Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Frauke Melchior"'
Autor:
Juan F. Correa-Vázquez, Francisco Juárez-Vicente, Pablo García-Gutiérrez, Sina V. Barysch, Frauke Melchior, Mario García-Domínguez
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Post-translational modification by covalent attachment of the Small ubiquitin-like modifier (Sumo) polypeptide regulates a multitude of processes in vertebrates. Despite demonstrated roles of Sumo in the development and function of the nervo
Externí odkaz:
https://doaj.org/article/fb342dbda1cb479cb2cd28e333a5186d
Autor:
Annette Aichem, Carolin Sailer, Stella Ryu, Nicola Catone, Nicolas Stankovic-Valentin, Gunter Schmidtke, Frauke Melchior, Florian Stengel, Marcus Groettrup
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
FAT10 is an ubiquitin-like modifier that targets proteins to proteasomal degradation. Here, the authors show that FAT10 also regulates SUMO activation in vitro and in cells, providing evidence for functional crosstalk between two ubiquitin-like modif
Externí odkaz:
https://doaj.org/article/c189585808444a29aa898a977aa4e6e8
Autor:
M Görkem Patir Nebioglu, Zaida Andrés, Melanie Krebs, Fabian Fink, Katarzyna Drzewicka, Nicolas Stankovic-Valentin, Shoji Segami, Sebastian Schuck, Michael Büttner, Rüdiger Hell, Masayoshi Maeshima, Frauke Melchior, Karin Schumacher
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/2c483d9c7b8842449cd4f1710b697d44
Autor:
Tobias Ritterhoff, Hrishikesh Das, Götz Hofhaus, Rasmus R. Schröder, Annette Flotho, Frauke Melchior
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Continuous cycles of nucleo-cytoplasmic transport require disassembly of transport receptor-Ran-GTP complexes in the cytoplasm. Here the authors elucidate the specific function of the RanBP2 complex in the disassembly process.
Externí odkaz:
https://doaj.org/article/1f54f589719b4570b7ab83fd1cc8a098
Autor:
Hao Zhou, Katarzyna Bulek, Xiao Li, Tomasz Herjan, Minjia Yu, Wen Qian, Han Wang, Gao Zhou, Xing Chen, Hui Yang, Lingzi Hong, Junjie Zhao, Luke Qin, Koichi Fukuda, Annette Flotho, Ji Gao, Ashok Dongre, Julie A Carman, Zizhen Kang, Bing Su, Timothy S Kern, Jonathan D Smith, Thomas A Hamilton, Frauke Melchior, Paul L Fox, Xiaoxia Li
Publikováno v:
eLife, Vol 6 (2017)
Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 e
Externí odkaz:
https://doaj.org/article/5b84f1b2b69f41da8fc9474e0ca9c10d
Autor:
Marc Vorpahl, Sabine Schönhofer-Merl, Cornelia Michaelis, Annette Flotho, Frauke Melchior, Rainer Wessely
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101519 (2014)
Differentiation and dedifferentiation, accompanied by proliferation play a pivotal role for the phenotypic development of vascular proliferative diseases (VPD), such as restenosis. Increasing evidence points to an essential role of regulated nucleopo
Externí odkaz:
https://doaj.org/article/38bfdab6254a4fcc9148f58d8488057d
Autor:
Daniël Splinter, Marvin E Tanenbaum, Arne Lindqvist, Dick Jaarsma, Annette Flotho, Ka Lou Yu, Ilya Grigoriev, Dieuwke Engelsma, Elize D Haasdijk, Nanda Keijzer, Jeroen Demmers, Maarten Fornerod, Frauke Melchior, Casper C Hoogenraad, René H Medema, Anna Akhmanova
Publikováno v:
PLoS Biology, Vol 8, Iss 4, p e1000350 (2010)
BICD2 is one of the two mammalian homologues of the Drosophila Bicaudal D, an evolutionarily conserved adaptor between microtubule motors and their cargo that was previously shown to link vesicles and mRNP complexes to the dynein motor. Here, we iden
Externí odkaz:
https://doaj.org/article/10400eedc65345748f1c28fcffc7b328
Autor:
Ana Jimena Alfaro Nunez, Claudia Dittner, Janina Becker, Anne Loft, Amit Mhamane, Adriano Maida, Anastasia Georgiadi, Phivos Tsokanos, Katarina Klepac, Eveline Molocea, Rabih Merahbi, Karsten Motzler, Julia Geppert, Rhoda Anane Karikari, Julia Szendrödi, Annette Feuchtinger, Susanna Hofmann, Frauke Melchior, Stephan Herzig
The liver is the major metabolic hub, ensuring appropriate nutrient supply during fasting and feeding. In obesity, accumulation of excess nutrients hampers proper liver function and is linked to non-alcoholic fatty liver disease. Understanding the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4307bd65cd9049ebf78470aaf32f555
https://doi.org/10.1101/2022.08.17.504229
https://doi.org/10.1101/2022.08.17.504229
Autor:
Nicola Catone, Frauke Melchior, Florian Stengel, Marcus Groettrup, Annette Aichem, Gunter Schmidtke, Nicolas Stankovic-Valentin, Stella Ryu, Carolin Sailer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
The covalent attachment of the cytokine-inducible ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) to hundreds of substrate proteins leads to their rapid degradation by the 26 S proteasome independently of ubiquitylation. Here, we identif
Autor:
Klaus Meese, Felix Mikus, Roman Beloshistov, Gregor Habeck, Shoji Hata, Frauke Melchior, Sandra Hess, Jörg Schweiggert, Klaus-Peter Knobeloch
Publikováno v:
The EMBO Journal. 40
Microtubule depolymerases of the kinesin-13 family play important roles in various cellular processes and are frequently overexpressed in different cancer types. Despite the importance of their correct abundance, remarkably little is known about how