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of 3 769
pro vyhledávání: '"Frayling"'
The challenge of accessing historical patient data for clinical research, while adhering to privacy regulations, is a significant obstacle in medical science. An innovative approach to circumvent this issue involves utilising synthetic medical record
Externí odkaz:
http://arxiv.org/abs/2403.08664
Autor:
Gareth Hawkes, Robin N. Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Christine M. Albert, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, Eric Boerwinkle, Jennifer A. Brody, April P. Carson, Nathalie Chami, Yii-Der Ida Chen, Mina K. Chung, Joanne E. Curran, Dawood Darbar, Patrick T. Ellinor, Myrian Fornage, Victor R. Gordeuk, Xiuqing Guo, Jiang He, Chii-Min Hwu, Rita R. Kalyani, Robert Kaplan, Sharon L. R. Kardia, Charles Kooperberg, Ruth J. F. Loos, Steven A. Lubitz, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Braxton D. Mitchell, Joanne M. Murabito, Nicholette D. Palmer, Bruce M. Psaty, Susan Redline, M. Benjamin Shoemaker, Edwin K. Silverman, Marilyn J. Telen, Scott T. Weiss, Lisa R. Yanek, Hufeng Zhou, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ching-Ti Liu, Kari E. North, Anne E. Justice, Jonathan M. Locke, Nick Owens, Anna Murray, Kashyap Patel, Timothy M. Frayling, Caroline F. Wright, Andrew R. Wood, Xihong Lin, Alisa Manning, Michael N. Weedon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100
Externí odkaz:
https://doaj.org/article/b2e3a91ecb614324b7f2fdd7370d5155
Incorporating conversational context and knowledge into dialogue generation models has been essential for improving the quality of the generated responses. The context, comprising utterances from previous dialogue exchanges, is used as a source of co
Externí odkaz:
http://arxiv.org/abs/2305.18200
Autor:
Abdelali, Ahmed, Mubarak, Hamdy, Chowdhury, Shammur Absar, Hasanain, Maram, Mousi, Basel, Boughorbel, Sabri, Kheir, Yassine El, Izham, Daniel, Dalvi, Fahim, Hawasly, Majd, Nazar, Nizi, Elshahawy, Yousseif, Ali, Ahmed, Durrani, Nadir, Milic-Frayling, Natasa, Alam, Firoj
Recent advancements in Large Language Models (LLMs) have significantly influenced the landscape of language and speech research. Despite this progress, these models lack specific benchmarking against state-of-the-art (SOTA) models tailored to particu
Externí odkaz:
http://arxiv.org/abs/2305.14982
Autor:
Junxi Liu, Rebecca C. Richmond, Emma L. Anderson, Jack Bowden, Ciarrah-Jane S. Barry, Hassan S. Dashti, Iyas S. Daghlas, Jacqueline M. Lane, Simon D. Kyle, Céline Vetter, Claire L. Morrison, Samuel E. Jones, Andrew R. Wood, Timothy M. Frayling, Alison K. Wright, Matthew J. Carr, Simon G. Anderson, Richard A. Emsley, David W. Ray, Michael N. Weedon, Richa Saxena, Martin K. Rutter, Deborah A. Lawlor
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian random
Externí odkaz:
https://doaj.org/article/7570bd5e2c7049fda1219de8ef4b9840
Autor:
Coviello, Andrea D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimaki, Terho, Keildson, Sarah, Lunetta, Kathryn L., He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Mei, Yong, Koster, Annemarie, Lohman, Kurt, Lyytikainen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R., Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania, Biffar, Reiner, Brabant, Georg, Cox, David G., Chen, Yuhui, Cummings, Steven, Ferrucci, Luigi, Gunter, Marc J., Hankinson, Susan E., Martikainen, Hannu, Hofman, Albert, Homuth, Georg, Illig, Thomas, Jansson, John-Olov, Johnson, Andrew D., Karasik, David, Karlsson, Magnus, Kettunen, Johannes, Kiel, Douglas P., Kraft, Peter, Liu, Jingmin, Ljunggren, Östen, Lorentzon, Mattias, Maggio, Marcello, Markus, Marcello R. P., Mellstrom, Dan, Miljkovic, Iva, Mirel, Daniel, Nelson, Sarah, Papunen, Laure Morin, Peeters, Petra H. M., Prokopenko, Inga, Raffel, Leslie, Reincke, Martin, Reiner, Alex P., Rexrode, Kathryn, Rivadeneira, Fernando, Schwartz, Stephen M., Siscovick, David, Soranzo, Nicole, Stockl, Doris, Tworoger, Shelley, Uitterlinden, Andre G., van Gils, Carla H., Vasan, Ramachandran S., Wichmann, H. -Erich, Zhai, Guangju, Bhasin, Shalender, Bidlingmaier, Martin, Chanock, Stephen J., De Vivo, Immaculata, Harris, Tamara B., Hunter, David J., Kahonen, Mika, Liu, Simin, Ouyang, Pamela, Spector, Tim D., van der Schouw, Yvonne T., Viikari, Jorma, Wallaschofski, Henri, McCarthy, Mark I., Frayling, Timothy M., Murray, Anna, Franks, Steve, Jarvelin, Marjo-Riitta, de Jong, Frank H., Raitakari, Olli, Teumer, Alexander, Ohlsson, Claes, Murabito, Joanne M., Perry, John R. B.
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181141
Autor:
Katherine S. Ruth, Robin N. Beaumont, Jonathan M. Locke, Jessica Tyrrell, Carolyn J. Crandall, Gareth Hawkes, Timothy M. Frayling, Julia K. Prague, Kashyap A. Patel, Andrew R. Wood, Michael N. Weedon, Anna Murray
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-11 (2023)
Abstract Background Vasomotor symptoms (VMS) can often significantly impact women’s quality of life at menopause. In vivo studies have shown that increased neurokinin B (NKB) / neurokinin 3 receptor (NK3R) signalling contributes to VMS, with previo
Externí odkaz:
https://doaj.org/article/145ca60b899e4205aab6ed58c64c7ff5