Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Frauke May"'
Autor:
Dipti Pawaskar, Xi Chen, Fiona Glassman, Frauke May, Anthony Roberts, Mark Biondo, Andrew McKenzie, Marc W. Nolte, William J. Jusko, Michael Tortorici
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 3, Pp 709-720 (2022)
Abstract Factor XII (FXII) is a serine protease involved in multiple cascades, including the kallikrein–kinin system. It may play a role in diseases in which the downstream cascades are dysregulated, such as hereditary angioedema. Garadacimab (CSL3
Externí odkaz:
https://doaj.org/article/f33f67a9542a4828bd212a5451562254
Autor:
Nadine J.A. Mattheij, Frauke Swieringa, Tom G. Mastenbroek, Michelle A. Berny-Lang, Frauke May, Constance C.F.M.J. Baaten, Paola E.J. van der Meijden, Yvonne M.C. Henskens, Erik A.M. Beckers, Dennis P.L. Suylen, Marc W. Nolte, Tilman M. Hackeng, Owen J.T. McCarty, Johan W.M. Heemskerk, Judith M.E.M. Cosemans
Publikováno v:
Haematologica, Vol 101, Iss 4 (2016)
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen bin
Externí odkaz:
https://doaj.org/article/a3218945d5764b0d8ab4b3ee2b832f09
Autor:
Jennifer Krupka, Frauke May, Thomas Weimer, Ingo Pragst, Christoph Kleinschnitz, Guido Stoll, Con Panousis, Gerhard Dickneite, Marc W Nolte
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146783 (2016)
BACKGROUND AND PURPOSE:Ischemic stroke provokes severe brain damage and remains a predominant disease in industrialized countries. The coagulation factor XII (FXII)-driven contact activation system plays a central, but not yet fully defined pathogeni
Externí odkaz:
https://doaj.org/article/9836f5b3bbb9458a890a7684b9626651
Autor:
David Stegner, Vanessa Göb, Viola Krenzlin, Sarah Beck, Katherina Hemmen, Michael K. Schuhmann, Barbara F. Schörg, Christian Hackenbroch, Frauke May, Philipp Burkard, Jürgen Pinnecker, Alma Zernecke, Peter Rosenberger, Andreas Greinacher, Bernd J. Pichler, Katrin G. Heinze, Guido Stoll, Bernhard Nieswandt
Publikováno v:
Nature Cardiovascular Research. 1:132-141
Cerebral venous (sinus) thrombosis (CVT) is an unusual manifestation of venous thrombosis causing severe neurological impairment and seizures1,2. Molecular mechanisms underlying CVT, potentially involving pathological platelet activation, are unknown
Autor:
Xi Chen, Dipti Pawaskar, Fiona Glassman, Mark Biondo, Frauke May, Anthony Roberts, Andrew McKenzie, Michael A. Tortorici, Marc W. Nolte, William J. Jusko
Publikováno v:
Clinical and Translational Science. 15:709-720
Factor XII (FXII) is a serine protease involved in multiple cascades, including the kallikrein-kinin system. It may play a role in diseases in which the downstream cascades are dysregulated, such as hereditary angioedema. Garadacimab (CSL312) is a fi
Autor:
Eva Eilers, Vanessa Göb, Con Panousis, Stefan Loroch, Frauke May, Cornelia Schumbrutzki, Bernhard Nieswandt, Ayesha A Baig, Marc W. Nolte, Sarah Beck, Albert Sickmann, David Stegner
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2835-2840
Background Effective inhibition of thrombosis without generating bleeding risks is a major challenge in medicine. Accumulating evidence suggests that this can be achieved by inhibition of coagulation factor XII (FXII), as either its knock-out or inhi
Autor:
Sabrina Herrmann, Benjamin Kuehnemuth, Gerhard Dickneite, Frauke May, Eva Herzog, Baerbel Doerr, Deya Cherpokova, Marc W. Nolte
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 18(12)
Background Hemophilia B is caused by coagulation factor IX (FIX) deficiency. Recombinant fusion protein linking coagulation FIX with recombinant albumin (rIX-FP; Idelvion® ) is used for replacement therapy with an extended half-life. A previous quan
Autor:
Michelle A. Berny-Lang, Paola E. J. van der Meijden, Judith M.E.M. Cosemans, Johan W. M. Heemskerk, Constance C.F.M.J. Baaten, Yvonne M. C. Henskens, Tilman M. Hackeng, Frauke May, Owen J. T. McCarty, Marc W. Nolte, Dennis Suylen, Frauke Swieringa, Tom G. Mastenbroek, Nadine J.A. Mattheij, Erik A M Beckers
Publikováno v:
Haematologica-the Hematology Journal, 101(4), 427-436. Ferrata Storti Foundation
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of alpha-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen
Autor:
Andrew J. Morris, Lijun Xia, Bernhard Nieswandt, Florea Lupu, Robert Silasi-Mansat, Hong Chen, Minjia Sheng, Paul R. Hess, J. Michael McDaniel, Tadayuki Yago, Frauke May, Mark L. Kahn, Yanfang Pan, Stephen J. Wilson, Aslihan Sen, Brett H. Herzog, Shaun R. Coughlin, Jianxin Fu, Samuel McGee, Rodger P. McEver
Publikováno v:
Nature
Circulating lymphocytes continuously enter lymph nodes for immune surveillance through specialized blood vessels named high endothelial venules, a process that increases markedly during immune responses. How high endothelial venules (HEVs) permit lym
Autor:
Frauke May, Ina Hagedorn, Timo Vögtle, Brenda A. Finney, Michael R. Bösl, Steve P. Watson, Markus Bender, Katharina A. Remer, Attila Braun, Viola Lorenz, Ina Thielmann, Bernhard Nieswandt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:926-934
Objective— Platelet inhibition is a major strategy to prevent acute ischemic cardiovascular and cerebrovascular events, which may, however, be associated with an increased bleeding risk. The (hem)immunoreceptor tyrosine activation motif–bearing p