Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Fred, Lühder"'
Autor:
Rouven Wannemacher, Anna Reiß, Karl Rohn, Fred Lühder, Alexander Flügel, Wolfgang Baumgärtner, Kirsten Hülskötter
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Theiler’s murine encephalomyelitis virus (TMEV) is the causative agent of TMEV-induced demyelinating disease (TMEV-IDD); a well-established animal model for the chronic progressive form of human multiple sclerosis (MS). In susceptible mice with an
Externí odkaz:
https://doaj.org/article/dc41585ec46a4ed4ac0ffeef3b24ab26
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The intracerebral infection of mice with Theiler’s murine encephalomyelitis virus (TMEV) represents a well-established animal model for multiple sclerosis (MS). Because CD28 is the main co-stimulatory molecule for the activation of T cells, we want
Externí odkaz:
https://doaj.org/article/9a686f2e54524f478050c94e5e6f5880
Autor:
Maud Bagnoud, Jana Remlinger, Marine Massy, Dmitri Lodygin, Anke Salmen, Andrew Chan, Fred Lühder, Robert Hoepner
Publikováno v:
Cells, Vol 12, Iss 18, p 2291 (2023)
Our previous work demonstrated that vitamin D (VitD) reduces experimental autoimmune encephalomyelitis (EAE) disease severity in wild-type (WT) but not in T cell-specific glucocorticoid (GC) receptor (GR)-deficient (GRlck) mice. This study aimed to i
Externí odkaz:
https://doaj.org/article/4ae99d68e0e4461abc1f44b3752bd976
Autor:
Asmma Doudin, Theresa Riebeling, Julia Staab, Priyanka Rajeev Menon, Fred Lühder, Oliver Wirths, Uwe Vinkemeier, Aleksandar Ivetic, Thomas Meyer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
In this study, we addressed the functional significance of co-operative DNA binding of the cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) in an experimental murine model of acute myocardial infarction
Externí odkaz:
https://doaj.org/article/6e99cd63699844a09ecde075a375803b
Autor:
Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affected subjects develops modera
Externí odkaz:
https://doaj.org/article/d1c0fb1e847c4676a294adfd696ee12d
Autor:
Lisa Thiele née Schrewe, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner, Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder, Stefan Wiese, Andrew Chan
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-9 (2020)
Abstract Background The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribin
Externí odkaz:
https://doaj.org/article/7192c5f5a49342408e5e811a46b98eff
Autor:
Leonie Meyer-Heemsoth, Katja Mitschke, Jasmina Bier, Konstantin Schütz, Andreas Villunger, Tobias J. Legler, Martin S. Weber, Fred Lühder, Holger M. Reichardt
Publikováno v:
Cells, Vol 12, Iss 3, p 450 (2023)
Glucocorticoids (GCs) are used to treat inflammatory disorders such as multiple sclerosis (MS) by exerting prominent activities in T cells including apoptosis induction and suppression of cytokine production. However, little is known about their impa
Externí odkaz:
https://doaj.org/article/7aa68e66f5924d57a5e3dda753c2a6fd
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Induction of T cell apoptosis constitutes a major mechanism by which therapeutically administered glucocorticoids (GCs) suppress inflammation and associated clinical symptoms, for instance in multiple sclerosis (MS) patients suffering from an acute r
Externí odkaz:
https://doaj.org/article/61f64426410445719c02ef8c2395a8a4
Autor:
Sybille D. Reichardt, Agathe Amouret, Chiara Muzzi, Sabine Vettorazzi, Jan P. Tuckermann, Fred Lühder, Holger M. Reichardt
Publikováno v:
Cells, Vol 10, Iss 11, p 2921 (2021)
For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being m
Externí odkaz:
https://doaj.org/article/8259bbf6ae884f8d95dec4607745f541
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8486 (2021)
Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose tamo
Externí odkaz:
https://doaj.org/article/9174825627d5476683a1d10bb8914de2