Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Fred Brewer"'
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2442
Isothermal titration microcalorimetry (ITC) can directly determine the thermodynamic binding parameters of biological molecules including affinity constant, binding stoichiometry, heat of binding (enthalpy) and indirectly the entropy, and free energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4e70429cc1d1ffe0ac15ab681ba4706
https://pubmed.ncbi.nlm.nih.gov/35320526
https://pubmed.ncbi.nlm.nih.gov/35320526
Publikováno v:
Methods in Molecular Biology ISBN: 9781071620540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9227ed1b7eacbd8fded3d39295b2d40a
https://doi.org/10.1007/978-1-0716-2055-7_10
https://doi.org/10.1007/978-1-0716-2055-7_10
Publikováno v:
Comprehensive Glycoscience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5cd86437abbc1111a0ba9a88a2ff50
https://doi.org/10.1016/b978-0-12-819475-1.00054-7
https://doi.org/10.1016/b978-0-12-819475-1.00054-7
Publikováno v:
Glycobiology
Sletmoen, M, Gerken, T A, Stokke, B T, Burchell, J & Brewer, C F 2018, ' Tn and STn are members of a family of carbohydrate tumour antigens that possess carbohydrate-carbohydrate interactions ', Glycobiology, vol. 28, no. 7, cwy032, pp. 437–442 . https://doi.org/10.1093/glycob/cwy032
Sletmoen, M, Gerken, T A, Stokke, B T, Burchell, J & Brewer, C F 2018, ' Tn and STn are members of a family of carbohydrate tumour antigens that possess carbohydrate-carbohydrate interactions ', Glycobiology, vol. 28, no. 7, cwy032, pp. 437–442 . https://doi.org/10.1093/glycob/cwy032
The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ac1dc1d9ba6a45529816c661b13923
https://doi.org/10.1093/glycob/cwy032
https://doi.org/10.1093/glycob/cwy032
Autor:
Fred Brewer, C.
Publikováno v:
In Advances in Carbohydrate Chemistry and Biochemistry 2004 59:0-7
Publikováno v:
Glycobiology. 25:524-534
Mucins are linear, heavily O-glycosylated proteins with physiological roles that include cell signaling, cell adhesion, inflammation, immune response and tumorgenesis. Cancer-associated mucins often differ from normal mucins by presenting truncated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4403b49c6a376395494eb2085d0c0db0
https://doi.org/10.1093/glycob/cwu183
https://doi.org/10.1093/glycob/cwu183
Autor:
C. Fred Brewer, James W. Dennis
Publikováno v:
Molecular & Cellular Proteomics. 12:913-920
Mice with null mutations in specific Golgi glycosyltransferases show evidence of glycan compensation where missing carbohydrate epitopes are found on biosynthetically related structures. Repetitive saccharide sequences within the larger glycan struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2f99e5b2c3e91f3e2d51974ebfffce
https://doi.org/10.1074/mcp.r112.026989
https://doi.org/10.1074/mcp.r112.026989
Autor:
Thomas A. Gerken, C. Fred Brewer, Tarun K. Dam, Bjørn T. Stokke, Marit Sletmoen, Kristin E. Haugstad
Publikováno v:
Biomacromolecules. 13:1400-1409
Mucins are linear O-glycosylated glycoproteins involved in inflammation, cell adhesion, and tumorigenesis. Cancer-associated mucins often possess increased expression of the T (Galβ1,3GalNAcαThr/Ser) and Tn (GalNAcαThr/Ser) cancer antigens, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c48836eed8d36a7af3cabfedca2f244
https://doi.org/10.1021/bm300135h
https://doi.org/10.1021/bm300135h
Autor:
Celso Shiniti Nagano, Kyria S. Nascimento, Luiz A. G. de Sousa, Benildo Sousa Cavada, Raquel G. Benevides, Tarun K. Dam, Stefan Oscarson, C. Fred Brewer, Bruno A.M. Rocha
Publikováno v:
Repositório Institucional do INPA
Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
The legume species of Cymbosema roseum of Diocleinae subtribe produce at least two different seed lectins. The present study demonstrates that C. roseum lectin I (CRL I) binds with high affinity to the "core" trimannoside of N-linked oligosaccharides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196ed97fd346827711a74442760b3148
https://doi.org/10.1093/glycob/cwr025
https://doi.org/10.1093/glycob/cwr025
Publikováno v:
Glycobiology. 20:1061-1064
It has been recently proposed that lectins such as galectins, C-type lectins and siglecs in innate immunity bind to foreign pathogens by density-dependent recognition of surface glycans (Dam and Brewer 2010). In many cases, foreign pathogens includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fbe9ad378f0a8158018240dc764a0e
https://doi.org/10.1093/glycob/cwq084
https://doi.org/10.1093/glycob/cwq084