Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Frauke Nitzki"'
Autor:
Joanna Pyczek, Natalia Khizanishvili, Maria Kuzyakova, Sebastian Zabel, Julia Bauer, Frauke Nitzki, Steffen Emmert, Michael P. Schön, Petra Boukamp, Hans-Ulrich Schildhaus, Anja Uhmann, Heidi Hahn
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor in humans. Although current therapies are sufficient to clear the tumor in many cases, the overall risk of cSCC metastasis is still 5%. Alternative treatment options could
Externí odkaz:
https://doaj.org/article/d3b9a30dc5574fc9a86bae19b6af5147
Autor:
Simone König, Frauke Nitzki, Anja Uhmann, Kai Dittmann, Jennifer Theiss-Suennemann, Markus Herrmann, Holger M Reichardt, Reto Schwendener, Tobias Pukrop, Walter Schulz-Schaeffer, Heidi Hahn
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93555 (2014)
Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse m
Externí odkaz:
https://doaj.org/article/e330aa80843a4dd0bbf5f0d15e43be40
Autor:
Diana Marklein, Ulrike Graab, Ivonne Naumann, Tiandong Yan, Rosalie Ridzewski, Frauke Nitzki, Albert Rosenberger, Kai Dittmann, Jürgen Wienands, Leszek Wojnowski, Simone Fulda, Heidi Hahn
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52898 (2012)
We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis.
Externí odkaz:
https://doaj.org/article/020fc499aaa144d3854f585b67f7895b
Publikováno v:
Journal of Skin Cancer, Vol 2012 (2012)
Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care syste
Externí odkaz:
https://doaj.org/article/8487b2bf570345a997329d2cfaa258cc
Autor:
Heidi Hahn, Olaf Witt, Walter Schulz-Schaeffer, Leszek Wojnowski, Frauke Nitzki, Anja Uhmann, Steven A. Johnsen, Judith Pirngruber, Sarah Kimmina, Christian Dullin, Ina Hess, Sven Mönkemeyer, Svantje Tauber, Albert Rosenberger, Frauke Petry, Ines Ecke
Supplementary Table 1 from Antitumor Effects of a Combined 5-Aza-2′Deoxycytidine and Valproic Acid Treatment on Rhabdomyosarcoma and Medulloblastoma in Ptch Mutant Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f1d0caf89683250cd0a8a0c6af3fce
https://doi.org/10.1158/0008-5472.22380788.v1
https://doi.org/10.1158/0008-5472.22380788.v1
Autor:
Heidi Hahn, Walter Schulz-Schaeffer, Fritz Aberger, Tobias Pukrop, Julia Reifenberger, Stefan Klingler, Anja Uhmann, Anke Frommhold, Per-Ole Carstens, Felix H. Brembeck, Albert Rosenberger, Mark Wijgerde, Simone König, Arne Zibat, Frauke Nitzki
Supplementary Methods, Tables 1-2 and Figures from Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of Ptch-Mutant Mice via CaMKII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0683584dd86c9cbcdbb7a9fb1bb38472
https://doi.org/10.1158/0008-5472.22387313.v1
https://doi.org/10.1158/0008-5472.22387313.v1
Autor:
Heidi Hahn, Olaf Witt, Walter Schulz-Schaeffer, Leszek Wojnowski, Frauke Nitzki, Anja Uhmann, Steven A. Johnsen, Judith Pirngruber, Sarah Kimmina, Christian Dullin, Ina Hess, Sven Mönkemeyer, Svantje Tauber, Albert Rosenberger, Frauke Petry, Ines Ecke
Patched (Ptch) heterozygous mice develop medulloblastoma (MB) and rhabdomyosarcoma (RMS) resembling the corresponding human tumors. We have previously shown that epigenetic silencing of the intact Ptch allele contributes to tumor formation in this mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87399f4225770ce74bf9daf8be16a622
https://doi.org/10.1158/0008-5472.c.6499676.v1
https://doi.org/10.1158/0008-5472.c.6499676.v1
Autor:
Natalie Geyer, Hans-Ulrich Schildhaus, Albert Rosenberger, Stefano Biressi, Dieter Saur, James A. Fagin, Katja Simon-Keller, Frauke Nitzki, Dominik Simon Botermann, Christian Dullin, Heidi Hahn, Nada Ragab, Dominik P. Elmer, Julia Bauer, Nicole Cuvelier, Thomas A. Rando, Walter J. Schulz-Schaeffer, Anja Uhmann, Fritz Aberger
Publikováno v:
Oncogene
A prototypic pediatric cancer that frequently shows activation of RAS signaling is embryonal rhabdomyosarcoma (ERMS). ERMS also show aberrant Hedgehog (HH)/GLI signaling activity and can be driven by germline mutations in this pathway. We show, that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27af6063d14bdc3871d3537be149c55c
https://pubmed.ncbi.nlm.nih.gov/34172934
https://pubmed.ncbi.nlm.nih.gov/34172934
Autor:
Joanna, Pyczek, Natalia, Khizanishvili, Maria, Kuzyakova, Sebastian, Zabel, Julia, Bauer, Frauke, Nitzki, Steffen, Emmert, Michael P, Schön, Petra, Boukamp, Hans-Ulrich, Schildhaus, Anja, Uhmann, Heidi, Hahn
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics
Frontiers in Genetics
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor in humans. Although current therapies are sufficient to clear the tumor in many cases, the overall risk of cSCC metastasis is still 5%. Alternative treatment options could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2448b1e2a751a57bb17dd6a2f1fb8279
http://resolver.sub.uni-goettingen.de/purl?gs-1/16829
http://resolver.sub.uni-goettingen.de/purl?gs-1/16829
Publikováno v:
Oncogene. 35:2923-2931
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. In children, the 2 major RMS subtypes are alveolar and embryonal RMS. Aberrant Hedgehog/Patched1 (Hh/Ptch) signaling is a hallmark of embryonal RMS. We demonstrate that mice car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcda5b2984673987fd2f5c2580dc413
https://doi.org/10.1038/onc.2015.346
https://doi.org/10.1038/onc.2015.346