Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Frauke van Bebber"'
Autor:
Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)
Abstract Background The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in the cytoplasm is still poorly understood since TDP-43 animal models re
Externí odkaz:
https://doaj.org/article/3a903ab063944d74afd22278e76a4d88
Autor:
Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Vikas Bansal, Sebastian A. Lewandowski, Denise Orozco, Dieter Edbauer, Stefan Bonn, Christian Haass, Ulrich Pohl, Eloi Montanez, Bettina Schmid
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knocko
Externí odkaz:
https://doaj.org/article/41783c87576d4c5381ad20b7824e8c6c
Autor:
Alessandro Zambusi, Klara Tereza Novoselc, Saskia Hutten, Sofia Kalpazidou, Christina Koupourtidou, Rico Schieweck, Sven Aschenbroich, Lara Silva, Ayse Seda Yazgili, Frauke van Bebber, Bettina Schmid, Gabriel Möller, Clara Tritscher, Christian Stigloher, Claire Delbridge, Swetlana Sirko, Zeynep Irem Günes, Sabine Liebscher, Jürgen Schlegel, Hananeh Aliee, Fabian Theis, Silke Meiners, Michael Kiebler, Dorothee Dormann, Jovica Ninkovic
Publikováno v:
Nature neuroscience 25(12), 1608-1625 (2022). doi:10.1038/s41593-022-01199-y
Decreasing the activation of pathology-activated microglia is crucial to prevent chronic inflammation and tissue scarring. In this study, we used a stab wound injury model in zebrafish and identified an injury-induced microglial state characterized b
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 265-271 (2010)
Methylene blue is an FDA approved compound with a variety of pharmacologic activities. It inhibits aggregation of several amyloidogenic proteins known to be deposited in neurodegenerative diseases. Recently, it has been proposed that methylene blue s
Externí odkaz:
https://doaj.org/article/58c22d3fa5134bc0ac235044784489c3
Autor:
Mareike E Fett, Anna Pilsl, Dominik Paquet, Frauke van Bebber, Christian Haass, Jörg Tatzelt, Bettina Schmid, Konstanze F Winklhofer
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11783 (2010)
Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantia
Externí odkaz:
https://doaj.org/article/88d7d03040ee4968a2ef81a834585572
Autor:
Daniel Fleck, Frauke van Bebber, Stefan F. Lichtenthaler, Benjamin M. Schwenk, Christian Haass, Bettina Schmid, Dieter Edbauer, Chiara Galante, Bozidar Novak, Linnéa Rabe, Elisabeth Kremmer, Michael Willem, Heike Hampel, Sabina Tahirovic, Alessio Colombo
Publikováno v:
The journal of neuroscience 33(18), 7856-7869 (2013). doi:10.1523/JNEUROSCI.3372-12.2013
J. Neurosci. 33, 7856-7869 (2013)
J. Neurosci. 33, 7856-7869 (2013)
Proteolytic shedding of cell surface proteins generates paracrine signals involved in numerous signaling pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which it requires proteolytic activation
Autor:
Anne-Kathrin Garz, Ulrich Germing, Frauke van Bebber, Martina Rudelius, Katharina Götze, Ruth Eichner, Anna-Maria Knorn, Vanesa Fernández-Sáiz, Bettina Schmid, Christian Haass, H. Einsele, Bernhard Kuster, Christian Peschel, Florian Bassermann, Stefan Knop, Jolanta Slawska, Simone Lemeer, Christian Langer, Bianca-Sabrina Targosz, Ulrich Keller, Laura Jacobs, Uwe Platzbecker, Michael Heider
Publikováno v:
Nature Medicine, 22(7), 735. Nature Publishing Group
Nature medicine 22(7), 735-743 (2016). doi:10.1038/nm.4128
Nature medicine 22(7), 735-743 (2016). doi:10.1038/nm.4128
Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517bd673db89b497ffcf5aa22ade20b5
https://dspace.library.uu.nl/handle/1874/344119
https://dspace.library.uu.nl/handle/1874/344119
Autor:
Frauke van Bebber, Vincenzo Capece, Eva Benito, Magali Hennion, Ramon O. Vidal, Sanaz Bahari Javan, Orr Shomroni, Stefan Bonn, Christian Haass, Susanne Burkhardt, Ashish Rajput, Tonatiuh Pena Centeno, Rashi Halder, Julio C. Garcia Vizcaino, Andre Fischer, Magdalena Navarro Sala, Raza-Ur Rahman, Anna-Lena Schuetz, Bettina Schmid
Publikováno v:
Nature reviews / Neuroscience 19(1), 102-110 (2016). doi:10.1038/nn.4194
The ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e9af6097307419096d12871ff24691
https://pub.dzne.de/record/138297
https://pub.dzne.de/record/138297
Publikováno v:
Neurobiology of Disease; Vol 39
Neurobiology of disease 39(3), 265-271 (2010). doi:10.1016/j.nbd.2010.03.023
Neurobiology of Disease, Vol 39, Iss 3, Pp 265-271 (2010)
Neurobiology of disease 39(3), 265-271 (2010). doi:10.1016/j.nbd.2010.03.023
Neurobiology of Disease, Vol 39, Iss 3, Pp 265-271 (2010)
Methylene blue is an FDA approved compound with a variety of pharmacologic activities. It inhibits aggregation of several amyloidogenic proteins known to be deposited in neurodegenerative diseases. Recently, it has been proposed that methylene blue s
Autor:
Kerri S. Warren, Donald Jackson, Jau-Nian Chen, Allan M. Goldstein, Per Lindahl, George N. Serbedzija, Mark C. Fishman, Frauke van Bebber, John D. Mably, Fabrizio C. Serluca, Alan N. Mayer, Pascal Haffter, Sarah J. Childs
Publikováno v:
Comparative and Functional Genomics
Comparative and functional genomics, vol 2, iss 2
Comparative and Functional Genomics, Vol 2, Iss 2, Pp 60-68 (2001)
Comparative and functional genomics, vol 2, iss 2
Comparative and Functional Genomics, Vol 2, Iss 2, Pp 60-68 (2001)
All internal organs are asymmetric along the left–right axis. Here we report a genetic screen to discover mutations which perturb organ laterality. Our particular focus is upon whether, and how, organs are linked to each other as they achieve their