Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Fred K Hagen"'
Autor:
Clayton A. Smith, Daniel A. Pollyea, Craig T. Jordan, Mohammad Minhajuddin, Kirk C. Hansen, Fred K. Hagen, Subhajyoti De, Jonathan A. Gutman, John M. Ashton, Vinod Kumar Yadav, Travis Nemkov, Shanshan Pei, Biniam Adane, Brett M. Stevens, Angelo D'Alessandro, Nabilah Khan, Peter A. Crooks
Publikováno v:
Journal of Biological Chemistry. 291:21984-22000
Although multidrug approaches to cancer therapy are common, few strategies are based on rigorous scientific principles. Rather, drug combinations are largely dictated by empirical or clinical parameters. In the present study we developed a strategy f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bc3a190990934d521b816ba453dff7
https://doi.org/10.1074/jbc.m116.750653
https://doi.org/10.1074/jbc.m116.750653
Autor:
Mathew C. Casimiro, Chenguang Wang, Jie Zhou, Anthony A. Sauve, Lifeng Tian, Sankar Addya, Ping Xu, Michael Gormley, Fred K. Hagen, Haiteng Deng, Michael J. Powell, Raymond E. Soccio, Richard G. Pestell
Publikováno v:
Oncotarget
// Lifeng Tian 1 , Chenguang Wang 1 , Fred K. Hagen 2 , Michael Gormley 1 , Sankar Addya 1 , Raymond Soccio 3 , Mathew C. Casimiro 1 , Jie Zhou 1 , Michael J. Powell 1 , Ping Xu 4 , Haiteng Deng 5 , Anthony A. Sauve 4 and Richard G. Pestell 1 1 Depar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48dcb34a49f5afaf531944e0cd9cdd0
https://doi.org/10.18632/oncotarget.2371
https://doi.org/10.18632/oncotarget.2371
Autor:
Chia-Hao Wu, Carla Beckham, Peng-Nien Yin, Jayme Olsen, Huei-Ju Ting, Fred K. Hagen, Yi-Fen Lee, Emelian Scosyrev, Edward M. Messing
Publikováno v:
Journal of Urology. 192:583-592
High grade bladder cancer is an extremely aggressive malignancy associated with high rates of morbidity and mortality. Understanding how exosomes may affect bladder cancer progression could reveal novel therapeutic targets.Exosomes derived from human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bee6bfb4ed2553e227135abc00350e
https://doi.org/10.1016/j.juro.2014.02.035
https://doi.org/10.1016/j.juro.2014.02.035
Publikováno v:
British Journal of Pharmacology. 171:2091-2098
Background and Purpose Cardiac ischaemia–reperfusion (IR) injury remains a significant clinical problem with limited treatment options available. We previously showed that cardioprotection against IR injury by nitro-fatty acids, such as nitro-linol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2091e4233dc61476c2d3d905699a14d8
https://doi.org/10.1111/bph.12405
https://doi.org/10.1111/bph.12405
Autor:
Mathew C. Casimiro, Er Chen, Anthony A. Sauve, Adam Ertel, Sankar Addya, Paolo Fortina, Michael J. Powell, Richard G. Pestell, Chenguang Wang, R Soccio, H Deng, Jie Zhou, Fred K. Hagen, Michael P. Lisanti, Zhijiu Zhong, P Xu, Michael Gormley, Lifeng Tian
Publikováno v:
Cancer Research. 73:P2-06
Peroxisome proliferator-activated receptorg (Pparγ) is a member of the nuclear receptor (NR) superfamily, which regulates diverse biological functions including lipogenesis and differentiation, anti-inflammation, insulin sensitivity, cellular prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450bc7cffa049b048343de0db86eb51d
https://doi.org/10.1158/0008-5472.sabcs13-p2-06-02
https://doi.org/10.1158/0008-5472.sabcs13-p2-06-02
Autor:
Patricia Greninger, Jane L. Liesveld, Kevin P. Callahan, Shanshan Pei, Jeffrey Settleman, Cyril H. Benes, Cheryl Corbett, John M. Ashton, Michael W. Becker, Fred K. Hagen, Peter A. Crooks, Haobin Ye, Mohammad Minhajuddin, Zheng Li, Eleni D. Lagadinou, Joshua Munger, Kristen M. O'Dwyer, Lei Shi, Sarah J. Neering, Craig T. Jordan, Marlene Balys
Publikováno v:
Journal of Biological Chemistry. 288:33542-33558
The development of strategies to eradicate primary human acute myelogenous leukemia (AML) cells is a major challenge to the leukemia research field. In particular, primitive leukemia cells, often termed leukemia stem cells, are typically refractory t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3e2ab293929403d191dda5f474f6f8
https://doi.org/10.1074/jbc.m113.511170
https://doi.org/10.1074/jbc.m113.511170
Autor:
Nicole Lerner-Marmarosh, Mahin D. Maines, Fred K. Hagen, Tihomir Miralem, Cicerone Tudor, Peter E. M. Gibbs
Publikováno v:
Journal of Biological Chemistry. 287:24698-24712
PKCδ, a Ser/Thr kinase, promotes cell growth, tumorigenesis, and apoptosis. Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase, inhibits apoptosis by reducing biliverdin-IX to antioxidant bilirubin. The enzymes are activated by similar stimuli.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0927d0ea12870debb4d079d0b8162bc
https://doi.org/10.1074/jbc.m111.326504
https://doi.org/10.1074/jbc.m111.326504
Autor:
Kira L. Santos, Fred K. Hagen, Robert C. Speth, Vardan T. Karamyan, Emanuel Escher, Michael Bader, Naomi J. Wangler, Ines Schadock
Publikováno v:
Journal of Biological Chemistry. 287:114-122
Recently, we discovered a novel non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site in rodent and human brain membranes, which is distinctly different from angiotensin receptors and key proteases processing angiotensins. It is hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1338b7780ee1cb6e645c16065328846e
https://doi.org/10.1074/jbc.m111.273052
https://doi.org/10.1074/jbc.m111.273052
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1515-1519
Melampomagnolide B has been identified as a new antileukemic sesquiterpene. A biotin-conjugated derivative of melampomagnolide B was designed and synthesized in order to elucidate its mechanism of action. A study of the biochemical interactions of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f5fe20765e94736a0b07c287ed2bdd
https://doi.org/10.1016/j.bmc.2010.12.045
https://doi.org/10.1016/j.bmc.2010.12.045
Autor:
Jennifer R. Hryhorenko, James E. Melvin, Kiran Ambatipudi, Stacy Gregoire, Claire M. Delahunty, Fred K. Hagen, John R. Yates, Rubina Shafi, Robert E. Marquis, Hyun Koo, Xuemei Han
Publikováno v:
Journal of Proteome Research. 9:6605-6614
The saliva proteome includes host defense factors and specific bacterial-binding proteins that modulate microbial growth and colonization of the tooth surface in the oral cavity. A multidimensional mass spectrometry approach identified the major host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387a08f6d49a699389b1534c4b381450
https://doi.org/10.1021/pr100786y
https://doi.org/10.1021/pr100786y