Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Fred A Pereira"'
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183046 (2017)
The motor protein prestin is a member of the SLC26 family of anion antiporters and is essential to the electromotility of cochlear outer hair cells and for hearing. The only direct inhibitor of electromotility and the associated charge transfer is sa
Externí odkaz:
https://doaj.org/article/9ef6e888e79a466aab0e21beb95b0bbe
Autor:
Xiangling Meng, Wei Wang, Hui Lu, Ling-jie He, Wu Chen, Eugene S Chao, Marta L Fiorotto, Bin Tang, Jose A Herrera, Michelle L Seymour, Jeffrey L Neul, Fred A Pereira, Jianrong Tang, Mingshan Xue, Huda Y Zoghbi
Publikováno v:
eLife, Vol 5 (2016)
Many postnatal onset neurological disorders such as autism spectrum disorders (ASDs) and intellectual disability are thought to arise largely from disruption of excitatory/inhibitory homeostasis. Although mouse models of Rett syndrome (RTT), a postna
Externí odkaz:
https://doaj.org/article/e9b3e20a7632402da35d66faa9ebbd99
Autor:
Bum Jun Kim, Hitisha P Zaveri, Oleg A Shchelochkov, Zhiyin Yu, Andrés Hernández-García, Michelle L Seymour, John S Oghalai, Fred A Pereira, David W Stockton, Monica J Justice, Brendan Lee, Daryl A Scott
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57460 (2013)
Individuals with terminal and interstitial deletions of chromosome 1p36 have a spectrum of defects that includes eye anomalies, postnatal growth deficiency, structural brain anomalies, seizures, cognitive impairment, delayed motor development, behavi
Externí odkaz:
https://doaj.org/article/700fbc6dcbf8457bb3747ef6fc450a47
Autor:
Anping Xia, Yohan Song, Rosalie Wang, Simon S Gao, Will Clifton, Patrick Raphael, Sung-il Chao, Fred A Pereira, Andrew K Groves, John S Oghalai
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82602 (2013)
The outer hair cell (OHC) motor protein prestin is necessary for electromotility, which drives cochlear amplification and produces exquisitely sharp frequency tuning. Tecta(C1509G) transgenic mice have hearing loss, and surprisingly have increased OH
Externí odkaz:
https://doaj.org/article/77f7899eb22d440b86876df874f1f522
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83358 (2013)
Both nuclear receptor subfamily 2 group F member 1 (NR2F1) and microRNAs (miRNAs) have been shown to play critical roles in the developing and functional inner ear. Based on previous studies suggesting interplay between NR2F1 and miRNAs, we investiga
Externí odkaz:
https://doaj.org/article/0eac57accfa340af902f3704cf953ab2
Autor:
Celina Montemayor, Oscar A Montemayor, Alex Ridgeway, Feng Lin, David A Wheeler, Scott D Pletcher, Fred A Pereira
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8910 (2010)
BackgroundIdentification of bona fide direct nuclear receptor gene targets has been challenging but essential for understanding regulation of organismal physiological processes.ResultsWe describe a methodology to identify transcription factor binding
Externí odkaz:
https://doaj.org/article/83faa4233d134b97910d09598a4a0699
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5762 (2009)
Prestin, encoded by the gene SLC26A5, is a transmembrane protein of the cochlear outer hair cell (OHC). Prestin is required for the somatic electromotile activity of OHCs, which is absent in OHCs and causes severe hearing impairment in mice lacking p
Externí odkaz:
https://doaj.org/article/e380ca7617854219b3eacc459b49b748
Autor:
Hong Sun, Jeanne M. Manalo, Dalian Ding, John Hicks, Richard Salvi, Fred A. Pereira, Rodney E. Kellems, Yang Xia, Hong Liu
Publikováno v:
The FASEB Journal. 34:15771-15787
Over 466 million people worldwide are diagnosed with hearing loss (HL). About 90% of HL cases are sensorineural HL (SNHL) with treatments limited to hearing aids and cochlear implants with no FDA-approved drugs. Intriguingly, ADA-deficient patients h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f260fd4e2d45498699022520d31c7de2
https://doi.org/10.1096/fj.202000939r
https://doi.org/10.1096/fj.202000939r
Autor:
Gabriela Thatiana Silva Oliveira, Bruno Bonfim Foresti, Flávia Regina Ferreira Alves, Fred Henrique Pereira Faria, Luís Gustavo Rabello Oliveira
Publikováno v:
Interação - Revista de Ensino, Pesquisa e Extensão. 17:24-48
O presente trabalho verifica a consistência interna das baterias de testes de Motricidade Global e Equilíbrio, da escala de desenvolvimento motor, em alunos com Síndrome de Down (SD), inseridos no ensino fundamental. O método da pesquisa se carac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4306a7d5c67285f4747bd4ceb1581f
https://doi.org/10.33836/interacao.v17i17.74
https://doi.org/10.33836/interacao.v17i17.74
Autor:
Ayush T. Raman, Steen E. Pedersen, Wei Wang, Anping Xia, Fernanda R. Ruiz, Fred A. Pereira, Michelle L. Seymour, Jiani Yin, Christian P. Schaaf, Robia G. Pautler, Joanna Lopez, Meike E van der Heijden, Megan E. Rech, Huda Y. Zoghbi, Chun-An Chen, Samuel M. Wu, Li Wang, Zhandong Liu, Richard A. Lewis
Publikováno v:
Hum Mol Genet
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) has been identified as an autosomal-dominant disorder characterized by a complex neurological phenotype, with high prevalence of intellectual disability and optic nerve atrophy/hypoplasia. The syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235bc92395b71748a6548b2df6abea8b
https://europepmc.org/articles/PMC7104670/
https://europepmc.org/articles/PMC7104670/
