Výsledky vyhledávání - "Fred, Immermann"

Evaluation of a Validated Luminex-Based Multiplex Immunoassay for Measuring Immunoglobulin G Antibodies in Serum to Pneumococcal Capsular Polysaccharides

Autor: Danka Pavliakova, Daniel A. Scott, Fred Immermann, Mohinder Sidhu, Wendy Watson, Kelly A. Belanger, Shite Sebastian, Peter C. Giardina, Michael W. Pride, Charles Tan, Kathrin U. Jansen

Publikováno v: mSphere, Vol 3, Iss 4, p e00127-18 (2018)
mSphere, Vol 3, Iss 4 (2018)
mSphere

The pneumococcal enzyme-linked immunosorbent assay (ELISA) measures IgG antibodies in human serum, and it is an important assay that supports licensure of pneumococcal vaccines. The immune correlate of protection, 0.35 µg/ml of IgG antibodies, was d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fd2bed210d48256954fc0181fbc44c
https://doaj.org/article/1ae71448fc6945e886c0bb01e03c7316

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The Biomarkers of Lupus Disease Study: A Bold Approach May Mitigate Interference of Background Immunosuppressants in Clinical Trials

Autor: Joel M. Guthridge, Joan T. Merrill, Padmalatha S. Reddy, Maryann Z. Whitley, Fred Immermann, Sudhakar Sridharan, Margot O'Toole, Tianhui Zhou, Marek Honczarenko, Joe Rawdon, Andrew A. Hill, Aikaterini Thanou, Judith A. James

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 69(6)

Objective Molecular medicine raised expectations for strategically targeted biologic agents in systemic lupus erythematosus (SLE), but clinical trial results have been disappointing and difficult to interpret. Most studies add investigational agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa164528b0ab4da1e965ab62a77a10e2
https://pubmed.ncbi.nlm.nih.gov/28435152

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Opportunities posed by novel patient selection biomarker approaches in oncology drug development: going beyond the cytotoxics

Autor: John Alvarez, Christina Marie Coughlin, Richat Abbas, Michael E. Burczynski, Fred Immermann, Grant Sellar, Frank Loganzo, Maha Karnoub, Giora Feuerstein

Publikováno v: Biomarkers in Medicine. 2:147-153

An area of unmet medical need in clinical oncology has been optimizing patient selection for a given therapeutic with the goal of getting the right drug to the right patient. Recent studies have developed preclinical approaches to identifying molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af0a397b0595317d0d930171b909949
https://doi.org/10.2217/17520363.2.2.147

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Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma

Autor: Janice P. Dutcher, Fred Immermann, Donna K. Slonim, Andrew J. Dorner, Manuel Hidalgo, William L. Trepicchio, Bonnie Marshall, Theodore F. Logan, Gary Dukart, Andrew Strahs, Michael E. Burczynski, Walter M. Stadler, Gary R. Hudes, Natalie C. Twine

Publikováno v: Clinical Cancer Research. 11:1181-1189

Purpose: Given their accessibility, surrogate tissues, such as peripheral blood mononuclear cells (PBMC), may provide potential predictive biomarkers in clinical pharmacogenomic studies. In leukemias and lymphomas, the prognostic value of peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d38dfc8aa64471578daaa39c4cf4d6
https://doi.org/10.1158/1078-0432.1181.11.3

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Population pharmacokinetics of CCI-779: Correlations to safety and pharmacogenomic responses in patients with advanced renal cancer

Autor: Cathie Leister, Joseph Boni, Gregor Bender, Fred Immermann, Natalie C. Twine, Virginia Fitzpatrick, Michael E. Burczynski, Jennifer Ann Stover, Andrew J. Dorner

Publikováno v: Clinical Pharmacology & Therapeutics. 77:76-89

Objective Our objective was to estimate the pharmacokinetic parameters of CCI-779 and its metabolite, sirolimus, and evaluate associations of exposure parameters with safety and clinical activity. Exposure parameters were also correlated with pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d363fe933af592035c26ef5b21c7ae2
https://doi.org/10.1016/j.clpt.2004.08.025

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Abstract 1469: Patient derived xenograft (PDX) models: improving predictability of experimental cancer therapies

Autor: Zhengyan Kan, James S. Hardwick, Hans-Peter Gerber, Judy Lucas, Fred Immermann, Danielle Leahy, Jonathon Golas, Justin Lucas, Paul A. Rejto, Edward Rosfjord, Erik Upeslacis, Jeremy S. Myers, Puja Sapra, Eric L. Powell, Xin Han, Andrea T. Hooper, Bingwen Lu

Publikováno v: Cancer Research. 75:1469-1469

Clinical development of cancer therapies is associated with attrition rates as high as 80-95%. This high attrition suggests that standard preclinical pharmacology models do not accurately reflect clinical responses. The development of more predictive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::999ac491715df700806c5fd6fecb0771
https://doi.org/10.1158/1538-7445.am2015-1469

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Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells

Autor: Michael E. Burczynski, Padma S. Reddy, Anna M. Slager, Monette M. Cotreau, Natalie C. Twine, Walter Spinelli, Ulrich Schwertschlag, Brendan J. Brodeur, Andrew Strahs, Fred Immermann, Ron L. Peterson, Andrew J. Dorner, Vasu Maganti, Lori Casciotti, Krystyna Zuberek

Publikováno v: The Journal of molecular diagnostics : JMD. 8(1)

Ulcerative colitis (UC) and Crohn's disease (CD) are common inflammatory bowel diseases producing intestinal inflammation and tissue damage. Although emerging evidence suggests these diseases are distinct, approximately 10% of patients remain classif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e46ae1f4d0c1f22708c2bc4cbc0d91
https://pubmed.ncbi.nlm.nih.gov/16436634

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Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma

Autor: Michael E, Burczynski, Natalie C, Twine, Gary, Dukart, Bonnie, Marshall, Manuel, Hidalgo, Walter M, Stadler, Theodore, Logan, Janice, Dutcher, Gary, Hudes, William L, Trepicchio, Andrew, Strahs, Fred, Immermann, Donna K, Slonim, Andrew J, Dorner

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 11(3)

Given their accessibility, surrogate tissues, such as peripheral blood mononuclear cells (PBMC), may provide potential predictive biomarkers in clinical pharmacogenomic studies. In leukemias and lymphomas, the prognostic value of peripheral blast exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8717b6c8347cb7fa881cdade34221cde
https://pubmed.ncbi.nlm.nih.gov/15709187

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