Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Freda C. D. Sheppard"'
Autor:
Louisa M. Brown, Kaye J. Williams, Freda C. D. Sheppard, Camille Debray, Amanda Eustace, Janine T. Erler, Ian J. Stratford, Rachel L. Cowen, Catriona Parker
Publikováno v:
Molecular Pharmacology. 69:411-418
The resistance of hypoxic cells to conventional chemotherapy is well documented. Using both adenovirus-mediated gene delivery and small molecules targeting hypoxia-inducible factor-1 (HIF-1), we evaluated the impact of HIF-1 inhibition on the sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b05dbd3715255e1248e0c4d84c36c4d
https://doi.org/10.1124/mol.105.015743
https://doi.org/10.1124/mol.105.015743
Autor:
Ian J. Stratford, Simon D. Scott, Adam V. Patterson, Freda C. D. Sheppard, Rachel L. Cowen, Suzanne Robinson, Naomi Chadderton, Kaye J. Williams, Olga Greco
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 62:213-222
Purpose: Tumor hypoxia is unequivocally linked to poor radiotherapy outcome. This study aimed to identify enhancer sequences that respond maximally to a combination of radiation and hypoxia for use in genetic radiotherapy approaches. Methods and mate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7048ee800b492454d122774fc92c795
https://doi.org/10.1016/j.ijrobp.2005.01.031
https://doi.org/10.1016/j.ijrobp.2005.01.031
Autor:
E Chinje, Ian J. Stratford, Kaye J. Williams, Rachel L. Cowen, Freda C. D. Sheppard, Natasha S. Wind, Mohammed Jaffar, Brian A. Telfer
Publikováno v:
Cancer Research. 64:1396-1402
Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this resistant population, bioreductive drugs that are preferentially toxic to tumor cells in a hypoxic environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ef13c278c17a59f024017d616b9d36
https://doi.org/10.1158/0008-5472.can-03-2698
https://doi.org/10.1158/0008-5472.can-03-2698
Autor:
Rachel L, Cowen, Kaye J, Williams, Edwin C, Chinje, Mohammed, Jaffar, Freda C D, Sheppard, Brian A, Telfer, Natasha S, Wind, Ian J, Stratford
Publikováno v:
Cancer research. 64(4)
Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this resistant population, bioreductive drugs that are preferentially toxic to tumor cells in a hypoxic environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0325fa66c7b657a6c2d11bcfb1b7a631
https://pubmed.ncbi.nlm.nih.gov/14973055
https://pubmed.ncbi.nlm.nih.gov/14973055