Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Freda K Stevenson"'
Autor:
Annabel R. Minton, Lindsay D. Smith, Dean J. Bryant, Jonathan C. Strefford, Francesco Forconi, Freda K. Stevenson, Edd James, Geir Åge Løset, Ludvig A. Munthe, Andrew J. Steele, Graham Packham
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 1, Pp 37-49 (2022)
Aim: T-helper cells could play an important role in the pathogenesis of chronic lymphocytic leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble antigens targeted from the B-cell receptor to T-helper cells via major histo
Externí odkaz:
https://doaj.org/article/ac5ae262efeb47cfa557944906cc5bb4
Autor:
Beatriz Valle-Argos, Giorgia Chiodin, Dean J. Bryant, Joe Taylor, Elizabeth Lemm, Patrick J. Duriez, Philip J. Rock, Jonathan C. Strefford, Francesco Forconi, Richard W. Burack, Graham Packham, Freda K. Stevenson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In follicular lymphoma (FL), surface immunoglobulin (sIg) carries mandatory N-glycosylation sites in the variable regions, inserted during somatic hypermutation. These glycosylation sites are tumor-specific, indicating a critical function in
Externí odkaz:
https://doaj.org/article/0f9b4c5e32fc4b8ab9e5de05992b58d9
Autor:
Nicholas Chiorazzi, Freda K. Stevenson
Publikováno v:
HemaSphere, Vol 4, Iss 1, p e334 (2020)
Abstract. The division of CLL into 2 broad subsets with highly significant differences in clinical behavior was reported in 2 landmark papers in Blood in 1999.1,2 The simple analysis of the mutational status of the IGV regions provided both a prognos
Externí odkaz:
https://doaj.org/article/858c68865d2646e684117dfba938e92f
Autor:
Andrew J. Steele, Jan A. Burger, Greg P. Coffey, Francesco Forconi, Graham Packham, Freda K. Stevenson, Jonathan C. Strefford, Anjali Pandey, Pamela B. Conley, Peter W.M. Johnson, Andrew Davies, Lindsay D. Smith, Jack Parnell, Alice Hayman, Sarah Wilmore, Marta Larrayoz, Rachel C. Dobson, Stefan Koehrer, Matthew D. Blunt
Supplementary methods and Figures Supplementary Figure 1. Effect of cerdulatinib on Immobilised anti-IgM mediated signaling Supplementary Figure 2. Effect of cerdulatinib on soluble anti-IgM mediated signaling Supplementary Figure 3. Effect of cerdul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a468e825532cc2770eba48a39c5394f7
https://doi.org/10.1158/1078-0432.22463541
https://doi.org/10.1158/1078-0432.22463541
Autor:
Francesco Forconi, Freda K. Stevenson, Graham Packham, Andrew J. Steele, Livio Trentin, Peter W. Johnson, Ian Tracy, Annalisa D'Avola, Giorgia Chiodin, Samantha Drennan
Purpose:In chronic lymphocytic leukemia (CLL), disease progression associates with surface IgM (sIgM) levels and signaling capacity. These are variably downmodulated in vivo and recover in vitro, suggesting a reversible influence of tissue-located an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d48044b2377dccbafbdf0dcea6600a8
https://doi.org/10.1158/1078-0432.c.6528189
https://doi.org/10.1158/1078-0432.c.6528189
Autor:
Andrew J. Steele, Jan A. Burger, Greg P. Coffey, Francesco Forconi, Graham Packham, Freda K. Stevenson, Jonathan C. Strefford, Anjali Pandey, Pamela B. Conley, Peter W.M. Johnson, Andrew Davies, Lindsay D. Smith, Jack Parnell, Alice Hayman, Sarah Wilmore, Marta Larrayoz, Rachel C. Dobson, Stefan Koehrer, Matthew D. Blunt
Purpose: B-cell receptor (BCR)–associated kinase inhibitors, such as ibrutinib, have revolutionized the treatment of chronic lymphocytic leukemia (CLL). However, these agents are not curative, and resistance is already emerging in a proportion of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65982893f3a24771c803dc31b3ed3e60
https://doi.org/10.1158/1078-0432.c.6525432
https://doi.org/10.1158/1078-0432.c.6525432
Autor:
Graham Packham, Pavel Klener, Lloyd Mackenzie, Jennifer Cross, Andrew J. Steele, Francesco Forconi, Mark Cragg, Freda K. Stevenson, Curtis Harwig, Jeremy Pettigrew, Georg Lenz, Chris T. Williamson, Laura Karydis, Nicola J. Weston-Bell, Karel Helman, Michael Svaton, Jana Karolova, Matthew J. Carter, Yohannes Gebreselassie, Johanna Richter, Lindsay D. Smith, Beatriz Valle-Argos, Elizabeth A. Lemm
Supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067d77f6406b11ba2ff53f0855ef08b2
https://doi.org/10.1158/1078-0432.22478181
https://doi.org/10.1158/1078-0432.22478181
Autor:
Francesco Forconi, Freda K. Stevenson, Graham Packham, Andrew J. Steele, Livio Trentin, Peter W. Johnson, Ian Tracy, Annalisa D'Avola, Giorgia Chiodin, Samantha Drennan
Supplementary Tables S1-S2 and Figures S1-S4 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37476898a6b2f9de79ed9274e267d98d
https://doi.org/10.1158/1078-0432.22472301
https://doi.org/10.1158/1078-0432.22472301
Autor:
Christian H. Ottensmeier, Freda K. Stevenson, Gareth J. Thomas, Ugur Sahin, Petra Simon, Toni Weinschenk, Duncan I. Jodrell, Alan Anthoney, Sally Clive, Ann O'Callaghan, Andrew Bateman, Sarah Halford, Ceri Edwards, Emily Buxton, Paul Lloyd-Evans, Andrew King, Stephen M. Thirdborough, Jana Stasakova, Lindsey Chudley, Angelica Cazaly, Ann Mander, Katy J. McCann
Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus toxin.Experimental Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4202489da8884143afe28a39cda33e82
https://doi.org/10.1158/1078-0432.c.6524756.v1
https://doi.org/10.1158/1078-0432.c.6524756.v1
Autor:
Andrew J. Steele, Freda K. Stevenson, Joe Taylor, Mark J. Coldwell, Graham Packham, Sarah Wilmore, Elizabeth Lemm, Alison Yeomans, Francesco Forconi, Rachel Fell, Karly-Rai Rogers-Broadway
Publikováno v:
Cellular and Molecular Life Sciences
Signaling via the B-cell receptor (BCR) is a key driver and therapeutic target in chronic lymphocytic leukemia (CLL). BCR stimulation of CLL cells induces expression of eIF4A, an initiation factor important for translation of multiple oncoproteins, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bb8b1f4d8bff40a8702adbd37299e5
https://doi.org/10.1007/s00018-021-03910-x
https://doi.org/10.1007/s00018-021-03910-x