Longitudinal serum protein analysis of women with a high risk of developing breast cancer reveals large interpatient versus small intrapatient variations

Autor: Sophie Hagenaars, Lennard Dekker, Bob Ravesteijn, Ronald van Vlierberghe, Fred Romijn, Linda Verhoeff, Arjen Witkamp, Karin Schenk, Kristien Keymeulen, Marian Menke-Pluijmers, Anneriet Dassen, Birgitta Kortmann, Jakob de Vries, Emiel Rutgers, Yuri van der Burgt, Elma Meershoek-Klein Kranenbarg, Christa Cobbaert, Theo Luider, Wilma Mesker, Rob Tollenaar

Publikováno v: International Journal of Molecular Sciences, 23(20):12399. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12399
International Journal of Molecular Sciences, 23(20):12399. MDPI AG
International Journal of Molecular Sciences, 23(20). MDPI

The prospective, multicenter TESTBREAST study was initiated with the aim of identifying a novel panel of blood-based protein biomarkers to enable early breast cancer detection for moderate-to-high-risk women. Serum samples were collected every (half)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19e83269c8b7827518dcb0ddd6cb947
https://hdl.handle.net/1887/3564252

Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation

Autor: Rj, Berckmans, Nieuwland R, An, Böing, Fred Romijn, Ce, Hack, Sturk A

Publikováno v: Europe PubMed Central

We determined the numbers, cellular origin and thrombin-generating properties of microparticles in healthy individuals (n = 15). Microparticles, isolated from fresh blood samples and identified by flow cytometry, originated from platelets [237 x 10(6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::89e596202b985a7d2f4051c4349c441d
https://pubmed.ncbi.nlm.nih.gov/11341498

The amount of free corticosterone is increased during lipopolysaccharide-induced fever

Autor: Alejandro F. De Nicola, Ricardo Cabrera, E. Ron de Kloet, Fred Romijn, S. Mechiel Korte, Eef G.W.M. Lentjes, Eduard Schönbaum

Publikováno v: Life sciences. 66(7)

The relation between lipopolysaccharide (LPS)-induced fever and bioavailability of corticosterone (B) was examined in male Wistar rats. Animals were injected with LPS (2.5 mg/kg i.p.) or saline and core temperature and heart rate were monitored conti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc50069b18c31d3b40fda3d9df7f17e
https://pubmed.ncbi.nlm.nih.gov/10794511

Cellular origin and procoagulant properties of microparticles in meningococcal sepsis

Autor: Nieuwland R, Rj, Berckmans, McGregor S, An, Böing, Fred Romijn, Rg, Westendorp, Ce, Hack, Sturk A

Publikováno v: Europe PubMed Central

Patients with meningococcal sepsis generally suffer from disseminated intravascular coagulation (DIC). The aim of this study was to address whether these patients have elevated numbers of circulating microparticles that contribute to the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fae01a087240f13b92126fae11d10796
http://europepmc.org/abstract/med/10648405