Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Fred Hess"'
Autor:
Nicholas B. Hastings, Xiaohai Wang, Lixin Song, Brent D. Butts, Diane Grotz, Richard Hargreaves, J. Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X. Lu, Maureen Maguire, Veeravan Mahadomrongkul, Ernest J. McEachern, Xuesong Ouyang, Thomas W. Rosahl, Harold Selnick, Michaela Stanton, Giuseppe Terracina, David J. Vocadlo, Ganfeng Wang, Joseph L. Duffy, Eric M. Parker, Lili Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-16 (2017)
Abstract Background Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post-translational modifi
Externí odkaz:
https://doaj.org/article/1ce645702743455b9fc3c2ca7c604062
Autor:
Xiaohai Wang, Karen Smith, Michelle Pearson, Anna Hughes, Mali L Cosden, Jacob Marcus, J Fred Hess, Mary J Savage, Thomas Rosahl, Sean M Smith, Joel B Schachter, Jason M Uslaner
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195486 (2018)
Although tau pathology, behavioral deficits, and neuronal loss are observed in patients with tauopathies, the relationship between these endpoints has not been clearly established. Here we found that rTg4510 mice, which overexpress human mutant tau i
Externí odkaz:
https://doaj.org/article/673ecce02d2142e3bebd0ef7ac288791
Publikováno v:
Current sports medicine reports. 21(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea0aa8d4de633a15f05fb799d03185e
https://pubmed.ncbi.nlm.nih.gov/36342392
https://pubmed.ncbi.nlm.nih.gov/36342392
Autor:
Giuseppe Terracina, Jerry P. Melchor, Cyrille Sur, David Kinsley, Lynn A. Hyde, Harold G. Selnick, Joseph L. Duffy, Jacob Marcus, Lili Zhang, Xiangjun Meng, Michelle Pearson, Xiaohai Wang, J. Fred Hess, David J. Vocadlo, Kwok-Lam Karen Hong, Julie Lee, Jason M. Uslaner, Daniel Rubins, Sherry X. Lu, Ernest J. McEachern, Sean M. Smith, Karen M. Smith, Wenping Li, Joel B. Schachter, Shu-Cheng Chen, Lixin Song, Eric D. Hostetler
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:252-263
Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic of Alzheimer disease and other tauopathies. Tau is subject to O-linked N-acetylglucosamine (O-GlcNAc) modification, and O-GlcNAcylation of ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61e5e35f9eabaa1beed69c18d740ed47
https://doi.org/10.1124/jpet.120.266122
https://doi.org/10.1124/jpet.120.266122
Publikováno v:
Pediatric Surgery ISBN: 9783030965419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a40704319ac1196ad5b6de1db9a27c9
https://doi.org/10.1007/978-3-030-96542-6_85
https://doi.org/10.1007/978-3-030-96542-6_85
Autor:
Xiaohai, Wang, Wenping, Li, Jacob, Marcus, Michelle, Pearson, Lixin, Song, Karen, Smith, Giuseppe, Terracina, Julie, Lee, Kwok-Lam Karen, Hong, Sherry X, Lu, Lynn, Hyde, Shu-Cheng, Chen, David, Kinsley, Jerry P, Melchor, Daniel J, Rubins, Xiangjun, Meng, Eric, Hostetler, Cyrille, Sur, Lili, Zhang, Joel B, Schachter, J Fred, Hess, Harold G, Selnick, David J, Vocadlo, Ernest J, McEachern, Jason M, Uslaner, Joseph L, Duffy, Sean M, Smith
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(2)
Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic of Alzheimer disease and other tauopathies. Tau is subject to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44f1a098def747a0930b97c58e7f1fb3
https://pubmed.ncbi.nlm.nih.gov/32493725
https://pubmed.ncbi.nlm.nih.gov/32493725
Autor:
J. Fred Hess, Ramesh Kaul, Jacob Marcus, Jeanine E. Ballard, Joseph L. Duffy, Yongbao Zhu, Xiaohai Wang, Mary J. Savage, Changwei Mu, Kun Liu, Chang Bai, Daniel J. Klein, Harold G. Selnick, Yuanxi Zhou, Cuyue Tang, Yaode Wang, David J. Vocadlo, Michelle Pearson, Tong-Shuang Li, Ernest J. McEachern, Joel B. Schachter, Wei Zhongyong
Publikováno v:
Journal of medicinal chemistry. 62(22)
Inhibition of O-GlcNAcase (OGA) has emerged as a promising therapeutic approach to treat tau pathology in neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. Beginning with carbohydrate-based lead molecules, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d54bdde74626eaae039e9699c354cc
https://pubmed.ncbi.nlm.nih.gov/31668062
https://pubmed.ncbi.nlm.nih.gov/31668062
Autor:
Patricia Miller, Yaode Wang, Joseph Della Rocca, Jeffrey L. Evelhoch, Paul J. Coleman, Kerry Riffel, Zhizhen Zeng, Elizabeth Joshi, Kun Yang, Xiaoping Zhang, Kerim Babaoglu, Eric D. Hostetler, Talakad G. Lohith, Stacey O'Malley, David Hesk, Abbas Walji, Jaume Balsells, Mona Purcell, Jing Li, Serena Xu, Brett Connolly, Stacey Melquist, Arie Struyk, Jianmin Fu, Julie A. O'Brien, Marie A. Holahan, Harold G. Selnick, Fred Hess, Aimie Ogawa, David J. Schenk, Idriss Bennacef, Cristian Salinas, Joel B. Schachter, Aileen Soriano, Liza Gantert
Publikováno v:
Journal of Medicinal Chemistry. 59:4778-4789
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. In vivo detection of NFTs using PET imaging represents a unique oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39b60a8ba41ad44ebe7487bf9b6714d
https://doi.org/10.1021/acs.jmedchem.6b00166
https://doi.org/10.1021/acs.jmedchem.6b00166
Autor:
J. Fred Hess, Anna Hughes, Jason M. Uslaner, Sean M. Smith, Joel B. Schachter, Xiaohai Wang, Jacob N. Marcus, Karen Smith, Mali Cosden, Thomas W. Rosahl, Mary J. Savage, Michelle Pearson
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195486 (2018)
PLoS ONE
PLoS ONE
Although tau pathology, behavioral deficits, and neuronal loss are observed in patients with tauopathies, the relationship between these endpoints has not been clearly established. Here we found that rTg4510 mice, which overexpress human mutant tau i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87226bfbd25427a07d31e4903c689596
http://europepmc.org/articles/PMC5889169?pdf=render
http://europepmc.org/articles/PMC5889169?pdf=render
Autor:
Munish C. Gupta, Kenneth J. Paonessa, W. Fred Hess, Michael Faloon, Oheneba Boachie-Adjei, Elias C. Papadopoulos, Christina Sacramento, Ferran Pellisé, Francisco Javier Sánchez Pérez-Grueso, Han Jo Kim, Matthew E. Cunningham, Baron S. Lonner, Michael J. Mendelow, Muharrem Yazici
Publikováno v:
The Spine Journal. 15:983-991
Background context Hyperkyphosis confers a significant risk for neurologic deterioration as well as compromised cardiopulmonary function. Posterior vertebral column resection (PVCR) is a challenging but effective technique for spinal cord decompressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36373508c9cf6f14b1e479a1ae881e6a
https://doi.org/10.1016/j.spinee.2013.03.023
https://doi.org/10.1016/j.spinee.2013.03.023