Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Freda E.-C. Jen"'
Autor:
Michael A. Apicella, Jennifer L. Edwards, Margaret R. Ketterer, David S. Weiss, Yuan Zhang, Freda E.-C. Jen, Michael P. Jennings
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Contact-dependent hemolysins are virulence factors in a number of human pathogens, including Helicobacter pylori, Rickettsia typhi, Bartonella bacilliformis, Mycobacterium tuberculosis, entero-invasive Escherichia coli, and Shigella. Here we
Externí odkaz:
https://doaj.org/article/b83cc134a9e54f84ae257adcedf8062e
Autor:
Christopher J. Day, Paola Favuzza, Sabrina Bielfeld, Thomas Haselhorst, Leonie Seefeldt, Julia Hauser, Lucy K. Shewell, Christian Flueck, Jessica Poole, Freda E.-C. Jen, Anja Schäfer, Jean-Pierre Dangy, Tim-W. Gilberger, Camila Tenorio França, Manoj T. Duraisingh, Marco Tamborrini, Nicolas M.B. Brancucci, Christof Grüring, Michael Filarsky, Michael P. Jennings, Gerd Pluschke
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114012- (2024)
Summary: Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex protein essential for erythrocyte invasion. The pr
Externí odkaz:
https://doaj.org/article/b1552435879b4808a30ae832a3d6786d
Autor:
Greg Tram, Freda E.-C. Jen, Zachary N. Phillips, John F. Lancashire, Jamie Timms, Jessica Poole, Michael P. Jennings, John M. Atack
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Haemophilus influenzae biogroup aegyptius is the causative agent of Brazilian purpuric fever (BPF), an invasive disease with high mortality, that sporadically manifests in children previously suffering conjunctivitis. Though strains of H. in
Externí odkaz:
https://doaj.org/article/bb3c4b220b9b4758b57325e22dd20940
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Many bacterial surface proteins and carbohydrates are modified with phosphorylcholine (ChoP), which contributes to host mimicry and can also promote colonization and survival in the host. However, the ChoP biosynthetic pathways that are used
Externí odkaz:
https://doaj.org/article/a7baa9770efb479ab5d93dd074909afa
Autor:
Joanna E. Musik, Jessica Poole, Christopher J. Day, Thomas Haselhorst, Freda E.-C. Jen, Thomas Ve, Veronika Masic, Michael P. Jennings, Yaramah M. Zalucki
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Escherichia coli signal peptidase I (LepB) has been shown to inefficiently cleave secreted proteins with aromatic amino acids at the second position after the signal peptidase cleavage site (P2′). The Bacillus subtilis exported protein Tas
Externí odkaz:
https://doaj.org/article/d352345c81ca42e69915574c0c5eb31d
Autor:
Kevin S. Johnson, Bassam A. Elgamoudi, Freda E.-C. Jen, Christopher J. Day, Emily Goers Sweeney, Megan L. Pryce, Karen Guillemin, Thomas Haselhorst, Victoria Korolik, Karen M. Ottemann
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The Helicobacter pylori chemoreceptor TlpA plays a role in dampening host inflammation during chronic stomach colonization. TlpA has a periplasmic dCache_1 domain, a structure that is capable of sensing many ligands; however, the only charac
Externí odkaz:
https://doaj.org/article/958587dd065b4f2d967bac45ac018790
Autor:
Greg Tram, Freda E.-C. Jen, Zachary N. Phillips, Jamie Timms, Asma-Ul Husna, Michael P. Jennings, Patrick J. Blackall, John M. Atack
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
Streptococcus suisS. suis
Externí odkaz:
https://doaj.org/article/3e51077cd21f4c13ae1cb07ba7534ec0
Autor:
Christopher J. Day, Benjamin Bailly, Patrice Guillon, Larissa Dirr, Freda E.-C. Jen, Belinda L. Spillings, Johnson Mak, Mark von Itzstein, Thomas Haselhorst, Michael P. Jennings
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.
Externí odkaz:
https://doaj.org/article/2b06afb56d02402cb0d88feb912f1af0
Autor:
Freda E.-C. Jen, Margaret R. Ketterer, Evgeny A. Semchenko, Christopher J. Day, Kate L. Seib, Michael A. Apicella, Michael P. Jennings
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
ABSTRACT The lipooligosaccharide (LOS) of Neisseria gonorrhoeae plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process of phase variation and by differences in the glycosyltransf
Externí odkaz:
https://doaj.org/article/e792e6f0b6e749d4b2e0efbf84976f51
Autor:
Jessica Poole, Christopher J. Day, Thomas Haselhorst, Freda E.-C. Jen, Victor J. Torres, Jennifer L. Edwards, Michael P. Jennings
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT In the absence of a vaccine, multidrug-resistant Neisseria gonorrhoeae has emerged as a major human health threat, and new approaches to treat gonorrhea are urgently needed. N. gonorrhoeae pili are posttranslationally modified by a glycan th
Externí odkaz:
https://doaj.org/article/1fed3e7d06824e47b917fbd3f86a0f24