Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Fred, van Leeuwen"'
Autor:
Eliza Mari Kwesi-Maliepaard, Muddassir Malik, Tibor van Welsem, Remco van Doorn, Maarten H. Vermeer, Hanneke Vlaming, Heinz Jacobs, Fred van Leeuwen
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Cutaneous T-cell lymphomas (CTCLs) are a subset of T-cell malignancies presenting in the skin. The treatment options for CTCL, in particular in advanced stages, are limited. One of the emerging therapies for CTCL is treatment with histone deacetylase
Externí odkaz:
https://doaj.org/article/b241d9f6d9584cc68a04b26f8668305b
Autor:
Leonie Kollenstart, Sophie C. van der Horst, Kees Vreeken, George M. C. Janssen, Fabrizio Martino, Hanneke Vlaming, Peter A. van Veelen, Fred van Leeuwen, Haico van Attikum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations, such as crotonylation, succinylation and butyrylation, yet their regulation is still
Externí odkaz:
https://doaj.org/article/49d63814a9b84605a12502b41eee17ad
Publikováno v:
Epigenetics, Vol 15, Iss 9, Pp 901-913 (2020)
In eukaryotes, nucleosomes form a barrier to DNA templated reactions and must be dynamically disrupted to provide access to the genome. During nucleosome (re)assembly, histones can be replaced by new histones, erasing post-translational modifications
Externí odkaz:
https://doaj.org/article/34abaaa08dc04d8cac74ce00d21ad4c1
Autor:
Tomasz Ahrends, Julia Busselaar, Tesa M. Severson, Nikolina Bąbała, Evert de Vries, Astrid Bovens, Lodewyk Wessels, Fred van Leeuwen, Jannie Borst
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Help from CD4+ T cells is important to induce CD8+ T cell memory responses, but mechanistic insights are lacking. Here, the authors show, by transcriptomics and epigenetics, how CD4+ T cells help program memory CD8+ T cells for help-independent recal
Externí odkaz:
https://doaj.org/article/5213f8fbacb34ae3ab044b7181b1b063
Publikováno v:
Nature structural & molecular biology, 30(5), 692-702. Nature Publishing Group
SummaryTranscriptional bursting has been linked to the stochastic positioning of nucleosomes. However, how bursting is regulated by remodeling of promoter nucleosomes is unknown. Here, we use single-molecule live-cell imaging of GAL10 transcription i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ad21771d3c0bf2b59c56f371ae6c73
http://www.scopus.com/inward/record.url?scp=85154583797&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85154583797&partnerID=8YFLogxK
Autor:
Ila van Kruijsbergen, Monique P. C. Mulder, Michael Uckelmann, Tibor van Welsem, John de Widt, Aldo Spanjaard, Heinz Jacobs, Farid El Oualid, Huib Ovaa, Fred van Leeuwen
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a lysine of a protein substrate. In addition to its wel
Externí odkaz:
https://doaj.org/article/96f73bcacfac4bcd927a6cd4d515cee0
Autor:
Maria Elize van Breugel, Ila van Kruijsbergen, Chitvan Mittal, Cor Lieftink, Ineke Brouwer, Teun van den Brand, Roelof J.C. Kluin, Renée Menezes, Tibor van Welsem, Andrea Del Cortona, Muddassir Malik, Roderick Beijersbergen, Tineke L. Lenstra, Kevin Verstrepen, B. Franklin Pugh, Fred van Leeuwen
Transcription of tRNA genes by RNA Polymerase III (RNAPIII) is tightly regulated by signaling cascades in response to nutrient availability. The emerging notion of differential tRNA gene regulation implies the existence of additional regulatory mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450e3afa694379345ae6e5cb84f4831f
https://doi.org/10.1101/2023.04.17.534528
https://doi.org/10.1101/2023.04.17.534528
Autor:
Marlize Van Breugel, Fred Van Leeuwen
Publikováno v:
Methods in Molecular Biology ISBN: 9781071621394
Methods in Molecular Biology, 2458, 123-150
Methods in Molecular Biology, 2458, 123-150
The genome in a eukaryotic cell is packaged into chromatin and regulated by chromatin-binding and chromatin-modifying factors. Many of these factors and their complexes have been identified before, but how each genomic locus interacts with its surrou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fac92b6ee1c50984fd2d2556cbc0e3c
http://www.scopus.com/inward/record.url?scp=85123967468&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85123967468&partnerID=8YFLogxK
Autor:
Tessy Korthout, Deepani W Poramba-Liyanage, Ila van Kruijsbergen, Kitty F Verzijlbergen, Frank P A van Gemert, Tibor van Welsem, Fred van Leeuwen
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2005542 (2018)
Transcription, replication, and repair involve interactions of specific genomic loci with many different proteins. How these interactions are orchestrated at any given location and under changing cellular conditions is largely unknown because systema
Externí odkaz:
https://doaj.org/article/0074c10b0715470d9cccd82434924638
Autor:
Lisa Willemsen, Koen H.M. Prange, Annette E. Neele, Cindy P.A.A. van Roomen, Marion Gijbels, Guillermo R. Griffith, Myrthe den Toom, Linda Beckers, Ricky Siebeler, Nathanael J. Spann, Hung-Jen Chen, Laura A. Bosmans, Andrej Gorbatenko, Suzanne van Wouw, Noam Zelcer, Heinz Jacobs, Fred van Leeuwen, Menno P.J. de Winther
Publikováno v:
Cell Reports, 41(8):111703. Cell Press
Cell reports, 41(8):111703. Cell Press
Cell reports, 41(8):111703. Cell Press
Macrophages are critical immune cells in inflammatory diseases, and their differentiation and function are tightly regulated by histone modifications. H3K79 methylation is a histone modification associated with active gene expression, and DOT1L is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05bb3dde3236461fb0442e54d9df7cd
https://cris.maastrichtuniversity.nl/en/publications/8e61cfc8-7c5e-4e6b-ab6b-cb1ba514a359
https://cris.maastrichtuniversity.nl/en/publications/8e61cfc8-7c5e-4e6b-ab6b-cb1ba514a359