Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Fred Stappers"'
Autor:
Fred Stappers, Alfons Wouters, Koen Iterbeke, Francois Marc Karel Jozef, Guenter Kraus, Piet Wigerinck, Laurent Schueller, Lieven Baert, Pieter Van Remoortere, Esther Dina Guido Basstanie, Gerben Albert Eleutherius Van 'T Klooster, Willy Maria Albert Carlo Dries, Jan Rosier, Paul Stevens
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 72:502-508
Long-acting parenteral formulations of antiretrovirals could facilitate maintenance and prophylactic treatment in HIV. Using the poorly water- and oil-soluble non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278 (rilpivirine) as base or hydr
Autor:
Frank Meeussen, Dirk Van den Heuvel, Tom Callewaert, Peter Van der Donck, Erika De Bie, Didier Philippe Robert Schils, Ellen Schouteden, Fred Stappers, Michelle Coppens, Kristof Eersels, Richard van Heck, Geoffrey François Freddy Ghislain Solberghe
Publikováno v:
Organic Process Research & Development. 12:530-536
The aniline derivative 3 is a key building block of rilpivirine (TMC278) 2, a new potent NNRTI compound under clinical evaluation. In this paper we describe the development of a new synthesis of 3 based on a Heck coupling between a halogenated anilin
Autor:
Rudy Laurent Maria Broeckx, Annemie Lambrechts, Fred Stappers, Jos Agten, Leo Van den Bergh, Dirk Van Den Heuvel, Stef Leurs, Dirk De Smaele
Publikováno v:
Organic Process Research & Development. 6:911-914
The stepwise optimization towards a safe, reproducible, and high-yielding oxidation of azepine 2 into the prochiral nitrone 4 is described, with emphasis on the elimination of Davis reagent 3. m-Chloroperoxybenzoic acid (mCPBA) was found to be an ele
Autor:
Didier Schils, Fred Stappers, Geoffrey Solberghe, Richard van Heck, Michelle Coppens, Dirk Van den Heuvel, Peter Van der Donck, Tom Callewaert, Frank Meeussen, Erika De Bie, Kristof Eersels, Ellen Schouteden
Publikováno v:
Organic Process Research & Development; Apr2008, Vol. 12 Issue 3, p530-536, 7p