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Akademický článek

The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Mineralocorticoid-Induced Renal Injury

Autor: Frédéric Jaisser, Xiaojuan Tan, Shuangshuang Chi, Jinrong Liu, Ping Wang, Mark Bush, Vincent Benn, Y. Fred Yang, Jay Zhang

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The therapeutic indices (TIs) and efficacy of the non-steroidal mineralocorticoid receptor antagonist (MRA) KBP-5074 and steroidal MRA eplerenone were evaluated in a uninephrectomized Sprague Dawley rat model of aldosterone-mediated renal disease. In

Externí odkaz: https://doaj.org/article/70307f2212d94cf0ada186684e06954e

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Akademický článek

Successful treatment of tocilizumab and ivermectin for a patient with ARDS due to COVID-19

Autor: Tzu-Yi Chuang, Ming-Han Tsai, Lit-Min Wu, Sung-Jung Ho, Pu-Sheng Yeh, Yi-Lien Liu, Hung-Jen Fred Yang

Publikováno v: Journal of Microbiology, Immunology and Infection, Vol 54, Iss 1, Pp 147-148 (2021)

Externí odkaz: https://doaj.org/article/ab539cd27d5a40bdaa400e4583e4dd8d

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Effect of KBP-5074 on Blood Pressure in Advanced Chronic Kidney Disease: Results of the BLOCK-CKD Study

Autor: Pablo E. Pergola, Nam Vo, Tamar Doliashvili, Belkis Delgado, James McCabe, Y. Fred Yang, Diyan Genov, George L. Bakris, Bertram Pitt, Vincent Benn

Publikováno v: Hypertension (Dallas, Tex. : 1979)

Supplemental Digital Content is available in the text.
In patients with resistant or poorly controlled hypertension and advanced chronic kidney disease, mineralocorticoid receptor antagonists are recommended; however, hyperkalemia limits their u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0856db64f265df1ac64c3be6d71f25
https://doi.org/10.1161/hypertensionaha.121.17073

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Autor: Jay Zhang, Vincent Benn, Mark Bush, Y. Fred Yang, Shuangshuang Chi, Ping Wang, Jinrong Liu, Xiaojuan Tan, Frederic Jaisser

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Frontiers, 2021, 12, ⟨10.3389/fphar.2021.604928⟩
Frontiers in Pharmacology, Vol 12 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c065ebc8bd5e1f1804a38449087fb2d
https://hal.sorbonne-universite.fr/hal-03285721/file/fphar-12-604928.pdf

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Mineralocorticoid Receptor Antagonists for Hypertension Management in Advanced Chronic Kidney Disease: BLOCK-CKD Trial

Autor: Bertram Pitt, Y. Fred Yang, George L. Bakris

Publikováno v: Hypertension (Dallas, Tex. : 1979). 76(1)

Spironolactone, a steroidal mineralocorticoid receptor antagonist, is recommended as add-on therapy for treatment-resistant/uncontrolled hypertension. However, caution is advised in patients with advanced chronic kidney disease (CKD) due to an increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e430a0806d1b8f6fd0f2ac3996a41ef
https://pubmed.ncbi.nlm.nih.gov/32520623

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Successful treatment of tocilizumab and ivermectin for a patient with ARDS due to COVID-19

Autor: Sung-Jung Ho, Ming-Han Tsai, Lit-Min Wu, Pu-Sheng Yeh, Tzu-Yi Chuang, Yi-Lien Liu, Hung-Jen Fred Yang

Publikováno v: Journal of Microbiology, Immunology, and Infection
Journal of Microbiology, Immunology and Infection
Journal of Microbiology, Immunology and Infection, Vol 54, Iss 1, Pp 147-148 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57261f43016e18ac586c06e48c5719f4
https://pubmed.ncbi.nlm.nih.gov/34756359

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Nonclinical Pharmacokinetics, Protein Binding, and Elimination of KBP-7072, an Aminomethylcycline Antibiotic, in Animal Models

Autor: Jay Zhang, Tian Zhou, Yuanju Zhu, Qingmei Liu, Min Zhang, Vincent Benn, Ping Wang, Xiaojuan Tan, Meng Wang, Bin Chen, Yong Xia, Fred Yang

Publikováno v: Antimicrobial Agents and Chemotherapy

KBP-7072 is a semisynthetic aminomethylcycline with broad-spectrum activity against Gram-positive and Gram-negative pathogens, including multidrug-resistant bacterial strains. The pharmacokinetics (PK) of KBP-7072 after oral and intravenous (i.v.) ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c7315b91594e80f9c2c04bb66cd25f
https://doi.org/10.1128/aac.00488-20

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Safety and Pharmacokinetics of a Novel Non-Steroidal Mineralocorticoid Receptor Antagonist, KBP-5074, in Hemodialysis and Non-Hemodialysis Patients with Severe Chronic Kidney Disease

Autor: Mark Bush, Vincent Benn, Fred Yang, Jinrong Liu, Ping Wang, Jon Ruckle, Min Zhang, Jeffrey Connaire, Xiaojuan Tan, Tian Zhou

ObjectiveKBP-5074 is a novel non-steroidal mineralocorticoid receptor antagonist for the potential treatment of hypertension. The purpose of this study was to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single dose of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc63ea95666674af14e92285ae4b5e99
https://doi.org/10.1101/2020.05.12.20053314

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In VivoEfficacy and PK/PD Modeling of KBP-7072, An Aminomethylcycline Antibiotic, in Neutropenic Pneumonia and Thigh Infection Models

Autor: Vincent Benn, Min Zhang, Tian Zhou, Ping Wang, Qingmei Liu, Xiaojuan Tan, Fred Yang

KBP-7072 is a novel aminomethylcycline with broad-spectrum activity against Gram-positive and Gram-negative multidrug resistant bacterial isolates and strains.Antibacterial activity and the PK/PD relationship were assessed usingin vivoinfection model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0c4da0ef0e03fbc6c710ad3400e830
https://doi.org/10.1101/2020.03.18.998112

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