Zobrazeno 1 - 10
of 1 011
pro vyhledávání: '"Fred H Gage"'
Autor:
Jeanne F Nichols, Ryan Moran, Howard J Phang, Stephanie R Heimler, Lina M Scandalis, David Wing, Daniel Moreno, Gerald S Shadel, Fred H Gage, Anthony J A Molina
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction While it is well recognised that aging is a heterogeneous process, our understanding of the determinants of biological aging and its heterogeneity remains unclear. The San Diego Nathan Shock Center (SD-NSC) Clinical Cohort aims to establ
Externí odkaz:
https://doaj.org/article/7d8cd9a0abba4c6285340ff8ff1a52db
Autor:
Stephen Johnston, Sarah L Parylak, Stacy Kim, Nolan Mac, Christina Lim, Iryna Gallina, Cooper Bloyd, Alexander Newberry, Christian D Saavedra, Ondrej Novak, J Tiago Gonçalves, Fred H Gage, Matthew Shtrahman
Publikováno v:
eLife, Vol 10 (2021)
Recombinant adeno-associated virus (rAAV) has been widely used as a viral vector across mammalian biology and has been shown to be safe and effective in human gene therapy. We demonstrate that neural progenitor cells (NPCs) and immature dentate granu
Externí odkaz:
https://doaj.org/article/d6ed94cb81614f08ad343b6ed27bc2a8
Autor:
Joseph Herdy, Simon Schafer, Yongsung Kim, Zoya Ansari, Dina Zangwill, Manching Ku, Apua Paquola, Hyungjun Lee, Jerome Mertens, Fred H Gage
Publikováno v:
eLife, Vol 8 (2019)
Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages. Although iN technology has an enormous potential for modeling age-related dis
Externí odkaz:
https://doaj.org/article/3e403c8aedd14108b8fe7d58a335b439
Autor:
Maria C Marchetto, Branka Hrvoj-Mihic, Bilal E Kerman, Diana X Yu, Krishna C Vadodaria, Sara B Linker, Iñigo Narvaiza, Renata Santos, Ahmet M Denli, Ana PD Mendes, Ruth Oefner, Jonathan Cook, Lauren McHenry, Jaeson M Grasmick, Kelly Heard, Callie Fredlender, Lynne Randolph-Moore, Rijul Kshirsagar, Rea Xenitopoulos, Grace Chou, Nasun Hah, Alysson R Muotri, Krishnan Padmanabhan, Katerina Semendeferi, Fred H Gage
Publikováno v:
eLife, Vol 8 (2019)
Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate importa
Externí odkaz:
https://doaj.org/article/8eb5b01f74684625be3abe311de8e7dd
Autor:
Xinde Zheng, Leah Boyer, Mingji Jin, Jerome Mertens, Yongsung Kim, Li Ma, Michael Hamm, Fred H Gage, Tony Hunter
Publikováno v:
eLife, Vol 5 (2016)
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the tr
Externí odkaz:
https://doaj.org/article/221dfd8b30b24e6cb42a4ace07578e2c
Autor:
Xinde Zheng, Leah Boyer, Mingji Jin, Yongsung Kim, Weiwei Fan, Cedric Bardy, Travis Berggren, Ronald M Evans, Fred H Gage, Tony Hunter
Publikováno v:
eLife, Vol 5 (2016)
mTOR inhibition is beneficial in neurodegenerative disease models and its effects are often attributable to the modulation of autophagy and anti-apoptosis. Here, we report a neglected but important bioenergetic effect of mTOR inhibition in neurons. m
Externí odkaz:
https://doaj.org/article/33701fc01b264587a4c9be099cc54e22
Autor:
Gene W Yeo, Xiangdong Xu, Tiffany Y Liang, Alysson R Muotri, Christian T Carson, Nicole G Coufal, Fred H Gage
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 10, Pp 1951-1967 (2007)
Human embryonic stem cells (hESCs) and neural progenitor (NP) cells are excellent models for recapitulating early neuronal development in vitro, and are key to establishing strategies for the treatment of degenerative disorders. While much effort had
Externí odkaz:
https://doaj.org/article/24b182a2e8a24c499670e239a31ce42c
Publikováno v:
eLife, Vol 4 (2015)
NMDA receptor (NMDAR)-dependent forms of synaptic plasticity are thought to underlie the assembly of developing neuronal circuits and to play a crucial role in learning and memory. It remains unclear how NMDAR might contribute to the wiring of adult-
Externí odkaz:
https://doaj.org/article/84ab518fc05149c6bf17ad4e79a60b2f
Autor:
Wei eDeng, Fred H Gage
Publikováno v:
Frontiers in Systems Neuroscience, Vol 9 (2015)
The neurogenesis hypothesis of depression is based on the correlation between the rate of adult hippocampal neurogenesis and the affective status of rodents. However, studies investigating the role of neurogenesis in the causation of mood regulation
Externí odkaz:
https://doaj.org/article/2d821ad9c277480cb9fb447b4d752f3e
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
While it has been hypothesized that adult neurogenesis plays a role in the encoding of temporal information at long time scales, the temporal relationship of immature cells to the highly rhythmic network activity of the hippocampus has been largely u
Externí odkaz:
https://doaj.org/article/a0d3efe0b5a84121b9e4fb6cee55ee4f