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Autor:
Pin-Fang Lin, Qi Guo, Carol Deminie, Brian Terry, Fred Djang, Brett S. Robinson, Richard J. Colonno, Yi-Fei Gong, David A. Stock, Keith Riccardi, Wade S. Blair
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:2093-2099
BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC50) of 2.6 to 5.3 nM and an EC90of 9 to 15 nM in cell culture. Proof-of-prin