Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Fraydoon, Rastinejad"'
Autor:
Karolína Ondrová, Iveta Zůvalová, Barbora Vyhlídalová, Kristýna Krasulová, Eva Miková, Radim Vrzal, Petr Nádvorník, Binod Nepal, Sandhya Kortagere, Martina Kopečná, David Kopečný, Marek Šebela, Fraydoon Rastinejad, Hua Pu, Miroslav Soural, Katharina Maria Rolfes, Thomas Haarmann-Stemmann, Hao Li, Sridhar Mani, Zdeněk Dvořák
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The human aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is a pivotal regulator of human physiology and pathophysiology. Allosteric inhibition of AhR was previously thought to be untenable. Here, we identify
Externí odkaz:
https://doaj.org/article/269654521e354a11b792e6976398f868
Autor:
Fraydoon Rastinejad
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a multi-faceted nuclear receptor responsible for governing the development and proper functioning of liver and pancreatic islet cells. Its transcriptional functions encompass the regulation of vital metab
Externí odkaz:
https://doaj.org/article/16a20076b3774edf8eca3aa0bbcfdc27
Autor:
Xiaotong Diao, Fei Ye, Meina Zhang, Xintong Ren, Xiaoxu Tian, Jingping Lu, Xiangnan Sun, Zeng Hou, Xiaoyu Chen, Fengwei Li, Jingjing Zhuang, Hong Ding, Chao Peng, Fraydoon Rastinejad, Cheng Luo, Dalei Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Whether hypoxia-inducible factors (HIFs) can be directly regulated by endogenous small molecules is a long-standing question. Here authors identified the metabolite oleoylethanolamide as a HIF-3α ligand and further revealed its mechanism of action.
Externí odkaz:
https://doaj.org/article/3f12a7f39e5c4af89eb48bcbee994f58
Autor:
Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Pawel Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason Matthews, Julie De Smedt, Liesbeth Minnoye, Ricardo Amorim, Sepideh Khorasanizadeh, Qian Yu, Liyun Zhao, Marie De Borre, Savvas N. Savvides, M. Celeste Simon, Peter Carmeliet, Wolf Reik, Fraydoon Rastinejad, Massimiliano Mazzone, Bernard Thienpont, Diether Lambrechts
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-36 (2020)
Abstract Background Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcription
Externí odkaz:
https://doaj.org/article/0d2e5621f90946fca225694fec6726cc
Autor:
Jana Flegel, Saad Shaaban, Zhi Jun Jia, Britta Schulte, Yilong Lian, Adrian Krzyzanowski, Malte Metz, Tabea Schneidewind, Fabian Wesseler, Anke Flegel, Alisa Reich, Alexandra Brause, Gang Xue, Minghao Zhang, Lara Dötsch, Isabelle D. Stender, Jan-Erik Hoffmann, Rebecca Scheel, Petra Janning, Fraydoon Rastinejad, Dennis Schade, Carsten Strohmann, Andrey P. Antonchick, Sonja Sievers, Pedro Moura-Alves, Slava Ziegler, Herbert Waldmann
Publikováno v:
Journal of Medicinal Chemistry. 65:16268-16289
Identification and analysis of small molecule bioactivity in target-agnostic cellular assays and monitoring changes in phenotype followed by identification of the biological target are a powerful approach for the identification of novel bioactive che
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2020)
Vitamin D and all its metabolites are bound to a specific vitamin D binding protein, DBP. This protein was originally first discovered by its worldwide polymorphism and called Group-specific Component (GC). We now know that DBP and GC are the same pr
Externí odkaz:
https://doaj.org/article/9762ffcd985b4758a0065953284153e7
Autor:
Xiangnan Sun, Linqian Jing, Fengwei Li, Meina Zhang, Xiaotong Diao, Jingjing Zhuang, Fraydoon Rastinejad, Dalei Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(46)
Neuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional regulator whose dysfunction has been linked to a variety of neuropsychiatric and metabolic diseases. As a member of the basic helix–loop–helix PER-ARNT-SIM (bHLH
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands
Externí odkaz:
https://doaj.org/article/a6df162dc85447f4af921752869d12fa
Autor:
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, Gabriel D. D’Agostino, Minghao Zhang, Eunha Kim, Eric A. Franzosa, Julian Avila-Pacheco, Jordan E. Bisanz, Christopher K. Rakowski, Hera Vlamakis, Ramnik J. Xavier, Peter J. Turnbaugh, Randy S. Longman, Michael R. Krout, Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin
Publikováno v:
Nature
The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (T(H)17 cells). We previously reported that the bile acid (BA) metabolite 3-oxo
Autor:
Maddalena Parafati, R. Jason Kirby, Sepideh Khorasanizadeh, Fraydoon Rastinejad, Siobhan Malany
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stre
Externí odkaz:
https://doaj.org/article/a208db7eeeb9406989c6ccad55d6a5a3