Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Fred R. Frankel"'
Autor:
Fred R. Frankel, Dan H. Barouch, Erica N. Borducchi, Anna McNally, Nicholas M. Provine, Eung-Jun Im, Sufen Li
Publikováno v:
Journal of Virology. 87:4751-4755
A human immunodeficiency virus type 1 (HIV-1) vaccine that induces potent immune responses in the gastrointestinal mucosa would be highly desirable. Here we show that attenuated recombinant Listeria monocytogenes , administered orally utilizing its n
Autor:
Francis J. Novembre, Maria Kahn, Robert A. Rasmussen, John K. Yoon, Fred R. Frankel, Feng Yang, Welkin E. Johnson, Sandra J. Lee, Vijayakumar Velu, Janet DiPasquale, Francois Villinger, David C. Montefiori, Judy Lieberman, Shiu Lok Hu, Gaia Sciaranghella, Rama Rao Amara, Zhongxia Li, Girish Hemashettar, Sufen Li, Ruth M. Ruprecht, Nagadenahalli B. Siddappa, Samir K. Lakhashe, Marjorie Robert-Guroff
Publikováno v:
Vaccine. 29:5611-5622
a b s t r a c t We sought to induce primate immunodeficiency virus-specific cellular and neutralizing antibody (nAb) responses in rhesus macaques (RM) through a bimodal vaccine approach. RM were immunized intra- gastrically (i.g.) with the live-atten
Publikováno v:
The Journal of Immunology. 180:2504-2513
Most HIV infections result from heterosexual transmission to women. Because cellular immunity plays a key role in the control of the infection, we sought to strengthen cellular immune responses in vaginal tissue. We explored a novel prime-boost proto
Autor:
Elizabeth Strobert, Harold M. McClure, Shisong Jiang, Uma S. Babu, Katrina M. Nolan, Robert A. Rasmussen, Ruth M. Ruprecht, Fred R. Frankel, Kristina M. Williams, Judy Lieberman, Richard B. Raybourne
Publikováno v:
Vaccine. 25:7470-7479
Induction of strong cellular immunity will be important for AIDS vaccine candidates. Natural infection with wild-type Listeria monocytogenes (Lm), an orally transmitted organism, is known to generate strong cellular immunity, thus raising the possibi
Publikováno v:
Infection and Immunity. 73:5789-5798
Listeria monocytogenes is a bacterial pathogen that elicits a strong cellular immune response and thus has potential use as a vaccine vector. An attenuated strain, L. monocytogenes dal dat , produced by deletion of two genes ( dal and dat ) used for
Publikováno v:
Journal of Virology. 76:918-922
CD8+T cells are a major component of the adaptive response of a host to infections by viruses and other intracellular pathogenic agents. However, because of the intrinsic immaturity of the immune system of neonatal animals, neonates are highly sensit
Autor:
Fred R. Frankel, Marina Rayevskaya
Publikováno v:
Journal of Virology. 75:2786-2791
Vaccines designed to control chronic infections by intracellular agents such as human immunodeficiency virus type 1 (HIV-1) require the induction of cell-mediated immune responses to rid the host of pathogen-infected cells.Listeria monocytogeneshas c
Publikováno v:
The Journal of Immunology. 161:2985-2993
Using a strain of Listeria monocytogenes that stably expresses and secretes HIV gag to deliver this Ag to the MHC class I pathway of Ag processing, we have identified the immunodominant CTL epitope to gag in the BALB/c mouse and shown that it is Kd r
Publikováno v:
Infection and Immunity. 66:3552-3561
Listeria monocytogenes is an intracellular bacterial pathogen that elicits a strong cellular immune response following infection and therefore has potential use as a vaccine vector. However, while infections by L. monocytogenes are fairly rare and ca
Autor:
Francis J. Novembre, Fred R. Frankel, Vijayakumar Velu, Zhongxia Li, Samir K. Lakhashe, Chenghui Zhou, Nagadenahalli B. Siddappa, Mila Ayash-Rashkovsky, Rama Rao Amara, Sufen Li, Ruth M. Ruprecht, Saied Mirshahidi, Gaia Sciaranghella
Listeria monocytogenes (Lm) is known to induce strong cellular immune responses. We constructed a live-attenuated Lm vector, Lmdd-BdopSIVgag, which encodes SIVmac239 gag. Intragastric (i.g.) administration of 3 × 10(12) bacteria to rhesus macaques w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caace9d66f492a0d7a0705c1f744771a
https://europepmc.org/articles/PMC3039419/
https://europepmc.org/articles/PMC3039419/