Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Fred D. Mast"'
Autor:
Natasha M. Bourgeois, Ling Wei, Nhi N. T. Ho, Maxwell L. Neal, Denali Seferos, Tinotenda Tongogara, Fred D. Mast, John D. Aitchison, Alexis Kaushansky
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionDengue is an arboviral disease causing severe illness in over 500,000 people each year. Currently, there is no way to constrain dengue in the clinic. Host kinase regulators of dengue virus (DENV) infection have the potential to be disrupt
Externí odkaz:
https://doaj.org/article/df199684a6b74f57a0f955ed2a41a8e2
Autor:
Christoph C. Carter, Fred D. Mast, Jean Paul Olivier, Natasha M. Bourgeois, Alexis Kaushansky, John D. Aitchison
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The mechanistic target of rapamycin (mTOR) functions in two distinct complexes: mTORC1, and mTORC2. mTORC1 has been implicated in the pathogenesis of flaviviruses including dengue, where it contributes to the establishment of a pro-viral autophagic s
Externí odkaz:
https://doaj.org/article/5002ed19d7d2420d940c0b5de71b1ad0
Autor:
Whitney E. Harrington, Winnie Yeung, Ingrid A. Beck, Fred D. Mast, John Houck, Sheila Styrchak, Leslie R. Miller, Song Li, Micaela Haglund, Yonghou Jiang, Blair Armistead, Jackson Wallner, Tina Nguyen, Daisy Ko, Samantha Hardy, Alyssa Oldroyd, Ana Gervassi, John D. Aitchison, Lisa M. Frenkel
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Background Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear. Methods To identify SARS-CoV
Externí odkaz:
https://doaj.org/article/eef1ebf3b2da434aa54c155bced8b70e
Autor:
Kamalakannan Vijayan, Igor Cestari, Fred D. Mast, Elizabeth K.K. Glennon, Suzanne M. McDermott, Heather S. Kain, Alyssa M. Brokaw, John D. Aitchison, Kenneth Stuart, Alexis Kaushansky
Publikováno v:
iScience, Vol 21, Iss , Pp 603-611 (2019)
Summary: The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome-
Externí odkaz:
https://doaj.org/article/71883b55b11447df94c7c0940ad75586
Autor:
Yonghou Jiang, Fergal Duffy, Jennifer Hadlock, Andrew Raappana, Sheila Styrchak, Ingrid Beck, Fred D. Mast, Leslie R. Miller, William Chour, John Houck, Blair Armistead, Venkata R. Duvvuri, Winnie Yeung, Micaela Haglund, Jackson Wallner, Julie A. Wallick, Samantha Hardy, Alyssa Oldroyd, Daisy Ko, Ana Gervassi, Kim M. Murray, Henry Kaplan, John D. Aitchison, James R. Heath, D. Noah Sather, Jason D. Goldman, Lisa Frenkel, Whitney E. Harrington
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Background Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor
Externí odkaz:
https://doaj.org/article/cd573774925a43b6bf26a92fa1b1734f
Autor:
Thurston Herricks, David J. Dilworth, Fred D. Mast, Song Li, Jennifer J. Smith, Alexander V. Ratushny, John D. Aitchison
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 1, Pp 279-288 (2017)
Cell growth is a complex phenotype widely used in systems biology to gauge the impact of genetic and environmental perturbations. Due to the magnitude of genome-wide studies, resolution is often sacrificed in favor of throughput, creating a demand fo
Externí odkaz:
https://doaj.org/article/e7ee2b039d5944b59fb1f58ade53490e
Autor:
Elizabeth K.K. Glennon, Laura S. Austin, Nadia Arang, Heather S. Kain, Fred D. Mast, Kamalakannan Vijayan, John D. Aitchison, Stefan H.I. Kappe, Alexis Kaushansky
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3391-3399.e4 (2019)
Summary: Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding
Externí odkaz:
https://doaj.org/article/26839600807547f498e38d3107d86864
Autor:
Fred D. Mast, Jing Li, Maninder K. Virk, Sarah C. Hughes, Andrew J. Simmonds, Richard A. Rachubinski
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 5, Pp 659-672 (2011)
SUMMARY Human peroxisome biogenesis disorders are lethal genetic diseases in which abnormal peroxisome assembly compromises overall peroxisome and cellular function. Peroxisomes are ubiquitous membrane-bound organelles involved in several important b
Externí odkaz:
https://doaj.org/article/d60d6a8cc5a246eabfcad5fa41e3b4de
Autor:
Jean Paul Olivier, Maxwell Lewis Neal, John D. Aitchison, Alexis Kaushansky, Jasmin Coulombe-Huntington, Thierry Bertomeu, Carpp Ln, Mike Tyers, Fred D. Mast, Arti T. Navare
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
article-version (status) pre
article-version (number) 2
Viruses co-opt host proteins to carry out their lifecycle. Repurposed host proteins may thus become functionally compromised; a situation analogous to a loss-of-function mutation. We term such host proteins viral-induced hypomorphs. Cells bearing can
Autor:
Sanjeev Kumar, Maxwell L. Neal, Song Li, Arti T. Navare, Fred D. Mast, Michael P. Rout, John D. Aitchison
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene expression. The inner ring nucleoporin Nup170 has been implicated in chromatin organization and the maintenance of gene silencing in subtelomeric regions. To gain i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13c017aa72e3370809bb3df66996ff7a
https://doi.org/10.1101/2022.06.17.496627
https://doi.org/10.1101/2022.06.17.496627