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Antidepressants bind to cholesterol-interaction motif of TRKB neurotrophin receptor

Autor: Casarotto, Plinio C, Girych, Mykhailo, Fred, Senem M, Moliner, Rafael, Enkavi, Giray, Biojone, Caroline, Cannarozzo, Cecilia, Brunello, Cecilia A, Steinzeig, Anna, Winkel, Frederike, Patil, Sudarshan, Vestring, Stefan, Serchov, Tsvetan, Kovaleva, Vera, Diniz, Cassiano RAF, Laukkanen, Liina, Cardon, Iseline, Antila, Hanna, Rog, Tomasz, Saarma, Mart, Bramham, Clive R, Normann, Claus, Lauri, Sari E, Vattulainen, Ilpo, Castrén, Eero

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of TRKB, a BDNF receptor promoting neuronal plasticity and antidepressant responses, has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::44cec48445321f548ec8d7d0cbb51b41

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.

Autor: Casarotto PC; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Girych M; Department of Physics, University of Helsinki, Helsinki, Finland., Fred SM; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Kovaleva V; Institute of Biotechnology-HILIFE, University of Helsinki, Helsinki, Finland., Moliner R; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Enkavi G; Department of Physics, University of Helsinki, Helsinki, Finland., Biojone C; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Cannarozzo C; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Sahu MP; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Kaurinkoski K; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Brunello CA; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Steinzeig A; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Winkel F; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Patil S; Department of Biomedicine and KG Jebsen Center for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway., Vestring S; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Serchov T; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Diniz CRAF; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paul, Brazil., Laukkanen L; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland., Cardon I; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland; Brain Master Program, Faculty of Science, Aix-Marseille Université, Marseille, France; Department of Psychiatry, University of Regensburg, Regenburg, Germany., Antila H; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rog T; Department of Physics, University of Helsinki, Helsinki, Finland., Piepponen TP; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Bramham CR; Department of Biomedicine and KG Jebsen Center for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway., Normann C; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Basics in Neuromodulation (NeuroModul Basics), University of Freiburg, Freiburg, Germany., Lauri SE; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland; Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland., Saarma M; Institute of Biotechnology-HILIFE, University of Helsinki, Helsinki, Finland., Vattulainen I; Department of Physics, University of Helsinki, Helsinki, Finland; Computational Physics Laboratory, Tampere University, Tampere, Finland., Castrén E; Neuroscience Center-HILIFE, University of Helsinki, Helsinki, Finland. Electronic address: eero.castren@helsinki.fi.

Publikováno v: Cell [Cell] 2021 Mar 04; Vol. 184 (5), pp. 1299-1313.e19. Date of Electronic Publication: 2021 Feb 18.