Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Freda K Stevenson"'
Autor:
Jantipa Jobsri, Alex Allen, Deepa Rajagopal, Michael Shipton, Kostya Kanyuka, George P Lomonossoff, Christian Ottensmeier, Sandra S Diebold, Freda K Stevenson, Natalia Savelyeva
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118096 (2015)
Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic
Externí odkaz:
https://doaj.org/article/47ed0c9573c541e4ad1d874e2b4b03b2
Autor:
Eleonora Li Causi, Suraj C Parikh, Lindsey Chudley, David M Layfield, Christian H Ottensmeier, Freda K Stevenson, Gianfranco Di Genova
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136717 (2015)
CD4+ T helper memory (Thmem) cells influence both natural and vaccine-boosted immunity, but mechanisms for their maintenance remain unclear. Pro-survival signals from the common gamma-chain cytokines, in particular IL-7, appear important. Previously
Externí odkaz:
https://doaj.org/article/85f5e9ebbe6b498eaf2416e51749a086
Autor:
Andrew J. Steele, Jan A. Burger, Greg P. Coffey, Francesco Forconi, Graham Packham, Freda K. Stevenson, Jonathan C. Strefford, Anjali Pandey, Pamela B. Conley, Peter W.M. Johnson, Andrew Davies, Lindsay D. Smith, Jack Parnell, Alice Hayman, Sarah Wilmore, Marta Larrayoz, Rachel C. Dobson, Stefan Koehrer, Matthew D. Blunt
Supplementary methods and Figures Supplementary Figure 1. Effect of cerdulatinib on Immobilised anti-IgM mediated signaling Supplementary Figure 2. Effect of cerdulatinib on soluble anti-IgM mediated signaling Supplementary Figure 3. Effect of cerdul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a468e825532cc2770eba48a39c5394f7
https://doi.org/10.1158/1078-0432.22463541
https://doi.org/10.1158/1078-0432.22463541
Autor:
Francesco Forconi, Freda K. Stevenson, Graham Packham, Andrew J. Steele, Livio Trentin, Peter W. Johnson, Ian Tracy, Annalisa D'Avola, Giorgia Chiodin, Samantha Drennan
Purpose:In chronic lymphocytic leukemia (CLL), disease progression associates with surface IgM (sIgM) levels and signaling capacity. These are variably downmodulated in vivo and recover in vitro, suggesting a reversible influence of tissue-located an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d48044b2377dccbafbdf0dcea6600a8
https://doi.org/10.1158/1078-0432.c.6528189
https://doi.org/10.1158/1078-0432.c.6528189
Autor:
Andrew J. Steele, Jan A. Burger, Greg P. Coffey, Francesco Forconi, Graham Packham, Freda K. Stevenson, Jonathan C. Strefford, Anjali Pandey, Pamela B. Conley, Peter W.M. Johnson, Andrew Davies, Lindsay D. Smith, Jack Parnell, Alice Hayman, Sarah Wilmore, Marta Larrayoz, Rachel C. Dobson, Stefan Koehrer, Matthew D. Blunt
Purpose: B-cell receptor (BCR)–associated kinase inhibitors, such as ibrutinib, have revolutionized the treatment of chronic lymphocytic leukemia (CLL). However, these agents are not curative, and resistance is already emerging in a proportion of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65982893f3a24771c803dc31b3ed3e60
https://doi.org/10.1158/1078-0432.c.6525432
https://doi.org/10.1158/1078-0432.c.6525432
Autor:
Graham Packham, Pavel Klener, Lloyd Mackenzie, Jennifer Cross, Andrew J. Steele, Francesco Forconi, Mark Cragg, Freda K. Stevenson, Curtis Harwig, Jeremy Pettigrew, Georg Lenz, Chris T. Williamson, Laura Karydis, Nicola J. Weston-Bell, Karel Helman, Michael Svaton, Jana Karolova, Matthew J. Carter, Yohannes Gebreselassie, Johanna Richter, Lindsay D. Smith, Beatriz Valle-Argos, Elizabeth A. Lemm
Supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067d77f6406b11ba2ff53f0855ef08b2
https://doi.org/10.1158/1078-0432.22478181
https://doi.org/10.1158/1078-0432.22478181
Autor:
Francesco Forconi, Freda K. Stevenson, Graham Packham, Andrew J. Steele, Livio Trentin, Peter W. Johnson, Ian Tracy, Annalisa D'Avola, Giorgia Chiodin, Samantha Drennan
Supplementary Tables S1-S2 and Figures S1-S4 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37476898a6b2f9de79ed9274e267d98d
https://doi.org/10.1158/1078-0432.22472301
https://doi.org/10.1158/1078-0432.22472301
Autor:
Christian H. Ottensmeier, Freda K. Stevenson, Gareth J. Thomas, Ugur Sahin, Petra Simon, Toni Weinschenk, Duncan I. Jodrell, Alan Anthoney, Sally Clive, Ann O'Callaghan, Andrew Bateman, Sarah Halford, Ceri Edwards, Emily Buxton, Paul Lloyd-Evans, Andrew King, Stephen M. Thirdborough, Jana Stasakova, Lindsey Chudley, Angelica Cazaly, Ann Mander, Katy J. McCann
Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus toxin.Experimental Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4202489da8884143afe28a39cda33e82
https://doi.org/10.1158/1078-0432.c.6524756.v1
https://doi.org/10.1158/1078-0432.c.6524756.v1
Autor:
Andrew J. Steele, Freda K. Stevenson, Joe Taylor, Mark J. Coldwell, Graham Packham, Sarah Wilmore, Elizabeth Lemm, Alison Yeomans, Francesco Forconi, Rachel Fell, Karly-Rai Rogers-Broadway
Publikováno v:
Cellular and Molecular Life Sciences
Signaling via the B-cell receptor (BCR) is a key driver and therapeutic target in chronic lymphocytic leukemia (CLL). BCR stimulation of CLL cells induces expression of eIF4A, an initiation factor important for translation of multiple oncoproteins, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bb8b1f4d8bff40a8702adbd37299e5
https://doi.org/10.1007/s00018-021-03910-x
https://doi.org/10.1007/s00018-021-03910-x
Publikováno v:
Blood
In chronic lymphocytic leukemia (CLL), increasing knowledge of the biology of the tumor cells has led to transformative improvements in our capacity to assess and treat patients. The dependence of tumor cells on surface immunoglobulin receptor signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15223150547c3c5820ec7d5a0b280cf0
https://doi.org/10.1182/blood.2020010029
https://doi.org/10.1182/blood.2020010029