Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Fred W, Keeley"'
Autor:
Yuuta Moriyama, Fumihiro Ito, Hiroyuki Takeda, Tohru Yano, Masataka Okabe, Shigehiro Kuraku, Fred W. Keeley, Kazuko Koshiba-Takeuchi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The bulbus arteriosus is an organ unique to the heart of teleosts, composed of specialized smooth muscle. Here, the authors show that the gene elastin b, which regulates cell fate of cardiac precursor cells into smooth muscle, evolved after whole-gen
Externí odkaz:
https://doaj.org/article/b5e5ddf237544ca2aa051a7f36b5a662
Autor:
Milica Radisic, James Ellis, Deivid C. Rodrigues, Tadeo Thompson, Caroline Kinnear, Fred W. Keeley, Aric Pahnke, Samad Ahadian, Caitlin Loo, Rahul Agrawal, Oyediran Akinrinade, Seema Mital
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells–derived SMCs can model
Objective: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells–derived SMCs can model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019bc59c2fdd693bb3ce333b4f190a21
https://doi.org/10.1161/atvbaha.119.313936
https://doi.org/10.1161/atvbaha.119.313936
Publikováno v:
Matrix Biology. 84:68-80
Elastin is the polymeric protein responsible for the physiologically important properties of extensibility and elastic recoil of cardiovascular, pulmonary and many other tissues. In spite of significant advances in the understanding how monomeric tro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6f3ea8ae4755e9057cd4d1fc86de6c
https://doi.org/10.1016/j.matbio.2019.06.010
https://doi.org/10.1016/j.matbio.2019.06.010
Autor:
Lisa D. Muiznieks, Fred W. Keeley
Publikováno v:
ACS biomaterials scienceengineering. 3(5)
Elastic biomaterials are found across biology where they fulfill diverse load-bearing and energy storage and dissipation functions. This class of biomaterials comprises elastic proteins that provide materials with combinations of extensibility, stiff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48f76931173ea51b5ecb166d7afa76b
https://pubmed.ncbi.nlm.nih.gov/33440501
https://pubmed.ncbi.nlm.nih.gov/33440501
Autor:
Régis Pomès, Eva E. Sitarz, Christopher Ing, Simon Sharpe, Sean E. Reichheld, Nick Wang, Lisa D. Muiznieks, Quang Huynh, Fred W. Keeley, Ming Miao
Publikováno v:
BiopolymersREFERENCES. 112(2)
Elastin is a major polymeric protein of the extracellular matrix, providing critical properties of extensibility and elastic recoil. The rs2071307 genomic polymorphism, resulting in the substitution of a serine for a glycine residue in a VPG motif in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9153a7e37016536955ac29914558dfd6
https://pubmed.ncbi.nlm.nih.gov/33351193
https://pubmed.ncbi.nlm.nih.gov/33351193
Genetic Diagnosis and the Severity of Cardiovascular Phenotype in Patients With Elastin Arteriopathy
Autor:
David Chiasson, Jade Bouwmeester, Seema Mital, Caroline Kinnear, Lisa C.A. D'Alessandro, Roderick Yao, Sandar Min, Fred W. Keeley
Publikováno v:
Circulation. Genomic and Precision Medicine
Supplemental Digital Content is available in the text.
Background: Elastin insufficiency causes recurrent vascular stenoses. Hemizygous deletion of the elastin gene (ELN) causes Williams-Beuren syndrome (WBS), while single nucleotide variants in
Background: Elastin insufficiency causes recurrent vascular stenoses. Hemizygous deletion of the elastin gene (ELN) causes Williams-Beuren syndrome (WBS), while single nucleotide variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5125eb1c0d13eaa415d7c89f7022ba
https://pubmed.ncbi.nlm.nih.gov/32960096
https://pubmed.ncbi.nlm.nih.gov/32960096
Autor:
David He, Ming Miao, Eva E Sitarz, Lisa D Muiznieks, Sean Reichheld, Richard J Stahl, Fred W Keeley, John Parkinson
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46130 (2012)
Elastin is a major structural component of elastic fibres that provide properties of stretch and recoil to tissues such as arteries, lung and skin. Remarkably, after initial deposition of elastin there is normally no subsequent turnover of this prote
Externí odkaz:
https://doaj.org/article/019c51074db1484ca69fa12ab39056e9
Publikováno v:
Journal of Molecular Biology. 430:4741-4753
Liquid-liquid phase separation resulting in formation of colloidal droplets has recently attracted attention as a mechanism for rapid and transient assembly of intracellular macromolecules into functional units. Phase separation also appears to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d41e1f23a8f485d2affb87c2c6ca96
https://doi.org/10.1016/j.jmb.2018.06.010
https://doi.org/10.1016/j.jmb.2018.06.010
Autor:
Wilson W L Sung, S. Mohsen Hosseini, Brett Trost, Stephen W. Scherer, John Wei, James Ellis, Jeffrey R. MacDonald, Sarah Bowdin, Janet A. Buchanan, M. Stephen Meyn, Miriam S. Reuter, Rohan V. Patel, Giovanna Pellecchia, Allison Hazell, Ryan A. Cook, Sergio L. Pereira, Bhooma Thiruvahindrapuram, Jennifer L. Howe, Iris Cohn, Lisa J. Strug, Ryan K. C. Yuen, Peter Pasceri, Yvonne Bombard, Joe Whitney, Hin C. Lee, Tara Paton, Anne S. Bassett, Rosanna Weksberg, Jill Davies, Barbara Kellam, Dimitri J. Stavropoulos, Wei Wei, Christian R. Marshall, Cheryl Shuman, Marc Fiume, Fred W. Keeley, Richard F. Wintle, Matthew R. Hildebrandt, Jo Anne Herbrick, Zhuozhi Wang, Peter N. Ray, Thomas Nalpathamkalam, Ronald D. Cohn, Sherilyn L. Bell, Neal Sondheimer, Daniele Merico, Susan Walker, Ann M. Joseph-George, Melanie M. Mahtani, Asli Romm, Chao Lu, Michael J. Szego, Nasim Monfared
Publikováno v:
Canadian Medical Association Journal. 190:E126-E136
BACKGROUND: The Personal Genome Project Canada is a comprehensive public data resource that integrates whole genome sequencing data and health information. We describe genomic variation identified in the initial recruitment cohort of 56 volunteers. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2df1093bd60b4a1ff0d0715877c4f3
https://doi.org/10.1503/cmaj.171151
https://doi.org/10.1503/cmaj.171151
Autor:
Lisa D. Muiznieks, Fred W. Keeley
Publikováno v:
Biopolymers. 105:693-703
Elastin and silk spidroins are fibrous, structural proteins with elastomeric properties of extension and recoil. While elastin is highly extensible and has excellent recovery of elastic energy, silks are particularly strong and tough. This study desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d74b3be8f8a50c6a523caa2f62df04c
https://doi.org/10.1002/bip.22888
https://doi.org/10.1002/bip.22888