Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Fred J Hendler"'
Publikováno v:
Ethics & Human Research
With the rapid spread of SARS‐CoV2 has come a rapid proliferation of clinical research studies, resulting in considerable strain on research ethics committees (RECS), which need to review study proposals. RECs are pressured to move through the revi
Publikováno v:
International Journal of Cancer. 82:377-384
We established a new syngeneic murine model of oral squamous-cell carcinoma (SCC) to analyze the potential role of immune recognition determinants in the early development of oral cancer. In this study, we examined whether SCC that undergo transforma
Publikováno v:
Cancer Control. 6:1-5
Publikováno v:
Oncogene. 15:1161-1170
Our previous reports have shown that two thirds of 4-nitroquinoline-1-oxide (4NQO)-induced murine oral squamous cell carcinomas (SCC) have Hras1 mutations. Loss of heterozygosity (LOH) involving the distal portion of chromosome (Chr) 7 occurred in ha
Publikováno v:
Molecular Carcinogenesis. 19:8-16
We have previously shown that all CBA/J mice exposed to 4-nitroquinoline-1-oxide (4NQO) eventually develop oral cavity squamous cell carcinomas, and two-thirds of these tumors have Ha-ras-1 (Hras1) point mutations at codon 12. Half of the tumors with
Publikováno v:
Genomics. 38:58-71
Although occasional DNA polymorphisms have been observed in inbred mice, CBA/J and C3H/HeN mice have two microsatellite alleles at over 1/3 of microsatellite loci tested. Since DNA polymorphisms were not detected in DBA/2J, C57BL/6J, and BALB/cJ, the
Autor:
Michael Leonberger, Brian L. Hawkins, Douglas M. Ackermann, Serge A. Martinez, Briana W. Heniford, Fred J. Hendler
Publikováno v:
Head & Neck. 16:424-432
Background. A murine model of oral cavity carcinogenesis is needed to study the molecular aspects of malignant transformation. 4-Nitroquinoline-1-oxide (4NQO), a water-soluble carcinogen, produces squamous cell carcinoma in rodents. Protocols were de
Autor:
Carter Van Waes, Lyon L. Gleich, Jian Dong, Robert J. Bohinski, Ya-Qin Li, Fred J. Hendler, Peter J. Stambrook
Publikováno v:
Cancer gene therapy. 10(2)
The Flt3 ligand (Flt3-L) manifests antitumor activity, presumably due to its capacity to recruit dendritic cells and cause their proliferation. To assess whether local production of Flt3-L can mediate a "distant bystander" effect, murine B4B8 squamou
Publikováno v:
Otolaryngology–Head and Neck Surgery. 117
Autor:
Fred J. Hendler
Publikováno v:
The American Journal of the Medical Sciences. 293:332-347
Benign breast disease affects almost all women, although only one out of 11 will eventually develop breast cancer. Fibrocystic disease or benign breast mastopathies have been associated with an increased propensity to progress to malignancy. However,