In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

Autor: Lisa Woody, John F. Engelhardt, Annelotte M. Vonk, Yulong Zhang, Jaimie S. Gray, Xingshen Sun, Yaling Yi, Michael C. Winter, Shashanna R. Moll, Bradley H. Rosen, Dao M. Tran, Weihong Zhou, Ziying Yan, Paul A. Negulescu, Licong Jiang, Fred Van Goor, Bo Liang, Pavana G. Rotti, Jeffrey M. Beekman, Katherine N. Gibson-Corley, S. Park, T. Idil Apak Evans, Yu Yang, Dennis F. Fiorino

Publikováno v: Science Translational Medicine. 11

Cystic fibrosis (CF) is a multiorgan disease caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ). In patients with CF, abnormalities initiate in several organs before birth. However, the long-term impact of these i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fd531111541de40b4602751278d2c7
https://doi.org/10.1126/scitranslmed.aau7531

Simple model for laser-produced, mass-limited water-droplet plasmas

Autor: Jeroen Jonkers, Fred van Goor, Ralph Brummans, Joost van der Mullen, K Kurt Garloff, Michiel Van Den Donker

Publikováno v: Physical Review E-Statistical, Nonlinear, and Soft Matter Physics, 66(3), 036403-1/13. American Physical Society
Physical review E: Statistical, nonlinear, and soft matter physics, 66(3):036403. American Physical Society

Plasmas, produced by a neodymium yttrium aluminum garnet (Nd:YAG) laser pulse focused on a small water droplet and used for the generation of extreme ultraviolet light, can be described by a relatively simple model due to the fact that thermodynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef0dae2c7f64a3c3d5406f486979148
https://doi.org/10.1103/physreve.66.036403

Two-temperature model for pulsed-laser-induced subsurface modifications in Si.

Autor: Verburg, P.¹ p.c.verburg@utwente.nl, Römer, G.¹, Huis in 't Veld, A.

Publikováno v: Applied Physics A: Materials Science & Processing. Mar2014, Vol. 114 Issue 4, p1135-1143. 9p.

Event Brief of Vertex Pharmaceuticals Inc at UBS BioPharma Conference - Final

Publikováno v: Fair Disclosure Wire (Quarterly Earnings Reports). 11/09/2023.

Laying the Foundation for Cystic Fibrosis Therapy: An Interview with Michael Boyle.

Autor: Davies, Kevin

Publikováno v: Human Gene Therapy; Sep2020, Vol. 31 Issue 17-18, p917-920, 4p