Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Frauke Gräter"'
Autor:
Florian Franz, Rafael Tapia-Rojo, Sabina Winograd-Katz, Rajaa Boujemaa-Paterski, Wenhong Li, Tamar Unger, Shira Albeck, Camilo Aponte-Santamaria, Sergi Garcia-Manyes, Ohad Medalia, Benjamin Geiger, Frauke Gräter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single-molecule magnetic tweezers experiments, Molecular D
Externí odkaz:
https://doaj.org/article/30b01a749e4c45a4a0ec2338d1b1bd92
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 12, p e1011726 (2023)
Plasmodium falciparum (Pf) is responsible for the most lethal form of malaria. VAR2CSA is an adhesin protein expressed by this parasite at the membrane of infected erythrocytes for attachment to the placenta, leading to pregnancy-associated malaria.
Externí odkaz:
https://doaj.org/article/b90f84eb43884eb09ab483656cb687e8
Autor:
Benedikt Rennekamp, Christoph Karfusehr, Markus Kurth, Aysecan Ünal, Debora Monego, Kai Riedmiller, Ganna Gryn’ova, David M. Hudson, Frauke Gräter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The
Externí odkaz:
https://doaj.org/article/93bad5531e0c4d02b768e6b54931006e
Autor:
Svenja de Buhr, Frauke Gräter
Publikováno v:
eLife, Vol 12 (2023)
c-Abl kinase, a key signaling hub in many biological processes ranging from cell development to proliferation, is tightly regulated by two inhibitory Src homology domains. An N-terminal myristoyl modification can bind to a hydrophobic pocket in the k
Externí odkaz:
https://doaj.org/article/9d6b0bf0a3ba4d0694a4e4d604d1cbcb
Autor:
Niccolò Banterle, Adrian P. Nievergelt, Svenja de Buhr, Georgios N. Hatzopoulos, Charlène Brillard, Santiago Andany, Tania Hübscher, Frieda A. Sorgenfrei, Ulrich S. Schwarz, Frauke Gräter, Georg E. Fantner, Pierre Gönczy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The centriole exhibits an evolutionarily conserved 9-fold radial symmetry that stems from a cartwheel containing vertically stacked ring polymers that harbor 9 homodimers of the protein SAS-6. Here the authors show how dual properties inherent to sur
Externí odkaz:
https://doaj.org/article/62dd094a411e49c59faaf20446460035
Autor:
Christopher Zapp, Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Markus Kurth, David M. Hudson, Davide Mercadante, Uladzimir Barayeu, Tobias P. Dick, Vasyl Denysenkov, Thomas Prisner, Marina Bennati, Csaba Daday, Reinhard Kappl, Frauke Gräter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radica
Externí odkaz:
https://doaj.org/article/50b8db94c94742b2bea4990163c8a11d
Autor:
Fan Jin, Frauke Gräter
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008939 (2021)
Phosphorylation of intrinsically disordered proteins (IDPs) can produce changes in structural and dynamical properties and thereby mediate critical biological functions. How phosphorylation effects intrinsically disordered proteins has been studied f
Externí odkaz:
https://doaj.org/article/fbfd7ad1a1084ce993d2c73188725c54
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Microtubules are one of the most important components in the cytoskeleton and play a vital role in maintaining the shape and function of cells. Because single microtubules are some micrometers long, it is difficult to simulate such a large system usi
Externí odkaz:
https://doaj.org/article/0ed7a38003624a3a86dbdb475b412548
Autor:
Piau Siong Tan, Iker Valle Aramburu, Davide Mercadante, Swati Tyagi, Aritra Chowdhury, Daniel Spitz, Sarah L. Shammas, Frauke Gräter, Edward A. Lemke
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3660-3671 (2018)
Summary: Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to inte
Externí odkaz:
https://doaj.org/article/380e982b92924a18a55fbbab5cd803e3
Autor:
Gustavo Caetano-Anollés, M Fayez Aziz, Fizza Mughal, Frauke Gräter, Ibrahim Koç, Kelsey Caetano-Anollés, Derek Caetano-Anollés
Publikováno v:
Evolutionary Bioinformatics, Vol 15 (2019)
Networks describe how parts associate with each other to form integrated systems which often have modular and hierarchical structure. In biology, network growth involves two processes, one that unifies and the other that diversifies. Here, we propose
Externí odkaz:
https://doaj.org/article/d7fb2d3441494a748df4f0c994e43007