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Akademický článek

Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice

Autor: Jong Huat Tee, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y. W. Lam, Wupeng Liao, Yuansheng Yang, W. S. Fred Wong, Ruowen Ge

Publikováno v: Respiratory Research, Vol 24, Iss 1, Pp 1-20 (2023)

Abstract Background Allergic asthma is a common respiratory disease that significantly impacts human health. Through in silico analysis of human lung RNASeq, we found that asthmatic lungs display lower levels of Isthmin-1 (ISM1) expression than healt

Externí odkaz: https://doaj.org/article/923845b45d43484390c4c1f41b610c0a

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Akademický článek

Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism

Autor: Phyllis X.L. Gan, Wupeng Liao, Hui Fang Lim, W.S. Fred Wong

Publikováno v: Pharmacological Research, Vol 196, Iss , Pp 106929- (2023)

Severe asthma is a difficult-to-treat chronic airway inflammatory disease requiring systemic corticosteroids to achieve asthma control. It has recently been shown that drugs targeting immunometabolism have elicited anti-inflammatory effects. The purp

Externí odkaz: https://doaj.org/article/b9c3115bd4734d8cb7e24b8d175da919

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Akademický článek

Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy

Autor: Quy T.N. Tran, Phyllis X.L. Gan, Wupeng Liao, Yu Keung Mok, Christina L.L. Chai, W.S. Fred Wong

Publikováno v: Pharmacological Research, Vol 194, Iss , Pp 106861- (2023)

The p38MAPK-MK2 signaling axis functions as an initiator of inflammation. Targeting the p38MAPK-MK2 signaling axis represents a direct therapeutic intervention of inflammatory diseases. We described here a novel role of andrographolide (AG), a small-

Externí odkaz: https://doaj.org/article/fc9e6c19302c4d7f9cff817171450cde

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Akademický článek

ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice

Autor: Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong, Ruowen Ge

Publikováno v: Molecular Medicine, Vol 28, Iss 1, Pp 1-17 (2022)

Abstract Background Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are clinical syndromes characterized by acute lung inflammation, pulmonary edema and hypoxemia, with up to 50% mortality rate without effective pharmacological thera

Externí odkaz: https://doaj.org/article/927c92e62e31416ea54972d2ff82f5bf

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Akademický článek

Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma

Autor: Andrew Li, Hiang Ping Chan, Phyllis X.L. Gan, Mei Fong Liew, W.S. Fred Wong, Hui-Fang Lim

Publikováno v: The Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1305-1319 (2021)

Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and

Externí odkaz: https://doaj.org/article/73dee75f007948f68c61dda89afb3cae

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Akademický článek

Ribosomal Protein S3 Gene Silencing Protects Against Cigarette Smoke-Induced Acute Lung Injury

Autor: Jinrui Dong, Wupeng Liao, Hong Yong Peh, W.S. Daniel Tan, Shuo Zhou, W.S. Fred Wong

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 370-380 (2018)

Chronic obstructive pulmonary disease (COPD) is estimated to be the third leading cause of death by 2030. Transcription factor NF-κB may play a critical role in COPD pathogenesis. Ribosomal protein S3 (RPS3), a 40S ribosomal protein essential for ex

Externí odkaz: https://doaj.org/article/38c9458d761946dbb1ccf5ec1184804c

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