Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Frauke Assmus"'
1
Akademický článek
Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside
Autor: Frauke Assmus, Richard M. Hoglund, Frédéric Monnot, Sabine Specht, Ivan Scandale, Joel Tarning
Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 3 (2022)
Background To accelerate the progress towards onchocerciasis elimination, a macrofilaricidal drug that kills the adult parasite is urgently needed. Emodepside has shown macrofilaricidal activity against a variety of nematodes and is currently under c
Externí odkaz: https://doaj.org/article/c7a5f129570342808d05e3631babd9f3
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2
Akademický článek
Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19
Autor: Frauke Assmus, Jean-Sélim Driouich, Rana Abdelnabi, Laura Vangeel, Franck Touret, Ayorinde Adehin, Palang Chotsiri, Maxime Cochin, Caroline S. Foo, Dirk Jochmans, Seungtaek Kim, Léa Luciani, Grégory Moureau, Soonju Park, Paul-Rémi Pétit, David Shum, Thanaporn Wattanakul, Birgit Weynand, Laurent Fraisse, Jean-Robert Ioset, Charles E. Mowbray, Andrew Owen, Richard M. Hoglund, Joel Tarning, Xavier de Lamballerie, Antoine Nougairède, Johan Neyts, Peter Sjö, Fanny Escudié, Ivan Scandale, Eric Chatelain
Publikováno v: Microorganisms, Vol 10, Iss 8, p 1639 (2022)
In the absence of drugs to treat or prevent COVID-19, drug repurposing can be a valuable strategy. Despite a substantial number of clinical trials, drug repurposing did not deliver on its promise. While success was observed with some repurposed drugs
Externí odkaz: https://doaj.org/article/a9ef2617e75845fa98746d7ddae47ef7
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4
Carbohydrate-dense snacks are a key feature of the nutrition transition among Ghanaian adults - findings from the RODAM study
Autor: Erik Beune, Mary Nicolaou, Matthias B. Schulze, Charles Agyemang, Karien Stronks, Sven Knueppel, Silver Bahendeka, Joachim Spranger, Cecilia Galbete, Ina Danquah, Karlijn Meeks, Frank P. Mockenhaupt, Stephen K. Amoah, Frauke Assmus, Liam Smeeth, Kerstin Klipstein-Grobusch
Publikováno v: Food & nutrition research, 65:5435
Food and Nutrition Research, 65:5435
Food & Nutrition Research
Background: African populations in sub-Saharan Africa and African migrants in Europe are facing a rapid upsurge in obesity. This trend has been related to urbanization, migration and associated shifts in lifestyle, including dietary habits. Whether c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee4aaefb01d69828417ffce61427368
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5
Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs
Autor: Frauke Assmus, Aleksandra Galetin, J. Brian Houston
Publikováno v: Assmus, F, Houston, J & Galetin, A 2017, ' Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2017.08.014
The prediction of tissue-to-plasma water partition coefficients (Kpu) from in vitro and in silico data using the tissue-composition based model (Rodgers & Rowland, J Pharm Sci. 2005, 94(6):1237–48.) is well established. However, distribution of bas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8f5f5f03d93b16166b74833d75d4a8
https://doi.org/10.1016/j.ejps.2017.08.014
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6
31P and 1H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay
Autor: Joachim Seelig, Holger Fischer, Frauke Assmus, Anna Seelig, Alfred Ross
Publikováno v: Molecular Pharmaceutics. 14:284-295
The parallel artificial membrane permeability assay (PAMPA) has emerged as a widely used primary in vitro screen for passive permeability of potential drug candidates. However, the molecular structure of the permeation barrier (consisting of a filter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fae0f042b6d26f586ae6717560cb82e
https://doi.org/10.1021/acs.molpharmaceut.6b00889
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7
Estimation of Drug Binding to Brain Tissue: Methodology and in Vivo Application of a Distribution Assay in Brain Polar Lipids
Autor: Sara Belli, Rubén Alvarez-Sánchez, Holger Fischer, Frauke Assmus, Franz Schuler, Bjoern Wagner, Michael Honer
Publikováno v: Molecular Pharmaceutics. 12:4529-4541
The unbound drug concentration-effect relationship in brain is a key aspect in CNS drug discovery and development. In this work, we describe an in vitro high-throughput distribution assay between an aqueous buffer and a microemulsion of porcine brain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6340d05f79540179f78b60ded279b01b
https://doi.org/10.1021/acs.molpharmaceut.5b00717
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8
In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages
Autor: Ayşe, Ufuk, Frauke, Assmus, Laura, Francis, Jonathan, Plumb, Valeriu, Damian, Michael, Gertz, J Brian, Houston, Aleksandra, Galetin
Publikováno v: Molecular pharmaceutics. 14(4)
Accumulation of respiratory drugs in human alveolar macrophages (AMs) has not been extensively studied in vitro and in silico despite its potential impact on therapeutic efficacy and/or occurrence of phospholipidosis. The current study aims to charac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2e885c35cf62f600441d2c1caa64c97
https://pubmed.ncbi.nlm.nih.gov/28252969
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9
Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates
Autor: Holger Fischer, Anna Seelig, Edilio Borroni, Patricia Glaentzlin, Luca Gobbi, Frauke Assmus
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 79
Positron emission tomography (PET) is a valuable non-invasive technique for the visualization of drug tissue distribution and receptor occupancy at the target site in living animals and men. Many potential PET tracers, however, fail due to an unfavor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe19af67278c4bc544cef6c4c7e09934
https://pubmed.ncbi.nlm.nih.gov/26341407
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10
Carrier Mediated Distribution System (CAMDIS): a new approach for the measurement of octanol/water distribution coefficients
Autor: Anna Seelig, Frauke Assmus, Bjoern Wagner, Holger Fischer, Manfred Kansy
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 68
Here we present a miniaturized assay, referred to as Carrier-Mediated Distribution System (CAMDIS) for fast and reliable measurement of octanol/water distribution coefficients, log D(oct). By introducing a filter support for octanol, phase separation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2557589e6834add53a1e61f6f87ef9e9
https://pubmed.ncbi.nlm.nih.gov/25513709
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