Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Frauke Stanke"'
Autor:
Esther Schamschula, Angelika Lahnsteiner, Yassen Assenov, Wolfgang Hagmann, Nadja Zaborsky, Markus Wiederstein, Anna Strobl, Frauke Stanke, Thomas Muley, Christoph Plass, Burkhard Tümmler, Angela Risch
Publikováno v:
Epigenetics, Vol 17, Iss 8, Pp 837-860 (2022)
Cystic fibrosis (CF) is a monogenic disease, characterized by massive chronic lung inflammation. The observed variability in clinical phenotypes in monozygotic CF twins is likely associated with the extent of inflammation. This study sought to invest
Externí odkaz:
https://doaj.org/article/c7a930fa9d8f4925abc3c509791603ca
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/56597c34da714e258633e573dfe3cf12
Autor:
Frauke Stanke, Sophia T. Pallenberg, Stephanie Tamm, Silke Hedtfeld, Ella M. Eichhorn, Rebecca Minso, Gesine Hansen, Tobias Welte, Annette Sauer-Heilborn, Felix C. Ringshausen, Sibylle Junge, Burkhard Tümmler, Anna-Maria Dittrich
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Defects in expression, maturation or function of the epithelial membrane glycoprotein CFTR are causative for the progressive disease cystic fibrosis. Recently, molecular therapeutics that improve CFTR maturation and functional defects hav
Externí odkaz:
https://doaj.org/article/7cc5bf37360f4ab5bcfbf6cd9a5992a0
Autor:
Mark-Christian Jaboreck, Jonathan Lukas Lühmann, Mia Mielenz, Frauke Stanke, Gudrun Göhring, Ulrich Martin, Ruth Olmer, Sylvia Merkert
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102918- (2022)
The Transmembrane member 16A (TMEM16A), also known as anoctamin-1 (ANO1), is a calcium-activated chloride channel present in the airway epithelium. It is known to be involved in the apical chloride secretion indicating that TMEM16A could be addressed
Externí odkaz:
https://doaj.org/article/5b485fa104404f5ba6bd8e07af661d5f
Autor:
Tim Becker, Andreas Pich, Stephanie Tamm, Silke Hedtfeld, Mohammed Ibrahim, Janine Altmüller, Nina Dalibor, Mohammad Reza Toliat, Sabina Janciauskiene, Burkhard Tümmler, Frauke Stanke
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract SCNN1B encodes the beta subunit of the epithelial sodium channel ENaC. Previously, we reported an association between SNP markers of SCNN1B gene and disease severity in cystic fibrosis-affected sibling pairs. We hypothesized that factors int
Externí odkaz:
https://doaj.org/article/dcc752896878496ebfa52dadd5b3f362
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Cystic fibrosis (CF) is a genetic disease caused by mutations in CFTR, which encodes a chloride and bicarbonate transporter expressed in exocrine epithelia throughout the body. Recently, some therapeutics became available that directly ta
Externí odkaz:
https://doaj.org/article/f67d58b79e284a1a984add6c35680dc3
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1278 (2022)
An adequate visualization form is required to gain an overview and ultimately understand the complex and diverse biological mechanisms of diseases. Recently, disease maps have been introduced for this purpose. A disease map is defined as a systems bi
Externí odkaz:
https://doaj.org/article/462f6fa0be8546188e6e98a2d0ee525e
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sixteen monozygotic cystic fibrosis (CF) twin pairs of whom 14 pairs were homozygous for the most common p.Phe508del CFTR mutation were selected from the European Cystic Fibrosis Twin and Sibling Study Cohort. The monozygotic twins were examined in t
Externí odkaz:
https://doaj.org/article/3d3094d203b14792ab9155d0f2a46f5e
Autor:
Tobias Welte, Rebecca Minso, Angela Schulz, Christian Dopfer, Nadine Alfeis, Andrea van Barneveld, Lena Makartian-Gyulumyan, Gesine Hansen, Sibylle Junge, Carsten Müller, Felix C C Ringshausen, Annette Sauer-Heilborn, Frauke Stanke, Cornelia Stolpe, Stephanie Tamm, Anna-Maria Dittrich, Burkhard Tümmler
Publikováno v:
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
Background Nasal potential difference (NPD) and intestinal current measurements (ICM) are cystic fibrosis transmembrane conductance regulator (CFTR) biomarkers recommended to make a diagnosis in individuals with inconclusive sweat test and CFTR genet
Externí odkaz:
https://doaj.org/article/064282ba84d44b75846a572f39987840
Autor:
Frauke Stanke, Sabina Janciauskiene, Stephanie Tamm, Sabine Wrenger, Ellen Luise Raddatz, Danny Jonigk, Peter Braubach
Publikováno v:
Molecules, Vol 26, Iss 9, p 2639 (2021)
The cystic fibrosis transmembrane conductance regulator (CFTR) gene is influenced by the fundamental cellular processes like epithelial differentiation/polarization, regeneration and epithelial–mesenchymal transition. Defects in CFTR protein levels
Externí odkaz:
https://doaj.org/article/343e8c6ff833496d8d9ecec15acc0170