Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Freda F. Li"'
Publikováno v:
Organic & Biomolecular Chemistry. 21:1222-1234
This work details a novel approach to access the [7,6]-spirocyclic fragment of 13-desmethyl spirolide C. A more efficient synthesis of the key lactam dienophile is reported, and a comprehensive investigation of the Diels-Alder reaction is included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f38970b6aa5f5b88a9398542a6171f1b
https://doi.org/10.1039/d2ob01992b
https://doi.org/10.1039/d2ob01992b
Autor:
Margaret A. Brimble, Geoffrey M. Williams, Freda F. Li, Inken D. Kelch, P. Rod Dunbar, Benjamin L. Lu
Publikováno v:
European Journal of Organic Chemistry. 2021:5415-5423
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b505b77abef9f482fe24a37de4a249
https://doi.org/10.1002/ejoc.202101055
https://doi.org/10.1002/ejoc.202101055
Publikováno v:
Synlett. 31:657-671
Cyclic imine marine toxins have attracted considerable attention from the synthetic community in the past two decades due to their unique chemical structures and clinically relevant biological activities. This review presents recent efforts of our gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7d727c1788ef8717957852f8f333f41
https://doi.org/10.1055/s-0039-1691593
https://doi.org/10.1055/s-0039-1691593
Autor:
Wang, Zifei L, Freda F, Li, Quach, Rachelle, Ferrarese, Alessandro, Forgiarini, Alessia, Ferrari, Mauro, D'Amore, Claudio, Bova, Sergio, Orso, Genny, Fusi, Fabio, Saponara, Simona, Hopkins, Brian, Brimble, Margaret A, Rennison, David
Publikováno v:
Bioorganicmedicinal chemistry. 59
Norbormide [5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats, but relatively harmless to other rodents and mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc56ee00d9152f1084470415ba812c7
https://pubmed.ncbi.nlm.nih.gov/35202967
https://pubmed.ncbi.nlm.nih.gov/35202967
Autor:
Shengping Zhang, Luis M. De Leon Rodriguez, Freda F. Li, Renjie Huang, Ivanhoe K. H. Leung, Paul W. R. Harris, Margaret A. Brimble
Publikováno v:
Chemical science. 13(9)
A novel tyrosine hyperoxidation enabling selective peptide cleavage is reported. The scission of the N-terminal amide bond of tyrosine was achieved with Dess-Martin periodinane under mild conditions, generating a C-terminal peptide fragment bearing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379b7f16d1ad550c44b6004d848bfdf0
https://pubmed.ncbi.nlm.nih.gov/35356671
https://pubmed.ncbi.nlm.nih.gov/35356671
Publikováno v:
Journal of Natural Products. 82:2054-2065
Natural products containing a lumazine motif were first isolated from natural sources in 1940. These natural products are relatively rare, with fewer than 100 lumazines known to occur in Nature. This review discusses the isolation of lumazines, their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e69658605560326fbe8f83f531f0d17
https://doi.org/10.1021/acs.jnatprod.9b00351
https://doi.org/10.1021/acs.jnatprod.9b00351
Autor:
Freda F. Li, Margaret A. Brimble
Publikováno v:
Pure and Applied Chemistry. 91:181-198
The emergence of multidrug-resistant bacteria has necessitated the urgent need for novel antibacterial agents. Antimicrobial peptides (AMPs), the host-defence molecules of most living organisms, have shown great promise as potential antibiotic candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae4799faf638687c40ddae8964a14a8
https://doi.org/10.1515/pac-2018-0704
https://doi.org/10.1515/pac-2018-0704
Autor:
Andrew D. Harper, Melanie K. Knottenbelt, Joo Young Jeong, Essie M. Van Zuylen, Greg F. Walker, Freda F. Li, Sonya Mros, Emma K. Davison, Gregory M. Cook, Nichaela Harbison-Price, John E. McGowan, Adam Heikal, Scott A. Ferguson, David Rennison, Margaret A. Brimble, Woravimol Krittaphol, Michelle McConnell
Publikováno v:
Bioorganicmedicinal chemistry. 29
A series of C-2 derivatized 8-sulfonamidoquinolines were evaluated for their antibacterial activity against the common mastitis causative pathogens Streptococcus uberis, Staphylococcus aureus and Escherichia coli, both in the presence and absence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787ceeea99a04082b56bcade3e14fe77
https://pubmed.ncbi.nlm.nih.gov/33223463
https://pubmed.ncbi.nlm.nih.gov/33223463
Autor:
Jeff B. Smaill, Freda F. Li, Adam V. Patterson, Louise A. Stubbing, Margaret A. Brimble, Paul W. R. Harris, Maria R. Abbattista, Iman Kavianinia
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(16)
Culicinin D (1), a 10 amino acid peptaibol containing several unusual residues, has been shown to exhibit potent anticancer activity. Previous work in our group towards developing a structure-activity relationship (SAR) for this peptaibol has concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb552976aed06bdb8712dfc45a54737
https://pubmed.ncbi.nlm.nih.gov/32631536
https://pubmed.ncbi.nlm.nih.gov/32631536
Autor:
Zifei Wang, Andrea Pagetta, David Rennison, Freda F. Li, Brian Hopkins, Claudio D'Amore, Margaret A. Brimble, Sara Bersani, Morgan Jay-Smith, Genny Orso, Alessia Forgiarini, S. De Martin, Sergio Bova, Barbara Napoli
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0211169 (2019)
PLoS ONE, Vol 14, Iss 4, p e0211169 (2019)
In this study we investigated the performance of two norbormide (NRB)-derived fluorescent probes, NRBMC009 (green) and NRBZLW0047 (red), on dissected, living larvae of Drosophila, to verify their potential application in confocal microscopy imaging i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2f57855a7428d94daf3d611122ef61
http://hdl.handle.net/11577/3295242
http://hdl.handle.net/11577/3295242
