Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Fred D. Lott"'
Autor:
Yuhua Yang, Adam Davenport, Michael G. Kelly, Andrew Tasker, Michael Croghan, Guomin Yao, Fred D. Lott, Jeff D. Reagan, Christopher H. Fotsch, James Davis, Minghan Wang, Chiara Ghiron, Steve F. Poon, Qingping Zeng, David Martin, Elena Portero-Larragueta, Thomas Stephen Coulter, David J. St. Jean, Jonathan Hutchinson, Charles Henley, Kelly Regal, Paul E. Harrington, Sean Morony, Jeffrey Clarine, Jenny Ying-Lin Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5544-5547
The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e863f669015b2935d346cb0793aca12e
https://doi.org/10.1016/j.bmcl.2010.07.060
https://doi.org/10.1016/j.bmcl.2010.07.060
Autor:
Betsy Daugherty, Caroline Bishop, Chen Dong, Yongliang Zhang, Paige Holst, Ning Sun, Fred D. Lott, Yeonseok Chung, Andrew A. Welcher, Carole Kurahara, Hilary T. Chute
Publikováno v:
Proceedings of the National Academy of Sciences. 103:11695-11700
T cell activation and tolerance are regulated by costimulatory molecules. Although PD-1 serves as a crucial negative regulator of T cells, the function of its ligands, PDL1 and PDL2, is still controversial. In this study, we created a PDL2-deficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c51556f92c44957f51e1b2781eb91d
https://doi.org/10.1073/pnas.0601347103
https://doi.org/10.1073/pnas.0601347103
Publikováno v:
Journal of Thrombosis and Thrombolysis. 5:15-23
Recombinant human megakaryocyte growth and development factor (rHuMGDF) is a c-mpl ligand that promotes the differentiation of CD34+ precursor cells into megakaryocyte, and then platelets. In experimental animals, injection of this and other c-mpl li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c8a4b57279a11711ae330a58dac006
https://doi.org/10.1023/a:1008811813115
https://doi.org/10.1023/a:1008811813115
Publikováno v:
Pharmaceutical Research. 11:1101-1109
Two powder formulations (MMAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::519a99294318c7a57b568ad76ddcd7bf
https://doi.org/10.1023/a:1018924512928
https://doi.org/10.1023/a:1018924512928
Publikováno v:
International Journal of Pharmaceutics. 101:81-87
An in vitro system-was developed to better emulate particle deposition in the respiratory tract. Inhalers were connected to a glass throat (BP 1988 Appendix XVII C) or to a silicone throat that exactly duplicated the surface geometry of the oral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::513f34d7de0d314a22a29bcd069a93a9
https://doi.org/10.1016/0378-5173(94)90078-7
https://doi.org/10.1016/0378-5173(94)90078-7
Publikováno v:
Pharmaceutical Research. 10:1604-1610
Recombinant methionyl human granulocyte colony stimulating factor (G-CSF), a molecule of 18.8 kDa, has been shown to induce a systemic response after delivery by aerosol. In this work, rate and extent of absorption as well as the response were determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60705aab445e859e219ebdc2d4cae95a
https://doi.org/10.1023/a:1018920619424
https://doi.org/10.1023/a:1018920619424
Autor:
Yuhua Yang, Steve F. Poon, Jeff D. Reagan, David J. St. Jean, Fred D. Lott, Charles Henley, Jenny Ying-Lin Lu, James Davis, Paul E. Harrington, Christopher H. Fotsch, Sean Morony
Publikováno v:
Journal of medicinal chemistry. 52(21)
Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9f6898ca381a10c9ccf357ab442ca9
https://pubmed.ncbi.nlm.nih.gov/19835382
https://pubmed.ncbi.nlm.nih.gov/19835382
Autor:
Ann Stiko, Fred D. Lott, Duke Virca, Kelly R. Pitts, Christopher F. Toombs, Bernard Buetow, Ping Guo
Publikováno v:
Journal of pharmacological and toxicological methods. 55(2)
Introduction Methods to determine infarct size following ischemia-reperfusion injury include gross staining with triphenyltetrazolium chloride (TTC) and perfusion of colored dyes to demarcate the non-ischemic zone. Infarcted tissue (INF) can typicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169d80664ba74a0fdc0e7ae4727224f6
https://pubmed.ncbi.nlm.nih.gov/16931060
https://pubmed.ncbi.nlm.nih.gov/16931060
Publikováno v:
Pharmacology. 52(2)
Ischemic preconditioning (PC) has been consistently observed to reduce infarct size in models of regional myocardial ischemia. However, it is also known to render the heart resistant to injury for only a finite period of time (2 h). Myocardial adenos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457a010e5ef5e3c0201a20d94adf1aa3
https://pubmed.ncbi.nlm.nih.gov/8851632
https://pubmed.ncbi.nlm.nih.gov/8851632