Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Fred Schaper"'
Autor:
Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper, Anna Dittrich
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-19 (2021)
Abstract Background Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an essential mediator o
Externí odkaz:
https://doaj.org/article/3847bd43b88843ea8267e2c72dde37cb
Autor:
Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller, Fred Schaper
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-23 (2019)
Abstract Background Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for ne
Externí odkaz:
https://doaj.org/article/df55708c6ce449da8218667ca6d79df4
Autor:
Oliver Klepsch, Lise Sarah Namer, Nadine Köhler, Raymond Kaempfer, Anna Dittrich, Fred Schaper
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short and long isoform. He
Externí odkaz:
https://doaj.org/article/fe30643aa25e4834a6e08dfbb94c75ba
Autor:
Heike Reeh, Nadine Rudolph, Ulrike Billing, Henrike Christen, Stefan Streif, Eric Bullinger, Monica Schliemann-Bullinger, Rolf Findeisen, Fred Schaper, Heinrich J. Huber, Anna Dittrich
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-21 (2019)
Abstract Background Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalling is initiated by bi
Externí odkaz:
https://doaj.org/article/d816c55818324e859f94202ecdaad41c
Autor:
Jamie J. L. Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, George S. Baillie, Fred Schaper, Paul F. Pilch, Timothy M. Palmer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytoki
Externí odkaz:
https://doaj.org/article/150955b131d248018bd4158e8688ea0e
Publikováno v:
PLoS Biology, Vol 9, Iss 2, p e1000591 (2011)
How do mostly disordered proteins coordinate the specific assembly of very large signal transduction protein complexes? A newly emerging hypothesis may provide some clues towards a molecular mechanism.
Externí odkaz:
https://doaj.org/article/8b98bf34c6d345b39e4286426587b0cd
Autor:
Nadine Köhler, Nicole Wundrack, Svenja Schulz, Florian Bartonitz, Fred Schaper, Anna Dittrich
Publikováno v:
The FEBS Journal. 290:1765-1781
The transcription factor STAT3 is a potent activator of transcription, but evidence exists that STAT3 can also repress gene expression. However, little is known about the molecular mechanisms involved in STAT3-dependent gene repression. Notably, STAT
Autor:
Viktor Maurer, Ajmal Zarinwall, Zunhao Wang, Stefan Wundrack, Nicole Wundrack, Didem Ag Seleci, Vivien Helm, Daniil Otenko, Claudia Frank, Fred Schaper, Rainer Stosch, Georg Garnweitner
Publikováno v:
Sensors & Diagnostics. 1:469-484
Encapsulation of iron oxide and gold nanoparticles into the bilayer structure of transferrin-modified niosomes enables greatly enhanced and contamination-free SERS-signals in vitro as well as a dual-targeting functionality towards cancer cells.
Publikováno v:
Journal of Neurochemistry. 157:532-549
Interleukin-6 (IL-6) is a cytokine primarily known for immune regulation. There is also growing evidence that IL-6 triggers neurogenesis and impacts neural development, both life-long occurring processes that can be impaired by early-life and adult s