Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Fred De Winter"'
Autor:
Isaac Francos-Quijorna, Marina Sánchez-Petidier, Emily R. Burnside, Smaranda R. Badea, Abel Torres-Espin, Lucy Marshall, Fred de Winter, Joost Verhaagen, Victoria Moreno-Manzano, Elizabeth J. Bradbury
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Inflammation resolution failure is a pathological hallmark of spinal cord injury. Here, the authors show in rodents that chondroitin sulfate proteoglycans contribute to failed resolution by preventing immune cells at the injury core from converting t
Externí odkaz:
https://doaj.org/article/1fa069c153554f5aa4e6bb33426afeed
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation. Interestingl
Externí odkaz:
https://doaj.org/article/f9cbba535eca437cb6466f767f5796d0
Autor:
Arie C van Vliet, Jinhui Lee, Marlijn van der Poel, Matthew R J Mason, Jasprina N Noordermeer, Lee G Fradkin, Martijn R Tannemaat, Martijn J A Malessy, Joost Verhaagen, Fred De Winter
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249748 (2021)
A human neuroma-in continuity (NIC), formed following a peripheral nerve lesion, impedes functional recovery. The molecular mechanisms that underlie the formation of a NIC are poorly understood. Here we show that the expression of multiple genes of t
Externí odkaz:
https://doaj.org/article/c7133a97562842fe8a06a7b4001c0c4e
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
A spinal root avulsion is the most severe proximal peripheral nerve lesion possible. Avulsion of ventral root filaments disconnects spinal motoneurons from their target muscles, resulting in complete paralysis. In patients that undergo brachial plexu
Externí odkaz:
https://doaj.org/article/2cf52272938f4dd3b280a6164cc148c4
Autor:
Jelmer Willems, Arthur P H de Jong, Nicky Scheefhals, Eline Mertens, Lisa A E Catsburg, Rogier B Poorthuis, Fred de Winter, Joost Verhaagen, Frank J Meye, Harold D MacGillavry
Publikováno v:
PLoS Biology, Vol 18, Iss 4, p e3000665 (2020)
The correct subcellular distribution of proteins establishes the complex morphology and function of neurons. Fluorescence microscopy techniques are invaluable to investigate subcellular protein distribution, but they suffer from the limited ability t
Externí odkaz:
https://doaj.org/article/3f6aae25fa144ec6809509e7803446db
Autor:
Thomas W Gould, Bertha Dominguez, Fred de Winter, Gene W Yeo, Patrick Liu, Balaji Sundararaman, Thomas Stark, Anthony Vu, Jay L Degen, Weichun Lin, Kuo-Fen Lee
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1007948 (2019)
Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that neural activity-regulated ne
Externí odkaz:
https://doaj.org/article/21da27eafb4345da988a4e6b546ea84c
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170314 (2017)
Terminal Schwann cells (TSCs) are specialized cells that envelop the motor nerve terminal, and play a role in the maintenance and regeneration of neuromuscular junctions (NMJs). The chemorepulsive protein semaphorin 3A (SEMA3A) is selectively up-regu
Externí odkaz:
https://doaj.org/article/1c991427353248f2b55c210ef3ac9af6
Autor:
Ruben Eggers, Fred de Winter, Stefan A Hoyng, Kasper C D Roet, Erich M Ehlert, Martijn J A Malessy, Joost Verhaagen, Martijn R Tannemaat
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71076 (2013)
Although the peripheral nerve is capable of regeneration, only a small minority of patients regain normal function after surgical reconstruction of a major peripheral nerve lesion, resulting in a severe and lasting negative impact on the quality of l
Externí odkaz:
https://doaj.org/article/c730a81bf45b4789b745b5224acc8050
Autor:
Eleni Sinopoulou, Aline Barroso Spejo, Naomi Roopnarine, Emily R. Burnside, Katalin Bartus, Fred De Winter, Stephen B. McMahon, Elizabeth J. Bradbury
Publikováno v:
Journal of Neuroscience Research, 100, 2055-2076. Wiley-Liss Inc.
Cervical level spinal cord injury (SCI) can severely impact upper limb muscle function, which is typically assessed in the clinic using electromyography (EMG). Here, we established novel preclinical methodology for EMG assessments of muscle function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e877cb9846a5f6dee2a799a39887031a
https://doi.org/10.1002/jnr.25111
https://doi.org/10.1002/jnr.25111
Autor:
Katerina Stepankova, Barbora Smejkalova, Lucia Machova-Urdzikova, Katerina Haveliková, Joost Verhaagen, Fred de Winter, Vit Herynek, Jessica Kwok, James Fawcett, Pavla Jendelova
Sensory axons cut within the spinal cord do not regenerate spontaneously. This failure is due in part to absence of an appropriate adhesion molecule on sensory axons, able to interact with the CNS environment. Previous work has shown that transductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd2574aac6a5d8ce7cd4cb25008f8bf
https://doi.org/10.1101/2023.03.24.534172
https://doi.org/10.1101/2023.03.24.534172
