
Brain. 142:787-807
Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is suggested as one of the key pathophysiological bases of ageing and neurodegeneration. Here we found that, in the late-stage familial Alzheimer's disease (FAD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9507aa33f741f9e4a398957d02f2ebc
https://doi.org/10.1093/brain/awy354
https://doi.org/10.1093/brain/awy354
Publikováno v:
International Journal of Bank Marketing. 36:849-867
Purpose The purpose of this paper is to test the influence of managerial coaching on frontline employee customer orientation, sales orientation and performance in a Chinese context. Further to this first goal, the authors also aim to compare these re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870c4fb92a60f335da91baca74a0ab43
https://doi.org/10.1108/ijbm-04-2017-0078
https://doi.org/10.1108/ijbm-04-2017-0078
Publikováno v:
The Journal of Neuroscience. 38:5939-5948
Microdeletion of the human 16p11.2 gene locus has been linked to autism spectrum disorder (ASD) and intellectual disability and confers risk for a number of other neurodevelopmental deficits. Transgenic mice carrying 16p11.2 deletion (16p11+/-) displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341d10d7910343d99c7f8949397e9190
https://doi.org/10.1523/jneurosci.0149-18.2018
https://doi.org/10.1523/jneurosci.0149-18.2018
Autor:
Alea A. Mills, Benjamin Rein, Freddy Zhang, Zhen Yan, Tao Tan, Jamal B Williams, Wei Wang, Fengwei Yang
Publikováno v:
Molecular psychiatry
The human 16p11.2 gene locus is a hot-spot for copy number variations which predispose carriers to a range of neuropsychiatric phenotypes. Microduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability (ID) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dfcd4d8c278b8c2be792ed7cbd3613
https://pubmed.ncbi.nlm.nih.gov/32099100
https://pubmed.ncbi.nlm.nih.gov/32099100
Autor:
Fengwei Yang, Jie Wang, Kaijie Ma, Zihua Hu, Emmanuel Matas, Freddy Zhang, Zhen Yan, Tao Liu, Ping Zhong, Lin Lin, Paul Greengard, Seo Js, Zi-Jun Wang
Publikováno v:
Mol Psychiatry
Many of the genes disrupted in autism are identified as histone-modifying enzymes and chromatin remodelers, most prominently those that mediate histone methylation/demethylation. However, the role of histone methylation enzymes in the pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd5ade3897052cf23e808f9132184e8
https://pubmed.ncbi.nlm.nih.gov/31520066
https://pubmed.ncbi.nlm.nih.gov/31520066