Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Fred Widmer"'
Autor:
Fred Widmer, Xiaoming Zuo, Daniel Obando, Katrina A. Jolliffe, Julianne T. Djordjevic, Johanes Bijosono Oei, Yasuko Koda, Namfon Pantarat, Sophie Lev, Tania C. Sorrell
Publikováno v:
ChemMedChem. 13:1421-1436
A series of bis(4-pentylpyridinium) compounds with a variety of spacers between the pyridinium headgroups was synthesised, and the antifungal activity of these compounds was investigated. Lengthening the alkyl spacer between the pentylpyridinium head
Autor:
Chayanika Biswas, Katrina A. Jolliffe, Namfon Pantarat, David Ellis, Fred Widmer, Sharon C.-A. Chen, Tania C. Sorrell, Julianne T. Djordjevic, Robyn Bartley, Daniel Obando
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:3233-3240
Ten bis(alkylpyridinium)alkane compounds were tested for antifungal activity against 19 species (26 isolates) of yeasts and molds. We then determined the MICs and minimum fungicidal concentrations (MFCs) of four of the most active compounds (compound
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5158-5165
The antifungal, antibacterial and haemolytic activity of a series of alkylphosphocholines (e.g., miltefosine) and alkylglycerophosphocholines (e.g., edelfosine) has been investigated. These compound classes exhibit significant antifungal and moderate
Autor:
Fanrong Kong, Katrina A. Jolliffe, Fred Widmer, Sharon C.-A. Chen, Zhongsheng Tong, Catriona Halliday, Zofia Guse, Ok Cha Lee, Lesley C. Wright, Tania C. Sorrell
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2219-2222
The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB,
Publikováno v:
Microbes and Infection. 8:1006-1015
Secreted phospholipase B (PLB1), which contains three enzyme activities in the one protein, is necessary for the initiation of pulmonary infection by Cryptococcus neoformans and for dissemination from the lung via the lymphatics and blood. Adhesion t
Autor:
Lesley C. Wright, Tania C. Sorrell, Fred Widmer, Ranjini Ganendren, Daniel Obando, Rosemary Handke, David Ellis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:414-421
The alkyl phosphocholine drug miltefosine is structurally similar to natural substrates of the fungal virulence determinant phospholipase B1 (PLB1), which is a potential drug target. We determined the MICs of miltefosine against key fungal pathogens,
Autor:
Katrina A. Jolliffe, Fred Widmer, Lesley C. Wright, Tania C. Sorrell, Clarissa K. L. Ng, Daniel Obando
Publikováno v:
Journal of Medicinal Chemistry. 49:811-816
A series of bisquaternary ammonium salts with a 12-carbon spacer between the positive charges were synthesized, and their antifungal activity has been investigated. Compounds with butyl, pentyl, and isopentyl headgroups were the most potent antifunga
Autor:
Rosemary T. Santangelo, Mukoma F. Simpanya, Lesley C. Wright, Tania C. Sorrell, Sharon C.-A. Chen, Fred Widmer, Jackie Payne
Publikováno v:
Biochemical Journal. 384:377-384
The pathogenic fungus Cryptococcus neoformans produces an extracellular PLB1 (phospholipase B1), shown previously to be a virulence factor. A novel phospholipase (LPL1) with only LPL (lysophospholipase) and LPTA (transacylase) activities has now been
Autor:
Qi Yang, Ross A. Davey, Mary W. Davey, Craig L. Francis, Robert George Whittaker, Xanthe E Wells, Minoo J. Moghaddam, Hua-Ming Williams, Fred Widmer, Karen V Cullen
Publikováno v:
British Journal of Pharmacology. 137:1280-1286
1. Increasing the lipophilicity is a strategy often used to improve a compound's cellular uptake and retention but this may also convert it into a substrate for an ATP-dependent transporter such as P-glycoprotein or the multidrug resistance-associate
Autor:
Julie M Fraser, Fred Widmer, Qi Yang, Maree O'Sullivan, Clayton E Walton, Craig L. Francis, Xanthe E Wells, Catherine Walker, Robert George Whittaker
Publikováno v:
Journal of Drug Targeting. 10:479-487
Tris-lipidation uses Tris to produce drug-fatty acyl conjugates. Radiolabelled Tris-fatty acyl conjugates of methotrexate (MTX) were examined in biodistribution studies in BALB/c mice. Following delivery via a variety of routes, the Tris-lipidated co