Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Fred, Van Leuven"'
Autor:
Jan R. Detrez, Hervé Maurin, Kristof Van Kolen, Roland Willems, Julien Colombelli, Benoit Lechat, Bart Roucourt, Fred Van Leuven, Sarah Baatout, Peter Larsen, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 398-409 (2019)
We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated tau in intact, cleared mouse brain. We found that the three-dimensional spreading pattern of hyperphosphorylated tau in the brain of an aging Tau.P301L
Externí odkaz:
https://doaj.org/article/119ac8d690064ea99cc5b5a136436f56
Autor:
Reynald Thinard, Attila E. Farkas, Marta Halasa, Melanie Chevalier, Klaudia Brodaczewska, Aleksandra Majewska, Robert Zdanowski, Maria Paprocka, Joanna Rossowska, Lam Tri Duc, Ruth Greferath, Istvan Krizbai, Fred Van Leuven, Claudine Kieda, Claude Nicolau
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1418 (2022)
The failures of anti-β-amyloid immunotherapies suggested that the very low fraction of injected antibodies reaching the brain parenchyma due to the filtering effect of the BBB may be a reason for the lack of therapeutic effect. However, there is no
Externí odkaz:
https://doaj.org/article/f2ca718d6f6f42728c8cd75edc64c9f7
Autor:
Malgorzata Urbanska, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Bartosz Caban, Karolina Nader, Barbara Pijet, Katarzyna Kalita, Agata Gozdz, Herman Devijver, Benoit Lechat, Tomasz Jaworski, Wieslawa Grajkowska, Krzysztof Sadowski, Sergiusz Jozwiak, Katarzyna Kotulska, Jan Konopacki, Fred Van Leuven, Erwin A. van Vliet, Eleonora Aronica, Jacek Jaworski
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 377-387 (2019)
Background: Glycogen synthase kinase-3β (GSK3β) is a key regulator of cellular homeostasis. In neurons, GSK3β contributes to the control of neuronal transmission and plasticity, but its role in epilepsy remains to be defined. Methods: Biochemical
Externí odkaz:
https://doaj.org/article/ccb24ce7f72a4cd2a2d94b67aaf14db7
Autor:
Ana I. Rojo, Marta Pajares, Angel J. García-Yagüe, Izaskun Buendia, Fred Van Leuven, Masayuki Yamamoto, Manuela G. López, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 173-180 (2018)
Chronic neuroinflammation is a hallmark of the onset and progression of brain proteinopathies such as Alzheimer disease (AD) and it is suspected to participate in the neurodegenerative process. Transcription factor NRF2, a master regulator of redox h
Externí odkaz:
https://doaj.org/article/b2146730596b411ea0a1cdc33d1d8c9a
Autor:
Ana I. Rojo, Marta Pajares, Patricia Rada, Angel Nuñez, Alejo J. Nevado-Holgado, Richard Killik, Fred Van Leuven, Elena Ribe, Simon Lovestone, Masayuki Yamamoto, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 444-451 (2017)
Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional
Externí odkaz:
https://doaj.org/article/d68186949f744c309d22a00c4b5bae87
Autor:
Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Hervé Maurin, Fred Van Leuven
Publikováno v:
Neurobiology of Disease, Vol 67, Iss , Pp 119-132 (2014)
Tau.P301L transgenic mice suffer precocious mortality between ages 8 and 11 months, resulting from upper airway defects caused by tauopathy in autonomic brainstem circuits that control breathing (Dutschmann et al., 2010). In individual mice, the clin
Externí odkaz:
https://doaj.org/article/2e7701d84aea4ee39f0cda292ac223f9
Autor:
Najat Aourz, Fred Van Leuven, Wissal Allaoui, Ann Van Eeckhaut, Dimitri De Bundel, Ilse Smolders
Publikováno v:
ACS chemical neuroscience. 13(6)
Two closely related glycogen synthase kinase-3 (GSK-3) isoforms have been identified in mammals: GSK-3α and GSK-3β. GSK-3β is the most prominent in the central nervous system and was previously shown to control neuronal excitability. We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51808db067a1ae83eb9520ee0b982231
https://pubmed.ncbi.nlm.nih.gov/35253420
https://pubmed.ncbi.nlm.nih.gov/35253420
Autor:
Clément Menuet, Peter Borghgraef, Nicolas Voituron, Christian Gestreau, Lies Gielis, Herman Devijver, Mathias Dutschmann, Fred Van Leuven, Gérard Hilaire
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 1, Pp 234-243 (2012)
The postoperative cognitive decline resulting from volatile anesthesia is gaining acceptance as a major health problem. The common anesthetic isoflurane is suspected to precipitate neurodegeneration in Alzheimer's disease by unknown mechanisms. We pr
Externí odkaz:
https://doaj.org/article/a5268d9fe2e34d229feea7cad3875dc0
Autor:
Seon-Ah Chong, Iryna Benilova, Hamdy Shaban, Bart De Strooper, Herman Devijver, Dieder Moechars, Wolfgang Eberle, Carmen Bartic, Fred Van Leuven, Geert Callewaert
Publikováno v:
Neurobiology of Disease, Vol 44, Iss 3, Pp 284-291 (2011)
APP.V717I and Tau.P301L transgenic mice develop Alzheimer's disease pathology comprising important aspects of human disease including increased levels of amyloid peptides, cognitive and motor impairment, amyloid plaques and neurofibrillary tangles. T
Externí odkaz:
https://doaj.org/article/31bb7ad6c2b84d6eb980e9b20926141c
Autor:
Lut Van Laer, Markus Pfister, Sofie Thys, Karen Vrijens, Marcus Mueller, Lieve Umans, Lutgarde Serneels, Luc Van Nassauw, Frank Kooy, Richard J.H. Smith, Jean-Pierre Timmermans, Fred Van Leuven, Guy Van Camp
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 3, Pp 386-399 (2005)
A complex mutation in DFNA5, resulting in exon 8 skipping, causes autosomal dominant hearing impairment, which starts in the high frequencies between 5 and 15 years of age and progressively affects all frequencies. To study its function in vivo, Dfna
Externí odkaz:
https://doaj.org/article/6ee8f17ce2b349d3973f858625b9fcf8