Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Fred W. Van Leeuwen"'
Autor:
Inbal Maniv, Mahasen Sarji, Anwar Bdarneh, Alona Feldman, Roi Ankawa, Elle Koren, Inbar Magid-Gold, Noa Reis, Despina Soteriou, Shiran Salomon-Zimri, Tali Lavy, Ellina Kesselman, Naama Koifman, Thimo Kurz, Oded Kleifeld, Daniel Michaelson, Fred W. van Leeuwen, Bert M. Verheijen, Yaron Fuchs, Michael H. Glickman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is characterized by toxic protein accumulation in the brain. Ubiquitination is essential for protein clearance in cells, making altered ubiquitin signaling crucial in AD development. A defective variant, ubiquitin
Externí odkaz:
https://doaj.org/article/74e57d7f81c342d092153d856a153d11
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-3 (2017)
Externí odkaz:
https://doaj.org/article/600bdfdaef494572b0a8e94d9727c8e7
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Guam parkinsonism–dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism. Neuropathologicall
Externí odkaz:
https://doaj.org/article/0a291663a58f479fae9bae4fd6ac6a9e
Autor:
Bert M. Verheijen, Fred W. van Leeuwen
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/01b8dd0f6da144048e1eb0fbb32ab246
Autor:
Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1557-1571 (2015)
Neuronal accumulation of UBB+1, a frameshift variant of ubiquitin B, is a hallmark of Alzheimer’s disease (AD). How UBB+1 contributes to neuronal dysfunction remains elusive. Here, we show that in brain regions of AD patients with neurofibrillary t
Externí odkaz:
https://doaj.org/article/82827895d6f54a068f30299b67cf92a1
Autor:
Ashok N. Hegde, Fred W. van Leeuwen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Externí odkaz:
https://doaj.org/article/775571d153c74c55800cff5988dd4bfc
Autor:
Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo
Publikováno v:
Microbial Cell, Vol 2, Iss 4, Pp 136-138 (2015)
Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB+1, the frameshift variant of ubiquitin B, accumu
Externí odkaz:
https://doaj.org/article/d3db5e16de364cd0aa782086fbc8062a
Autor:
Romina Jozefa Gentier, Bert M. Verheijen, Margherita eZamboni, Maartje M.A. Stroeken, Denise J.H.P. Hermes, Benno eKusters, Harry Wilhelm Maria Steinbusch, David A. Hopkins, Fred W. Van Leeuwen
Publikováno v:
Frontiers in Neuroanatomy, Vol 9 (2015)
Loss of protein quality control by the ubiquitin-proteasome system (UPS) during aging is one of the processes putatively contributing to cellular stress and Alzheimer’s disease (AD) pathogenesis. Recently, pooled Genome Wide Association Studies (GW
Externí odkaz:
https://doaj.org/article/8caf65a0fe4240bb8e752b69878ca9f4
Autor:
Yasumasa Kokubo, Satoru Morimoto, Kiyomitsu Oyanagi, Bert M. Verheijen, Ryogen Sasaki, Fred W. van Leeuwen, Shigeki Kuzuhara
Publikováno v:
Journal of Neuropathology and Experimental Neurology, 79(8), 902-907. LIPPINCOTT WILLIAMS & WILKINS
Journal of Neuropathology and Experimental Neurology, 79, 902-907. Lippincott Williams & Wilkins
Journal of Neuropathology and Experimental Neurology, 79, 902-907. Lippincott Williams & Wilkins
Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder that is endemic to the Kii peninsula of Japan. The disorder is clinically characterized by a variable combination of parkinsonism, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d782af081c3381d41522c35963aba9
https://cris.maastrichtuniversity.nl/en/publications/214b3739-2a54-45d7-b70d-6ce8b3386834
https://cris.maastrichtuniversity.nl/en/publications/214b3739-2a54-45d7-b70d-6ce8b3386834
Autor:
Fred W. van Leeuwen, Ralph M. Garruto, Cora Müller-Hübers, Celina Lussier, Bert M. Verheijen, Kiyomitsu Oyanagi, Ralf J. Braun
Publikováno v:
Journal of Neuropathology & Experimental Neurology, 79, 34-45. Lippincott Williams & Wilkins
Journal of Neuropathology and Experimental Neurology, 79(1), 34-45. LIPPINCOTT WILLIAMS & WILKINS
Journal of Neuropathology and Experimental Neurology, 79(1), 34-45. LIPPINCOTT WILLIAMS & WILKINS
Guam parkinsonism-dementia (G-PD) is a progressive and fatal neurodegenerative disorder among the native inhabitants of the Mariana Islands that manifests clinically with parkinsonism as well as dementia. Neuropathologically, G-PD is characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046759cee9bc296281f3dc2a1a582782
https://pure.knaw.nl/portal/en/publications/f915a3be-92e9-478a-b2be-8ebbb2d59d32
https://pure.knaw.nl/portal/en/publications/f915a3be-92e9-478a-b2be-8ebbb2d59d32